1974
DOI: 10.1210/jcem-38-3-390
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Thyroxine (T4) and Triiodothyronine (T3): Effects of Iodine on the Serum Concentrations and Disposal Rates in Subjects from an Endemic Goiter Area

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Cited by 26 publications
(13 citation statements)
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“…Other factors that might modify the serum T 3 concentration have not been carefully studied. Thus, the MCR of T 3 in goitrous subjects has been reported to be increased (24) or unchanged (23). Peripheral deiodination of T 4 to T 3 has not been investigated in goitrous subjects.…”
Section: Discussionmentioning
confidence: 99%
“…Other factors that might modify the serum T 3 concentration have not been carefully studied. Thus, the MCR of T 3 in goitrous subjects has been reported to be increased (24) or unchanged (23). Peripheral deiodination of T 4 to T 3 has not been investigated in goitrous subjects.…”
Section: Discussionmentioning
confidence: 99%
“…The common effect of iodine deficiency in adults is endemic goitre and the typical patient is not clinically hypothyroid, but many have a low serum thyroxine. This is often accompanied by a normal or elevated T3 concentration and a raised TSH (Stevenson et al, 1974;Medeiros-Neto et al, 1975;Chopra et al, 1975;Hershman et al, 1983) and normal or exaggerated TSH response to TRH (Medeiros-Neto et a /., 1975). A mild increase in the incidence of thyrotoxicosis has been reported after iodized salt correlated significantly (r=0,72, P<O.OOl) with the size and weight of goitre.…”
Section: Discussionmentioning
confidence: 99%
“…In severe iodine deficiency, the thyroid may not be able to compensate the inadequate supply of iodine and the loss of iodide in the urine, so the T4 levels may greatly decrease. Only rarely, in very severe deficiency, do T3 levels also decrease and cause hypothyroidisim (Goslings et al, 1976); in fact, they often increase (Stevenson et al, 1974, Pate1 et al, 1973.…”
Section: Goitre As a Consequence Of Iodine Deficiency And Other Nutrimentioning
confidence: 99%
“…All these consequences of iodine deficiency, except for the large goitres, are reversible after iodine administration (Thilly et al, 1973;Stevenson et al, 1974;Denef et al, 1989).…”
Section: Goitre As a Consequence Of Iodine Deficiency And Other Nutrimentioning
confidence: 99%