Thyroid hormones concentration in portal and peripheral blood in patients with pancreatic cancer: Preliminary study

Abstract

BACKGROUND: The prognostic value of D-dimers concentration in portal blood in patients with pancreatic cancer has been established in several studies. Thyroid hormones and their receptors, especially T3 also seems to have a specific role in process of neoplasia and metastatic spread. OBJECTIVE: The aim of the study was to look for changes of thyroid hormones concentration between portal and peripheral blood. METHODS: We included prospectively 8 patients with pancreatic cancer, without liver dysfunction, qualified to surgical treatment. D-dimers, THS, fT3, fT4 concentration was determined in blood samples from portal and peripheral vein taken intraoperatively. RESULTS: The difference and quotient of portal and peripheral concentration of D-dimers, THS, fT3 and fT4 was calculated (D-dimer-; THS-; fT3-; fT4-d and -q). The level of D-dimers measured in portal blood was > 2700 ng/mL in 3 patients. The peripheral fT3 level was significantly higher In high portal D-dimers group. FT3 change coefficients showed strong statistically significant negative correlation with portal D-dimer concentration level. CONCLUSIONS: We suggest that fT3 or its receptors can influence progression of pancreatic malignancies. The results of this study are also a new evidence that both fT3 and portal D-dimers are biologically linked to intensity of local neoplastic process. Nevertheless, deeper knowledge about portal circulation probably constitute missing part in understanding nature of pancreatic neoplasia. Investigations both on larger group and in the field of basic sciences are needed.

Gender-Specific Coagulation Profiles of Peripheral and Portal Blood May Help to Differentiate Malignant from Benign Pancreatic Tumour—Pilot Study

“…In humans, D-dimer portal concentration is proved to be higher than peripheral when comparing PDAC patients to those with benign pancreatic diseases [ 7 , 15 , 16 , 17 , 18 ]. Furthermore, in the pilot study on a small group of PDAC patients, the fT3 change coefficient (peripheral to portal blood) showed a strong statistically significant negative correlation with the portal D-dimer concentration level [ 14 ], which is in line with Durczynski et al These results allude to the existence of multiple, multidirectional, mutual bindings between cancer culture, hormonal balance, and coagulation profile. Although the influence of neoplastic disease on the body’s hormonal balance is widely recognized, it is also highly knotty.…”

“…Directly influencing the coagulation profile, especially in the portal blood, is fairly common; however, potentially disturbing the interpretation of this study results in tissue factor (TF) overexpression on the tumor cells [ 13 ]. One of its effects is well described by our D-dimer group with a high concentration in portal blood [ 7 , 14 , 15 , 16 , 17 , 18 ]; however, the other can shorten the aPTT and raise the level of fibrinogen concentration ( Figure 2 ). Our study proved that another haemostatic marker for hypercoagulability, i.e., shortened aPTT, may also help to distinguish between different types of pancreatic tumors in males.…”

Combined prognostic value of preoperative serum thyrotrophin and thyroid hormone concentration in papillary thyroid cancer

“…In TN breast cancer, fT3 may be involved in the transduction of proliferation signals 14 . Strzałka A et al found that fT3 also contributes to the development of pancreatic cancer 15 . Therefore, the predictive effect of fT3 on the recurrence of PTC should be explored further.…”

“…Strzałka A et al found that fT3 also contributes to the development of pancreatic cancer 15 . Therefore, the predictive effect of fT3 on the recurrence of PTC should be explored further.…”