Thyroid tuberculosis – role of PCR in diagnosis of a rare entity

Gupta, Neeti; Sharma, Kshitij; Barwad, Adarsh; Sharma, Manisha; Rajwanshi, Arvind; Dutta, Pradip Kumar; Sharma, Atul

doi:10.1111/j.1365-2303.2010.00830.x

Cited by 20 publications

(21 citation statements)

References 23 publications

(26 reference statements)

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“…However in some literature, AFB and culture analysis may not show tuberculosis and PCR can confirm TB in only 55% of the cases. 14,15 In this case, there were no signs and symptoms suggestive of other foci of TB in the body. The demonstration of epithelial cell granulomas with Langerhans giant cells and central caseation necrosis on histopathologic examination made the diagnosis of thyroid tuberculosis.…”

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confidence: 64%

Tuberculous Abscess of the Thyroid

Uyking-Naranjo

Cruz

Jasul

et al. 2012

JAFES

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Tuberculosis (TB) of the thyroid gland is rare, with acute abscess formation being the least common form of presentation. As such, TB of the thyroid may be overlooked as an initial clinical impression. A careful approach by history, physical examination, laboratory testing and radiologic imaging may aid in defining the etiology of the thyroid abscess, but these remain nonspecific. An accurate diagnosis may only be made by histologic examination. We present a case of a tuberculous abscess of the thyroid gland in a 37-year-old female. TB of the thyroid should also be considered when evaluating patients presenting with a painful thyroid nodule.

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confidence: 64%

Tuberculous Abscess of the Thyroid

Uyking-Naranjo

Cruz

Jasul

et al. 2012

JAFES

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“…The presence of MGC, caseous necrotic granulomas are typical of this disease [8]. Many authors suggest that MB confirmation techniques must be performed, either using ZNS, specific cultures for MB, or PCR for M. tuberculosis , with the latter being a reliable diagnostic method [2, 10]. If FNAC is non-diagnostic, a post-thyroidectomy biopsy should be considered; in this case, the presence of MGC, lymphocytic infiltration and typical granulomas will confirm the diagnosis [3, 8].…”

Section: Discussionmentioning

confidence: 99%

Incidental finding of a primary thyroid tuberculosis

Ortiz-Flores

Gioia

Montánez-Fernández

et al. 2017

Oxford Medical Case Reports

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Thyroid tuberculosis (TT) is a very rare condition, even in countries where tuberculosis is endemic. However, the prevalence of tuberculosis has increased worldwide and thyroid involvement can be a primary manifestation of the disease. We present the case of a 43-year-old patient with this diagnosis and perform a review of the related literature. After searching for similar case reports in Western Europe since 2010 we identified six cases in four countries. TT should be considered in the differential diagnosis of a thyroid nodule. Fine-needle aspiration cytology and polymerase chain reaction are useful tools as preoperative diagnosis. Typical caseous necrotic granulomas are the hallmark in biopsy.

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“…Acid-fast bacilli staining may not detect tubercular bacilli [18]. In such cases PCR can be done [19]. The confirmatory diagnosis of tuberculosis of thyroid by fine needle aspiration cytology can avoid unnecessary thyroid surgery for histopathological confirmation.…”

Section: Discussionmentioning

confidence: 99%