Goiter Size and Thyroid Function in an Endemic Goiter Area in Northern Italy *

Roti, Elio; Gardini, E.; d’Amato, L.; Salvi, Mario; Robuschi, G.; Manfredi, A; Dall’Ara, Gianni; Pino, Sam; Guazzi, Annamaria; Gnudi, A

doi:10.1210/jcem-63-3-558

Cited by 29 publications

(9 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results are in agreement with the previous observation that thyroid function is not significantly affected in mild/moderate iodine deficient areas 16,17 . Goiter by clinical examination and ultrasonography was observed in 35% and 34%, respectively, of all subjects.…”

Section: Discussionsupporting

confidence: 94%

Thyroid Hormone Profile in Children with Goiter in an Endemic Goiter Area

Semiz

Şenol²,

Bircan³

et al. 2001

Journal of Pediatric Endocrinology and Metabolism

View full text Add to dashboard Cite

The thyroid hormone profile was investigated in goitrous schoolchildren aged 6-11 years living in Antalya, an area with mild/ moderate iodine deficiency. With few exceptions, the serum levels of T4 and TSH were in the normal range in children with different grades of goiter. Compensatory elevated T3 levels were detected in 24% of the subjects. Thyroid hormones did not differ significantly with respect to the urinary iodine (UI) level. No correlations were found between thyroid volume, UI excretion level and thyroid hormones. It was concluded that thyroid hormones, except compensatory T3 elevation in some subjects, were not affected significantly in a mild/ moderate iodine deficient area.

show abstract

Section: Discussionsupporting

confidence: 94%

Thyroid Hormone Profile in Children with Goiter in an Endemic Goiter Area

Semiz

Şenol²,

Bircan³

et al. 2001

Journal of Pediatric Endocrinology and Metabolism

View full text Add to dashboard Cite

show abstract

“…The Tg secretion rate was correlated to the thyroid weight. This is in accordance with the findings of elevated Tg concentrations in the peripheral blood in these patients and with the correlation between the size of the goiter and the Tg concentration (17)(18)(19)(20).…”

Section: Discussionsupporting

confidence: 92%

“…Serum Tg concentrations are elevated in various thyroid disorders (17)(18)(19)(20). A significant rise in the serum Tg concentra¬ tion follows a fine needle aspiration biopsy of the thyroid gland (21).…”

Section: Discussionmentioning

confidence: 99%

Basal and Thyrotropin-Stimulated Secretion Rates of Thyroglobulin from the Human Thyroid Gland during Surgery

Tegler¹,

Ericsson²,

Gillquist³

et al. 1993

Thyroid

View full text Add to dashboard Cite

The secretion rates of thyroglobulin were measured under basal conditions and after exogenous and endogenous thyrotropin stimulation in 23 patients during surgery. In 11 patients with normal thyroid glands the median secretion rate of thyroglobulin was 0.7 pmol/24 h. Higher secretion rates were observed in 8 patients with nontoxic nodular goiter (median 22 pmol/24 h; p < 0.001) and in 4 patients with thyroid malignancy (median 2.2 pmol/24h; p < 0.05). Within 10 min after administration of highly purified human thyrotropin into the thyroid artery an increase of the secretion rates was observed in the 9 patients studied with normal thyroid glands and 5 patients with nontoxic nodular goiter. TRH administration to 5 patients induced a slight but nonsignificant increase of the secretion rate of thyroglobulin after 20 min. These results show that thyroglobulin is secreted directly into the thyroid venous blood. They also confirm that thyrotropin is an important regulator of the thyroglobulin secretion.

show abstract

“…These reduced TSH levels especially among the elderly are in contrast to increased TSH as a direct effect of iodine de®ciency as observed in severe iodine de®ciency (20). This is presumably due to autonomous functioning thyroid tissue, as this regional difference in serum TSH was only found in subjects with nodular glands, and it is in accordance with data from moderate iodine de®ciency in Italy, where decreasing levels of serum TSH were found with increasing degrees of goitre at a clinical examination (21). A decline in serum TSH with age corresponds to the ®nding of an increased prevalence of overt as well as sub-clinical hyperthyroidism among the elderly in moderate ID.…”

Section: Discussionsupporting

confidence: 86%

Comparative study of thyroid function and types of thyroid dysfunction in two areas in Denmark with slightly different iodine status

Knudsen

Bülow

Jørgensen

et al. 2000

European Journal of Endocrinology

161

122

View full text Add to dashboard Cite

Objective: The pattern of thyroid dysfunction seems to depend on the iodine status of the population. Prevalence of thyroid dysfunction could be a parameter to consider when evaluating iodine de®ciency disorders in a population. Design: Comparative cross-sectional investigation in two regions in Denmark with marginally different iodine excretion. Methods: A random selection of 4649 participants from the Civil Registration System in Denmark in age groups between 18 and 65 years were examined. Thyroid dysfunction was evaluated from blood samples and questionnaires, and compared with results from ultrasonography. Results: Median iodine excretion was 53 mg/l in Aalborg and 68 mg/l in Copenhagen. Previously diagnosed thyroid dysfunction was found with the same prevalence in the regions. Serum TSH was lower in Aalborg than in Copenhagen (P 0.003) and declined with age in Aalborg, but not in Copenhagen. Not previously diagnosed hyperthyroidism was found with the same overall prevalence in the regions, but in age > 40 years hyperthyroidism was more prevalent in Aalborg (1.3 vs 0.5%, P 0.017). Not previously diagnosed hypothyroidism was found more frequently in Aalborg (0.6 vs 0.2%, P 0.03). Hyperthyroidism was more often associated with macronodular thyroid structure at ultrasound in Aalborg and hypothyroidism was more often associated with patchy thyroid structure in Copenhagen. Conclusions: Signi®cant differences in thyroid dysfunction were found between the regions with a minor difference in iodine excretion. The ®ndings are in agreement with a higher prevalence of thyroid autonomy among the elderly in the most iodine-de®cient region.

show abstract

Goiter Size and Thyroid Function in an Endemic Goiter Area in Northern Italy *

Cited by 29 publications

References 26 publications

Thyroid Hormone Profile in Children with Goiter in an Endemic Goiter Area

Thyroid Hormone Profile in Children with Goiter in an Endemic Goiter Area

Basal and Thyrotropin-Stimulated Secretion Rates of Thyroglobulin from the Human Thyroid Gland during Surgery

Comparative study of thyroid function and types of thyroid dysfunction in two areas in Denmark with slightly different iodine status

Contact Info

Product

Resources

About