Thyroid orbitopathy, an overview with special attention to the role of radiotherapy

Vilar-González, Santiago; Oliveira, Cristina Lamas; Fagúndez-Vargas, María A.; Núñez-Quintanilla, Ana T.; Pérez-Rozos, A.; Merayo‐Lloves, Jesús; Escobar-Barranco, José J.; Rico-Pérez, José M.

doi:10.1016/j.endoen.2015.04.002

Cited by 3 publications

(3 citation statements)

References 64 publications

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“…Several studies confirmed the efficacy of orbital irradiation as based on the meta-analysis by Viani et al [28], although Otsuka et al [29] found no significant differences in terms of the therapeutic effect between groups treated with steroid pulses with or without orbital irradiation. There are no large RCTs comparing the advantage of this combined treatment over IV glucocorticosteroids alone [28,30,31]. As reported in a randomised study, lower orbital doses of 12 Gy were sufficient in reducing soft tissue changes, and higher doses were required in patients with ocular motility impairment [32].…”

Section: Discussionmentioning

confidence: 98%

Wcześniejsze leczenie choroby Gravesa lekami tyreostatycznymi lub radiojodem nie wpływa na skuteczność leczenia immunosupresyjnego orbitopatii tarczycowej

Jagiełło-Korzeniowska¹,

Sokołowski

Krzentowska-Korek³

et al. 2016

Endokrynologia Polska

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Introduction: We studied the efficacy of immunosuppressive treatment of GO in a group of patients who had been treated with antithyroid drugs (the ATD group) and in another group that had undergone radioiodine therapy (the 131-I group). Material and methods: A total of 214 patients with exacerbation of GO were studied; the ATD group consisting of 168 patients, and the 131-I group consisting of 46 patients. All patients were treated with methylprednisolone IV pulses (total dose 8.0 g) followed by orbital irradiation (20 Gy in 10 fractions). CAS and IO indices, TSH, fT4, and TRAb levels were evaluated prior to, and 1, 6, and 12 months after treatment.

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Section: Discussionmentioning

confidence: 98%

Wcześniejsze leczenie choroby Gravesa lekami tyreostatycznymi lub radiojodem nie wpływa na skuteczność leczenia immunosupresyjnego orbitopatii tarczycowej

Jagiełło-Korzeniowska¹,

Sokołowski

Krzentowska-Korek³

et al. 2016

Endokrynologia Polska

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“…However, orbital radiotherapy could also be used as a first-line treatment in combination with i.v. corticosteroid when significant involvement of the retroorbital muscles is present determining progressive diplopia, although randomised clinical trials supporting this possibility are still lacking ( 42 , 43 ).…”

Section: Discussionmentioning

confidence: 99%

Circulating miR-146a predicts glucocorticoid response in thyroid eye disease

Manso,

Censi,

Clausi

et al. 2023

European Thyroid Journal

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Objective: Thyroid eye disease (TED) is an immune-mediated disorder of the eye. Intravenous glucocorticoid (GC) is the first-line treatment for patients with active moderate-to-severe TED. However, the response rate is between 50 and 80%. There are still no simple and reliable markers of responsiveness to GC therapy. We aimed to explore the possible role of miR-146a and miR-21 as predictors of responsiveness to GC treatment in TED. Methods: We carried out a prospective longitudinal study on 30 consecutive adult patients with active moderate-to-severe TED and eligible for GC therapy. All patients received the standard GC treatment with methylprednisolone iv. In cases of progressive worsening of Gorman Score for diplopia or with duction restriction <30° in at least two consecutive controls patients also underwent orbital radiotherapy. Response to GC treatment was defined as a decrease of 2 or more points in the clinical activity score (CAS) or CAS <4/10 at 24 weeks. Circulating miRNAs were extracted from patients’ serum and quantified by real time PCR. Results: Twenty-three (77%) patients responded to GC. Thyroid surgery, higher CAS, greater proptosis and higher pre-treatment circulating levels of miR-146a emerged as predictive factors of responsiveness to GC. A ROC analysis revealed that miR-146a could predict responsiveness to GC with a positive predictive value of 100%. Conclusion: This is the first study investigating the role of pre-treatment circulating miR-21 and miR-146a to predict responsiveness to GC in TED. miR-146a emerged as a simple, objective, new marker of GC sensitivity that could be used to avoid ineffective administration of GC therapy to TED patients.

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“…Guatr, orbitopati ve dermopati klasik üçlüsü ile anılır. Bu semptomlar; hastalığın gelişimi ile birlikte veya tek başlarına ve bağım-sız olarak ortaya çıkabilir 3 . Hastaların %3 ila %5'inde şiddetli oftalmopati gelişir ve hastaların yaşam kalitesini önemli derecede düşürür 4 .…”

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Graves Oftalmopati Tanılı Olguların Yoğunluk Ayarlı ve Üçboyutlu Konformal Retro-Orbital Radyoterapi Planlarının Dozimetrik Olarak İncelenmesi

Bolat

Çetintaş

Tunç

et al. 2018

Uludağ Üniversitesi Tıp Fakültesi Dergisi

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ÖZET Graves oftalmopati (GO) tanılı olguların radyoterapi ile tedavisinde; karşılıklı lateral üç boyutlu konformal radyoterapi (3BKRT) ve yoğunluk ayarlı radyoterapi (YART) teknikleri kullanılarak hedef hacmin ve riskli organların aldığı dozların karşılaştırılması amaçlanmıştır. Çalışmada; GO tanılı 15 hastaya fraksiyon dozu 2 Gy toplam doz 20 Gy olacak şekilde 3BKRT ve YART tekniği ile iki ayrı tedavi planı oluşturuldu. Planlanan hedef hacmin (PTV) ve riskli organların aldığı doz değerleri karşılaştırıldı ve homojenite indeksi (HI), konformite indeksi (CI) değerleri hesaplanıp Monitor Unit (MU) değerlerine bakıldı. PTV'nin D95% (p=0,583) değerinde iki teknik arasında fark görülmedi; D98% (p<0,001) değerinde YART tekniğinin üstünlüğü görüldü. Sonuç olarak; hastanın katarakt olmasına neden olabilecek dozlardan kaçınmak istendiğinden, kullanılan karşılıklı lateral açıdan dolayı 3BKRT tekniğinin daha düşük doz radyasyon aldığı söylenebilir.

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Thyroid orbitopathy, an overview with special attention to the role of radiotherapy

Cited by 3 publications

References 64 publications

Wcześniejsze leczenie choroby Gravesa lekami tyreostatycznymi lub radiojodem nie wpływa na skuteczność leczenia immunosupresyjnego orbitopatii tarczycowej

Wcześniejsze leczenie choroby Gravesa lekami tyreostatycznymi lub radiojodem nie wpływa na skuteczność leczenia immunosupresyjnego orbitopatii tarczycowej

Circulating miR-146a predicts glucocorticoid response in thyroid eye disease

Graves Oftalmopati Tanılı Olguların Yoğunluk Ayarlı ve Üçboyutlu Konformal Retro-Orbital Radyoterapi Planlarının Dozimetrik Olarak İncelenmesi

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