Thyrotropin and Cyclic Nucleotide Effects on Prostaglandin Levels in Isolated Thyroid Cells

Burke, Gerald; Chang, Lucy; Szabó, Márta

doi:10.1126/science.180.4088.872

Cited by 59 publications

(7 citation statements)

References 16 publications

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“…Like TSH, E-type prostaglandins stimulated adenyl cyclase in various thyroid prep arations (207)(208)(209)(210)(211)(212)(213). Both TSH and long acting thyroid stimulator (LATS) increased the concentration of prostaglandins in isolated thyroid cells (214)(215)(216) and thyroid glands (217). Some evidence supporting this hypothesis has appeared: 1.…”

Section: Hndocrine Glandsmentioning

confidence: 99%

Prostaglandins

Samuelsson¹,

Granström²,

Green³

et al. 1975

Annu. Rev. Biochem.

567

170

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Section: Hndocrine Glandsmentioning

confidence: 99%

Prostaglandins

Samuelsson¹,

Granström²,

Green³

et al. 1975

Annu. Rev. Biochem.

567

170

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“…Interactions of the prostaglandins with cyclic nucleotides have been observed in many situations (Silver & Smith, 1975). Examples include alterations in adenylate cyclase activity by prostaglandins (Dalton & Hope, 1974) and modulation of PG synthesis by cyclic AMP through changes in membrane phospholipase activity (Burke, Chang & Szabo, 1973;Hamprecht, Jaffe & Philpott, 1973;Dalton & Hope, 1974). Prostaglandin CaZf interactions have also been reported (Ramwell & Shaw, 1970;Carafoli, Malmstrom, Sigel & Crompton, 1976;Rubin & Laychock, 1978).…”

Section: Introductionmentioning

confidence: 95%

Regulation of 25-Hydroxy-Vitamin D-1α-Hydroxylase in Chick Isolated Renal Tubules: Effects of Prostaglandin E2, Frusemide and Acetylsalicylic Acid

et al. 1981

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1. Isolated renal tubules were prepared from vitamin D-deficient chicks. The effects of added prostaglandin E2 (PGE2) and agents which modify prostaglandin metabolism on the metabolism of 25-hydroxy-vitamin D3 were studied. 2. Frusemide (0.1 mmol/l) raised the prostaglandin E (PGE) content of the tubule incubation medium; it significantly increased 1,25-dihydroxy-vitamin D3 [1,25-(OH)2D3] production from 25-hydroxy-vitamin D3 [25-(OH)D3] and significantly inhibited the net production of 24,25-dihydroxy-vitamin D3 [24,25-(OH)2D3]. 3. Acetylsalicylic acid (aspirin; 0.1 mmol/l) decreased the PGE content of the tubule incubation medium and significantly inhibited 1,25-(OH)2D3 production. 4. In the presence of 1,25-(OH)2D3, 4 h exposure of tubules from vitamin D-deficient chicks to concentrations of PGE2 between 2.8 X 10(-6) and 2.8 X 10(-8) mol/l significantly enhanced 1,25-(OH)2D3 production. 5. It is concluded that, in view of the effects of modulation of endogenous prostaglandin levels by frusemide in aspirin, and the stimulatory effect of exogenous PGE2, prostaglandins should be considered potential regulators of the renal 25-hydroxy-vitamin D-1 alpha-hydroxylase [25-(OH)D-1 alpha-hydroxylase] enzyme.

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“…The mechanism of action of PGEj may be related to the cyclic AMP system as has been reported in other neuronal systems (13,14). In those systems, PGEj acts as a modulator of the action of synaptic transmitters such as norepinephrine (NE) or dopamine (DA) possibly by preventing the activation of the adenyl cyclase system (15).…”

Section: Discussionmentioning

confidence: 98%

Central Effect of Prostaglandin E₁(PGE₁on Prolactin Release

1974

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PGE, or PGE 2 injected iv at different doses (5, 20 or 50 fig/100 g body wt) in ovariectomized rats failed to modify plasma prolactin levels 20, 60 or 90 min after injection. The diluent (95% ethanol) was also ineffective. Third ventricular injection of PGE, (5 fig in 5 fi\ 95% ethanol: 0.02% Na 2 CO 3 , 1:9) in ovariectomized rats induced a marked increase in plasma prolactin levels 15 min later. Levels then declined but were still elevated at 30 min. At 60 min they were not different from the initial values. PGE 2) PGF lQ or PGF 2a at the same dose failed to modify plasma prolactin at any time interval studied. The diluent also did not alter plasma prolactin. Intraventricular injection of different doses of PGE, (0.5, 1.0, 2.5 or 5.0 fig in 5 fil) induced a dose-related increase of plasma prolactin 15 min after the injection. In ovariectomized, estrogen-treated rats (estradiol benzoate, Eb, 10 fig, SC, 48 hr before), PGE, increased plasma prolactin 15 min later, in spite of the elevated initial plasma prolactin levels induced by the estrogen treatment. PGE 2 , PGF la) PGF 2a or the diluent were again ineffective. Intrapituitary injection of PGE, (2.5 fig in 2.5 fi\ into each lobe) in ovariectomized rats slightly increased plasma prolactin levels at 15 min (p < 0.05). Similar injections of PGE 2 did not alter plasma prolactin at any time interval studied. Intrapituitary injections of PGE, or PGE 2 in ovariectomized estrogen-treated rats at the same dose used before failed to increase plasma prolactin. These results indicate that PGE, can stimulate prolactin release by acting on the central nervous system and that this effect is not inhibited by estrogen treatment. PGE 2 , PGF, a and PGF 2a appear to be ineffective. Under certain conditions, PGE, may also stimulate prolactin release by acting on the adenohypophysis, but this effect was inhibited by estrogen pretreatment. (Endocrinology 95: 613, 1974) P ROSTAGLANDIN participation in a wide variety of endocrine and metabolic systems is well documented (1-3); however, little is known about the role played by prostaglandins in the nervous system (4) or in the neural control of pituitary secretion.The first demonstration that prostaglandins could modify the release of pituitary hormones by acting directly on the central nervous system was made by Hedge (5), who reported that PGEi or PGF l a microinjected into the median eminence induced a release of ACTH. In this paper we report in detail results which indicate that PGE X can act on both the CNS and anterior pituitary gland to release prolactin. Preliminary reSprague-Dawley female rats (Simonsen Laboratories, Gilroy, California), weighing 230-300 g, were used. All animals were ovariectomized upon arrival and housed under controlled conditions of light (14 hr on and 10 hr off) and temperature (24 C). Purina rat chow and water were available ad libitum.Intravenous injections. Two weeks after ovariectomy the animals were lightly anesthetized with ether and initial blood samples (0.8-0.9 ml) were drawn from the external j...

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Thyrotropin and Cyclic Nucleotide Effects on Prostaglandin Levels in Isolated Thyroid Cells

Cited by 59 publications

References 16 publications

Prostaglandins

Prostaglandins

Regulation of 25-Hydroxy-Vitamin D-1α-Hydroxylase in Chick Isolated Renal Tubules: Effects of Prostaglandin E2, Frusemide and Acetylsalicylic Acid

Central Effect of Prostaglandin E₁(PGE₁on Prolactin Release

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Thyrotropin and Cyclic Nucleotide Effects on Prostaglandin Levels in Isolated Thyroid Cells

Cited by 59 publications

References 16 publications

Prostaglandins

Prostaglandins

Regulation of 25-Hydroxy-Vitamin D-1α-Hydroxylase in Chick Isolated Renal Tubules: Effects of Prostaglandin E2, Frusemide and Acetylsalicylic Acid

Central Effect of Prostaglandin E1(PGE1on Prolactin Release

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Central Effect of Prostaglandin E₁(PGE₁on Prolactin Release