Thyroid-like papillary adenocarcinoma of the nasopharynx with focal thyroglobulin expression

Özer, Serdar; Kayahan, Bahar; Cabbarzade, Cavid; Bugdayci, Meral; Kösemehmetoğlu, Kemal; Yücel, Ömer Taşkın

doi:10.1097/pat.0b013e32836536e9

Cited by 17 publications

(20 citation statements)

References 8 publications

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“…Our patient was ultimately diagnosed with biphasic LGNPPA with a prominent spindle cell component [ 6 ]. Recently, however, Ozer et al reported a TL-LGNPPA with focal thyroglobulin expression, and suggested that TL-LGNPPA shares some feature with papillary thyroid carcinoma [ 16 ]. Furthermore, they posited that some TL-LGNPPAs may represent papillary thyroid carcinomas originating from an ectopic thyroid tissue or remnants of the nasopharynx [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…Recently, however, Ozer et al reported a TL-LGNPPA with focal thyroglobulin expression, and suggested that TL-LGNPPA shares some feature with papillary thyroid carcinoma [ 16 ]. Furthermore, they posited that some TL-LGNPPAs may represent papillary thyroid carcinomas originating from an ectopic thyroid tissue or remnants of the nasopharynx [ 16 ]. Therefore, in addition to thyroglobulin, we performed immunohistochemical staining for the alternative thyroid transcription factor PAX8 [ 17 , 18 ]; this protein was not found to be positive in contrast to previously reported tumors.…”

Section: Discussionmentioning

confidence: 99%

“…A previously reported TL-LGNPPA was negative for PAX8 [ 9 ] while another was focally positive for thyroglobulin [ 16 ]. Moreover, we tested EBER, p16, and HPV because their expression had previously been reported in nasopharyngeal carcinoma [ 19 , 20 ]; however, our patient’s tumor was negative for these proteins.…”

Section: Discussionmentioning

confidence: 99%

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Biphasic low-grade nasopharyngeal papillary adenocarcinoma: a case report and literature review

et al. 2018

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BackgroundLow-grade nasopharyngeal papillary adenocarcinoma (LGNPPA) is distinctly rare. We report a patient with a uniquely biphasic LGNPPA; additionally, we review similar tumors reported in the literature.Case presentationA 56-year-old man presented with an asymptomatic pedunculated tumor in the vault of the nasopharynx, at the junction of the nasal septum and the roof, which was discovered during screening for laryngeal cancer. To obtain a definitive diagnosis, the patient underwent endoscopic endonasal surgery under general anesthesia. Immunohistochemical analysis of the tumor revealed it to be an LGNPPA with a prominent spindle cell component.ConclusionTo our knowledge, this is the fourth reported LGNPPA exhibiting a spindle cell component and the second with a prominent pathological condition. The prognosis of LGNPPA is usually excellent. Therefore, it is important for clinicians to scrutinize the lesion’s pathology to avoid unnecessary, disfiguring surgery.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Biphasic low-grade nasopharyngeal papillary adenocarcinoma: a case report and literature review

et al. 2018

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“…Immunostaining for thyroglobulin and CD15 are critical and highly recommended to distinguish these two entities [ 25 ]. However, a case of TL-LGNPPA with focal expression of thyroglobulin was recently reported [ 11 ]. Polymorphous low-grade papillary adenocarcinoma (PLGA) is more aggressive and positive for vimentin and S100-protein.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Features of Low-Grade Thyroid-like Nasopharyngeal Papillary Adenocarcinoma

Wei

Yao

et al. 2017

Cancer Res Treat

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PurposePrimary low-grade thyroid-like papillary adenocarcinomas are extremely rare neoplasms that generally originate in the nasopharynx. Here, we describe a novel case of a 15-year-old Chinese girl who was diagnosed with low-grade thyroid-like papillary adenocarcinoma, including a brief review of the literature to reveal the clinicopathological features of low-grade thyroid-like nasopharyngeal papillary adenocarcinoma.Materials and MethodsImmunohistochemistry was used to evaluate the expression of pan-cytokeratin (CKpan), cytokeratin (CK) 7, thyroid transcription factor 1 (TTF-1), vimentin, epithelial membrane antigen (EMA), thyroglobulin, CD15, S100, P40, CK20, CDX-2, glial fibrillary acidic protein (GFAP), and Ki-67. Additionally, in situ hybridization investigation was utilized to identify the presence of small Epstein-Barr virus (EBV)–encoded RNA.ResultsHistopathological analysis revealed florid proliferation of papillary structures lined by columnar epithelial cells with fibrovascular cores. Immunohistochemically, the neoplastic cells were positive for CKpan, CK7, TTF-1, vimentin, and EMA, but negative for thyroglobulin, CD15, S100, P40, CK20, CDX-2, and GFAP. The Ki-67–labeling index reached 5% in the most concentrated spot. In situ hybridization for EBV was negative.ConclusionDue to the distinct rarity of low-grade thyroid-like papillary adenocarcinomaswith a favorable clinical outcome, a nationwide effort to raise public awareness of this neoplasm is required.

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“…Interestingly, metastatic papillary thyroid carcinomas are always positive for TG, but only one reported case of TL-LGNPPA showed focal expression of TG. [ 13 ] Meanwhile, clinical manifestations, imaging results, and more comprehensive immunohistochemical staining could also exclude the possibility of metastatic papillary thyroid carcinoma as well as other metastatic carcinomas. In addition, negative expression of PSA, CDX-2, and napsin A are helpful to exclude metastatic prostate cancer, intestinal-type adenocarcinomas, and lung adenocarcinoma, respectively.…”

Section: Discussionmentioning

confidence: 99%

Primary thyroid-like low-grade nasopharyngeal papillary adenocarcinoma

Zhang¹,

Havrilla

et al. 2017

Medicine

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Rationale:Primary thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA) is an extremely rare malignant nasopharyngeal tumor with features resembling papillary thyroid carcinoma including nuclear positive expression of thyroid transcription factor-1 (TTF-1).Patient concerns:A 64-year-old male presented with nasal bleeding and a foreign body sensation of the nasopharynx. Laryngoscopy revealed a 2.0-cm broad-based mass with a smooth surface on the posterior wall of the nasopharynx. A biopsy was obtained.Diagnoses:Histopathologic examination demonstrated tumor cells arranged in both papillary and glandular architecture. The tumor cells express nuclear immunoreactivity for TTF-1. The diagnosis of TL-LGNPPA was made.Interventions:After the patient was diagnosed with TL-LGNPPA, he underwent complete surgical resection.Outcomes:There was no recurrence or evidence of metastatic disease at the 12-month follow-up.Lessons:TL-LGNPPA is easy to misdiagnose as metastatic papillary thyroid carcinoma or other relative primary adenocarcinomas. It is important to have a broad differential diagnosis and know the key features of each entity because the prognosis and clinical treatment of each may differ.

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Thyroid-like papillary adenocarcinoma of the nasopharynx with focal thyroglobulin expression

Cited by 17 publications

References 8 publications

Biphasic low-grade nasopharyngeal papillary adenocarcinoma: a case report and literature review

Biphasic low-grade nasopharyngeal papillary adenocarcinoma: a case report and literature review

Clinicopathological Features of Low-Grade Thyroid-like Nasopharyngeal Papillary Adenocarcinoma

Primary thyroid-like low-grade nasopharyngeal papillary adenocarcinoma

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