Wcześniejsze leczenie choroby Gravesa lekami tyreostatycznymi lub radiojodem nie wpływa na skuteczność leczenia immunosupresyjnego orbitopatii tarczycowej

Jagiełło-Korzeniowska, Agnieszka; Sokołowski, Andrzej; Krzentowska-Korek, Anna; Miklaszewska, Grażyna; Bałdys-Waligórska, Agata

doi:10.5603/ep.2016.0073

Cited by 1 publication

(1 citation statement)

References 28 publications

(43 reference statements)

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“…In our study, the final outcome of ivGCs was not associated with initial or final TRAB levels, which may suggest that it cannot be used as a prognostic marker in GO treatment, which would support some previous reports [31, 32] but is discordant with others [7, 8, 23]. Jang et al noticed that various GO and GD durations and different status of hyperthyroidism treatment have a significant influence on TRAB levels and may cause discordance between the results [23].…”

Section: Discussionsupporting

confidence: 89%

Clinical utility of TSH receptor antibody levels in Graves’ orbitopathy: a comparison of two TSH receptor antibody immunoassays

Bluszcz¹,

Bednarczuk²,

Bartoszewicz³

et al. 2018

cejoi

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IntroductionThyroid stimulating hormone (TSH) receptor antibodies (TRAB) play a role in the development of Graves’ orbitopathy (GO), and measurements of the TRAB level may be helpful in monitoring GO treatment.Aim of the studyTo assess the correlation of TRAB levels measured with two different assays: third-generation TRAB assay (TRAB Cobas) and novel Immulite assay (TRAB Immulite), in patients with moderate-to-severe GO treated with intravenous glucocorticoid pulse therapy (ivGCs).Material and methodsForty patients with active, moderate-to-severe GO underwent clinical and laboratory evaluation before, in the middle, and after ivGCs therapy. The correlation of TRAB levels with GO signs was evaluated. Laboratory and clinical findings were compared according to the response to ivGCs. TRAB concentration was measured with Immulite TSI assay and with Elecsys IMA.ResultsAll patients were TRAB positive in both assays at the beginning of the treatment. The decrease of both TRAB Immulite and Cobas levels in serum during ivGCs was statistically significant. We observed strong correlation between both TRAB levels before and after ivGCs. There was no statistically significant difference in antibody levels between patients with good response and no response to the treatment. We did not find any correlation between antibody levels and GO features before the therapy, but measurements during ivGCs showed comparable correlation of both TRAB levels with GO activity.ConclusionsWe found similarity between Immulite assay and third-generation TRAB assay in the assessment of patients with GO treated with ivGCs. Both TRAB levels showed comparable correlation with GO activity during ivGCs therapy.

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