Thyroid Hormone Profile in Children with Goiter in an Endemic Goiter Area

Semiz, Serap; Şenol, Utku; Bircan, O; Gümüşlü, Saadet; Korgun, DK; Akçurin, Sema; Bircan, İffet

doi:10.1515/jpem.2001.14.2.171

Cited by 3 publications

(2 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This finding corroborates the idea that iodine deficiency is still a significant public health problem in our region. Some studies have reported varying thyroid hormone levels in cases living in regions with endemic iodine deficiency, from isolated TSH elevation to biochemical hypothyroidism levels (16,20). Isolated TSH elevation (compensated hypothyroidism) was present in one child with iodine deficiency-related goiter in our study, and hypothyroidism in eight (18%).…”

Section: Discussionsupporting

confidence: 50%

Adıyaman ilinde guatrla başvuran çocuk hastalarda etiyolojik dağılım ile klinik ve laboratuvar özellikler

2020

View full text Add to dashboard Cite

Aim: The most common cause of goiter in developed countries is autoimmune diseases, while the most common cause in developing countries is iodine deficiency. We aimed to evaluate the clinical and laboratory results and etiological and demographic characteristics of cases presenting with goiter. Materials and Methods: Seventy-five patients aged between 5 and 17 years presenting with goiter between October 2016 and January 2019 were included in the study. Results: 90.7% (68) of children with goiter were female and 9.3% (7) male, the rate of goiter being 9.7-fold higher among girls. In terms of etiology, 43 patients (57.3%) were diagnosed with iodine deficiency, 25 (33.3%) with Hashimoto's thyroiditis (HT), five with Graves' disease (6.7%), and two (2.7%) with thyroid hormone resistance (THR). Mean ages were 13.7±2.1 years in the iodine deficient cases, 13.7±2.7 in the HT group, 14.3±1.4 in the Graves' disease patients, and 8.2±2.3 in the patients with THR. The highest mean urinary iodine level among iodine deficient patients was 45±27.1 (12.10-84.13) μg/L in Adıyaman center, while the lowest value was determined in Gerger district at 16.8±3.1 (14.27-20.25) μg/L, and 11 patients were diagnosed with mild iodine deficiency, 20 with moderate deficiency, and 12 with severe deficiency. Conclusion:Iodine deficiency was the most common cause of goiter in children in the province of Adıyaman, followed by autoimmune thyroid gland diseases such as Graves' disease and HT. This study shows that iodine deficiency remains still as a problem in our province.

show abstract

Section: Discussionsupporting

confidence: 50%

Adıyaman ilinde guatrla başvuran çocuk hastalarda etiyolojik dağılım ile klinik ve laboratuvar özellikler

2020

View full text Add to dashboard Cite

show abstract

“…However, in many studies, normal levels of serum TSH have been reported, despite iodine deficiency. 7,8 Children with hyperthyroidism feel nervous, moody, weak and tired. Delay of normal development and growth can lead to intellectual impairment.…”

Section: Original Articlementioning

confidence: 99%

Thyroid Hormone Status of School Going Children in An Urban Area of Chattogram, Bangladesh

Rahman

Choudhury

Hira³

2023

IAHS Med. J.

View full text Add to dashboard Cite

Background: Thyroid gland is the endocrine organ that secretes hormones namely, Triiodothyronine (T3) and Thyroxine hormone (T4). T3 and T4 are released in relation to the message of tropic hormone TSH, by the anterior pituitary. Absences as well as excess of thyroid hormones have harmful impacts on the overall health condition like physical and mental impediment. Poor intelligence leading to poor academic performance is frequently observed in hypothyroid children. The study was aimed to estimate serum T3, T4 and TSH levels of a group of school going children in urban area of Chattogram, Bangladesh. Materials and methods: This cross-sectional observational study was conducted among school going children (Age: 7-12 years) of Chattogram city between January, 2022 and June 2022. Chattogram based three schools were selected by convenient sampling. A total of 500 blood samples of children were collected and serum T3, T4 and TSH levels were measured. Estimation of T3 and T4 were done by Radioimmunoassay (RIA) and estimation of TSH was done by Immunoradiometric assay (IRMA) in the in Vitro laboratory. Results: Among 500 children, the estimated mean ±SD serum T3 hormone level was2.46±0.79 (Range: 1.27-5.51) nmol/L, mean ±SD serum T4 hormone level was 141.99±32.77 (Range: 86.21-239.05) nmol/L and mean ±SD serum TSH hormone level was 1.58±1.04 (Range: 0.30-3.02) mIU/L. Conclusion: Thyroid hormone status of the study group children was found within normal limits. However, regular screening of children is suggested to identify the subclinical and unreported clinical cases, so that theiroptimum growth and development are ensured. IAHS Medical Journal Vol 5(2), Dec 2022; 67-69

show abstract

Thyroid function tests of iodine deficiency goiter can mimic thyroid hormone resistance alpha

Pillai

Quintos

2022

Journal of Pediatric Endocrinology and Metabolism

View full text Add to dashboard Cite

Objectives Iodine deficiency goiter can develop in children on a restrictive diet and most have normal thyroid function. We report a 6-year-old girl with iodine deficiency goiter with thyroid function studies mimicking thyroid hormone resistance alpha. Thyroid hormones mediate its effects through thyroid hormone receptors alpha and beta. Biochemical picture of low/low-normal T4 and high/high-normal T3 levels, variably reduced reverse T3 and normal TSH is characteristic of thyroid hormone resistance alpha. Case presentation A 6-year-old girl, born out of non-consanguineous marriage presented with goiter of 1.5 years duration. She was without symptoms of thyroid dysfunction. The patient was evaluated at one year of age for macrocephaly with cranial ultrasound which was normal. She had normal growth and development. Patient was vegan and was not on any medications or supplements. Laboratory work up showed TSH 5.03 uIU/mL (0.34–5.5), FT4 0.3 ng/dL (0.58–1.2), FT3 5.3 pg/mL (2.5–3.9), total T3 258 ng/dL (94–241), reverse T3 <5.0 ng/dL (8.3–22.9) and negative thyroglobulin antibody and thyroid peroxidase antibody. Thyroglobulin level was 1,098.8 ng/mL (<13 ug/L), and urine iodine 15.8 ug/L (<100 ug/L) confirming a diagnosis of iodine deficiency goiter. Patient was started on iodine supplements, 150 ug daily and repeat work up 3 months later were TSH: 2.717 uIU/mL, T3, total 182 ng/dL, T4, total 9.3 ug/dL, FT 4 2.1 ng/dL. Conclusions Iodine deficiency goiter may present with low FT 4, elevated T3 and normal TSH mimicking thyroid hormone resistance alpha and should be considered in children on restrictive diet.

show abstract

Thyroid Hormone Profile in Children with Goiter in an Endemic Goiter Area

Cited by 3 publications

References 3 publications

Adıyaman ilinde guatrla başvuran çocuk hastalarda etiyolojik dağılım ile klinik ve laboratuvar özellikler

Adıyaman ilinde guatrla başvuran çocuk hastalarda etiyolojik dağılım ile klinik ve laboratuvar özellikler

Thyroid Hormone Status of School Going Children in An Urban Area of Chattogram, Bangladesh

Thyroid function tests of iodine deficiency goiter can mimic thyroid hormone resistance alpha

Contact Info

Product

Resources

About