Thyroid Tuberculosis Mimicking Carcinoma: Report of Two Cases

Al-Mulhim, Abdulmohsen A.; Zakaria, Hazem; Hadi, Maha S. A. Abdel; Al-Mulhim, Fatma A.; Al-Tamimi, Dalal M.; Wosornu, Ladé

doi:10.1007/s005950200214

Cited by 28 publications

(33 citation statements)

References 19 publications

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“…8 Cervical lymphadenopathy has been reported, but signs of tuberculosis elsewhere in the body are rarely found. 1 In our study, one case had widespread tuberculous lymphadenopathy, whereas the other had isolated thyroid involvement.…”

Section: Discussionmentioning

confidence: 93%

“…There is also a rare isolated variety of thyroid tuberculosis that may give rise to a solitary nodule mimicking carcinoma, cold abscess with discharging sinus, diffuse goiter, or, very uncommonly, an acute abscess. 1 The clinical presentation of thyroid tuberculosis is nonspecific and the diagnosis is usually a surprise at pathological examination. 2,3 An accurate diagnosis of thyroid tuberculosis can avoid unnecessary thyroidectomies.…”

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confidence: 99%

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Tuberculous abscess of the thyroid gland: A report of two cases

Kang

Ojili

Khandelwal

et al. 2006

J of Clinical Ultrasound

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Section: Discussionmentioning

confidence: 93%

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confidence: 99%

Tuberculous abscess of the thyroid gland: A report of two cases

Kang

Ojili

Khandelwal

et al. 2006

J of Clinical Ultrasound

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“…20 In the event that pain is absent, tuberculous thyroiditis can often be mistaken for carcinoma. [21][22][23] It is important to note that tuberculous thyroiditis may coexist with thyroid carcinoma in the same patient. [24][25][26] The diagnosis is mainly made by ultrasound guided fine-needle aspiration cytology, a diagnostic step that helps to avoid unnecessary surgery.…”

Section: Discussionmentioning

confidence: 99%

Primary tuberculosis of the thyroid gland

Zendah

Daghfous

Mrad

et al. 2008

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Thyroid tuberculosis is a rare disease even in countries in which tuberculosis (TB) constitutes an endemic disorder. The diagnosis is often difficult as the clinical presentation has no distinct characteristics. We report a 47-year-old woman who presented with a painful nodular swelling of the neck, confirmed by physical examination and sweating. Ultrasonography disclosed nodules of the pyramidal lobe with cystic change, and bilateral multiple hypoechogenic lymph nodes along the jugular and carotid chains. Thyroid function tests were in the normal range, there were no signs of inflammation and the tuberculin test was negative. There was no evidence of tuberculosis in any other organ. The patient had surgery in which the pyramidal lobe was removed. Microscopic examination of the thyroid parenchyma and the excised lymph node revealed necrotizing epithelioid granulomas with Langhans' giant cells. The diagnosis of thyroid tuberculosis was therefore made. The patient was put on isoniazid, rifampicin, ethambutol and pyrazinamid for the subsequent 2 months and was subsequently given isoniazid and rifampicin for the subsequent 6 months with a favourable outcome. Although seldom observed, tuberculosis should be kept in mind in the differential diagnosis of nodular lesions of the thyroid.

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“…low density centre and thin margin of high density evoked pyogenic membrane) resembled a retropharyngeal abscess. Several cases of tuberculous granuloma in thyroid gland imitating cancer have been published (1,2,3). Cases of anaplastic thyroid cancer, or more precisely lymph node metastasis of thyroid cancer, resembling a retropharyngeal abscess, are rare.…”

Section: Discussionmentioning

confidence: 99%

Unusual Manifestation of Anaplastic Thyroid Cancer

Haas

Čelakovský

Brtková

et al. 2008

Acta Med. (Hradec Kralove, Czech Repub.)

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The most frequent clinical manifestation of anaplastic thyroid cancer is a rapidly enlarging mass at the frontal part of the neck. It is accompanied by severe compression symptoms such as dysphagia and dyspnoea with hoarseness, which could be partially due to paresis of the recurrent laryngeal nerve. We treated a patient with symptoms consistent with a retropharyngeal abscess -swelling of the posterior pharyngeal wall, odynophagia, pain in the left side of the neck, elevated inflammatory markers. The diagnosis of anaplastic thyroid cancer was unexpectedly made after surgery and a subsequent histological examination. Case reportAn 80-year-old woman was referred to Dpt. of Otolaryngology, Head and Neck Surgery, Charles University Medicine Faculty, Teaching Hospital in Hradec Králové from a local hospital where she was treated for suspected urine infection. She suffered from chronic hypertension and insulin-dependent diabetes mellitus and diabetes mellitus was not perfectly compensated. Regarding her family history, there was one relevant piece of information concerning the death of her daughter at the age of 52 from pancreatic cancer.Odynophagia and pain in the left side of the neck appeared during the hospitalization in the local hospital accompanied with significant weight loss. Inflammation markers were significantly elevated (C-reactive protein 239 mg/l, leucocytes 25x10 9 /l). Due to the clinical findings, a computer tomography investigation (CT) was performed and a retropharyngeal abscess was found as well as hypertrophy of the left lobe of the thyroid gland. The existence of a tumour was considered as well and the patient was transferred to Dpt. of Otolaryngology, Head and Neck Surgery, Charles University Medicine Faculty, Teaching Hospital in Hradec Králové.At the time of admission the patient had pronounced swelling of the left side of her neck. It seemed to be the left lobe of the thyroid gland with retrosternal extension. We could also see swelling of the posterior pharyngeal wall, Summary: Introduction: The authors present a rare case of a patient with symptoms consistent with retropharyngeal abscess. The diagnosis of anaplastic thyroid cancer was made after surgery and subsequent histological examination. Case report: An 80-year-old woman was referred to Dpt. of Otolaryngology, Head and Neck Surgery, Charles University Medicine Faculty, Teaching Hospital in Hradec Králové with odynophagia and pain in the left side of the neck. The patient had pronounced swelling of the left side of her neck. We could also see swelling of the posterior pharyngeal wall, more pronounced on the left side. Inflammation markers were markedly elevated. Administration of antibiotics intravenously (amoxicillin combined with clavulan acid and gentamicin) was started. A computer tomography investigation (CT) was performed and a retropharyngeal abscess was found. The existence of a tumour was considered as well. An acute endoscopic examination and a puncture of the retropharyngeal space at the site of the swelling were performed,...

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Thyroid Tuberculosis Mimicking Carcinoma: Report of Two Cases

Cited by 28 publications

References 19 publications

Tuberculous abscess of the thyroid gland: A report of two cases

Tuberculous abscess of the thyroid gland: A report of two cases

Primary tuberculosis of the thyroid gland

Unusual Manifestation of Anaplastic Thyroid Cancer

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