Thyroid Storm Due to Functioning Metastatic Thyroid Carcinoma in a Burn Patient

Naito, Yoshiyuki; Sone, T; Kataoka, K.; Sawada, Masashi; Yamazaki, Kanami

doi:10.1097/00000542-199708000-00034

Cited by 32 publications

(15 citation statements)

References 6 publications

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“…Most cases of thyroid storm are caused by the presence of some triggering condition in conjunction with an underlying thyroid condition, usually untreated or uncontrolled Graves' disease, but very rarely other thyrotoxic disorders such as destructive thyroiditis, toxic multinodular goiter, TSH-secreting pituitary adenoma, hCG-secreting hydatidiform mole, or metastatic thyroid cancer [13][14][15][16][17]. Thyroid storm can also be caused by medical precipitants such as thyroidectomy, nonthyroid surgery, radioiodine therapy, exposure to excess iodine in patients with hyperthyroidism, or excess thyroid hormone ingestion [1][2][3][4].…”

Section: Diagnostic Challenges For Thyroid Stormmentioning

confidence: 99%

2016 Guidelines for the management of thyroid storm from The Japan Thyroid Association and Japan Endocrine Society (First edition)

et al. 2016

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Section: Diagnostic Challenges For Thyroid Stormmentioning

confidence: 99%

2016 Guidelines for the management of thyroid storm from The Japan Thyroid Association and Japan Endocrine Society (First edition)

et al. 2016

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“…In one report, a thyroid storm also resulted from a functioning metastatic thyroid carcinoma in a burn patient, presumably due to tissue necrosis 17. Direct trauma to metastatic functional thyroid tissues, had not, however—to our knowledge—been reported before to cause thyrotoxicosis or thyroid storm.…”

Section: Discussionmentioning

confidence: 94%

Recurrent thyroid storm induced by heretofore unrecognised causes in a patient with thyroid cancer

Raef¹,

Dahhan

Ahmed

et al. 2009

Case Reports

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An unusual encounter of a thyroid storm, on two separate occasions, is reported in a patient with metastatic differentiated thyroid cancer following initially direct trauma to, and later tumour embolisation of, a metastatic skeletal lesion. Shortly after a fall, our patient presented with pain and swelling in the right shoulder, high fever, change in mental status, anorexia, nausea and vomiting, tachycardia and dehydration. The laboratory tests were consistent with hyperthyroidism. As the patient improved, arterial embolisation of the large right humerus metastasis was performed to decrease the tumour burden. The patient, however, developed a similar clinical and biochemical picture to that at her presentation, with a very high free thyroxine (T(4)) level, a few days after successful embolisation. Treatment of the thyroid storm was initiated and the patient eventually improved. Awareness of such occurrences is helpful in early diagnosis and effective management of this potentially fatal complication.

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“…More rarely other thyrotoxic disorders, such as destructive thyroiditis, toxic multinodular goiter, TSH-secreting pituitary adenoma, hCG-secreting hydatidiform mole or metastatic thyroid cancer, cause TS (9)(10)(11)(12). Triggering conditions could be drugs such as amiodarone, sorafenib, ipilimumab and inappropriate hormone ingestion (13)(14)(15) or medical settings as surgery, radioiodine therapy and exposure to excess iodine in patients with hyperthyroidism (2,5,16,17).…”

Section: Predictive Featuresmentioning

confidence: 99%