Thyroid hormones and thermogenesis

Dauncey, M. J.

doi:10.1079/pns19900024

Cited by 86 publications

(57 citation statements)

References 73 publications

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“…Thyroid hormones, especially T 3 , are known to be thermogenic. They stimulate oxidative phosphorylation and ATP exportation [12,14] and mitochondria biogenesis [9]. Their decreased concentrations at high temperature [21,32] are consistent with the reduction in heat production in observed in such conditions [23,27].…”

Section: Discussionsupporting

confidence: 62%

“…Several studies indicate that both rectal and skin temperatures are increased in growing pigs [11,17] and in lactating sows [24,26] under high temperatures. In addition, the decrease in energy metabolism and feed intake may have effects on hormones involved in the regulation of thermogenesis (thyroid hormones) [9], growth (IGF-1) [4,10] and feed intake (leptin) [3]. However, studies usually deal with single time-point measurements, and less data are available in young pigs [28].…”

Section: Introductionmentioning

confidence: 99%

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Effects of high temperature on body temperature and hormonal adjustments in piglets

2002

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-Effects of a high (33°C) or thermoneutral (23 °C) temperature on body temperature and endocrine parameters were studied in weaned piglets. Rectal and skin temperatures were measured in four ad libitum fed animals per temperature during three weeks. After this acclimation period, 11 blood samples were withdrawn on a 24-h period. Over the acclimation period, rectal and skin temperatures were 0.6 and 2.9°C higher, respectively, at 33°C than at 23°C (P < 0.01), this change occurring from the 1st day at 23 or 33°C. A tendency of serum leptin concentrations to be lower after meals at 33°C than at 23°C was also displayed (P = 0.09). Plasmatic concentrations in Insulin-like growth factor I and thyroxine were decreased at 33°C relative to 23°C (P < 0.01 and P < 0.06, respectively), and triiodothyronine concentrations tended to be lower at 33°C than at 23°C (P = 0.1), which could account for the lower heat production and growth observed in pigs exposed to high temperatures.piglet / heat exposure / body temperature / thyroid hormones / IGF-I Résumé -Effets d'une température ambiante élevée sur la température corporelle et les ajustements hormonaux chez le porcelet sevré. Les effets d'une température ambiante élevée (33°C) ou thermoneutre (23°C) sur la température corporelle et le statut hormonal sont étudiés chez le porcelet sevré. Les températures rectale et cutanée sont mesurées sur 4 animaux par tempé-rature, nourris à volonté et acclimatés à la température expérimentale pendant trois semaines. Après cette période, les paramètres sanguins sont mesurés sur 11 échantillons prélevés sur un nycthémère. Au cours de la période d'acclimatation, les températures rectale et cutanée sont rapidement supérieures à 33°C qu'à 23°C, respectivement de 0,6 et 2,9°C (P < 0,01). Les concentrations sériques en leptine tendent à être inférieures à 33°C à l'état nourri (P = 0,09). Les taux d'Insulin-like growth factor I et thyroxine plasmatiques sont plus faibles à 33 qu'à 23°C (respectivement P < 0,01 et P < 0,06), et les concentrations en triiodothyronine tendent à être inférieures à 33°C (P = 0,1), en accord avec la production de chaleur et la croissance plus faible de ces animaux au chaud.porcelet / chaleur / température corporelle / hormones thyroïdiennes / IGF-I Reprod. Nutr. Dev. 42 (2002) 45-53 45

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Section: Discussionsupporting

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Effects of high temperature on body temperature and hormonal adjustments in piglets

2002

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“…Female rabbits of generation 16 had a quicker response to heat challenge than V36. They reduced both the DE intake and the plasma concentrations of glucose and total T 3 (both positively correlated with energy intake; Dauncey, 1990;Rommers et al, 2004;Brecchia et al, 2006), in the 1st reproductive cycle, with respect to NC female rabbits. In contrast, in the 1st reproductive cycle, V36 female rabbits did not reduce glucose and total T 3 concentrations, and maintained a higher PFT at weaning.…”

Section: Discussionmentioning

confidence: 99%

Different resource allocation strategies result from selection for litter size at weaning in rabbit does

Savietto

Cervera

Ródenas

et al. 2014

Animal

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This study examined the effect of long-term selection of a maternal rabbit line, solely for a reproductive criterion, on the ability of female rabbits to deal with constrained environmental conditions. Female rabbits from generations 16 and 36 (n = 72 and 79, respectively) of a line founded and selected to increase litter size at weaning were compared simultaneously. Female rabbits were subjected to normal (NC), nutritional (NF) or heat (HC) challenging conditions from 1st to 3rd parturition. Animals in NC and NF were housed at normal room temperatures (18°C to 25°C) and respectively fed with control (11.6 MJ digestible energy (DE)/kg dry matter (DM), 126 g digestible protein (DP)/kg DM, and 168 g of ADF/kg DM) or low-energy fibrous diets (9.1 MJ DE/kg DM, 104 g DP/kg DM and 266 g ADF/kg DM), whereas those housed in HC were subjected to high room temperatures (25°C to 35°C) and the control diet. The litter size was lower for female rabbits housed in both NF and HC environments, but the extent and timing where this reduction took place differed between generations. In challenging conditions (NF and HC), the average reduction in the reproductive performance of female rabbits from generation 16, compared with NC, was −2.26 (P < 0.05) and −0.51 kits born alive at 2nd and 3rd parturition, respectively. However, under these challenging conditions, the reproductive performance of female rabbits from generation 36 was less affected at 2nd parturition (−1.25 kits born alive), but showed a greater reduction at the 3rd parturition (−3.53 kits born alive; P < 0.05) compared with NC. The results also showed differences between generations in digestible energy intake, milk yield and accretion, and use of body reserves throughout lactation in NC, HC and NF, which together indicate that there were different resource allocation strategies in the animals from the different generations. Selection to increase litter size at weaning led to increased reproductive robustness at the onset of an environmental constraint, but failure to sustain the reproductive liability when the challenge was maintained in the long term. This response could be directly related to the shortterm environmental fluctuations (less severe) that frequently occur in the environment where this line has been selected.

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“…Thyroid hormones (THs: -tri-iodothyronine, T 3 ; -tetra-iodothyronine, thyroxine, T 4 ) play central roles in the control of growth, development and metabolism (Oppenheimer et al 1987, Dauncey 1990, Chin & Yen 1997 and they are essential for normal development and function of striated muscle (Muscat et al 1995). Coincident with a perinatal increase in circulating TH levels, embryonic and neonatal myosin heavy chain (MyHC) isoforms are repressed and adult MyHC isoforms are accumulated, and there are also marked muscle-specific changes in cellular metabolism and mitochondrial biogenesis (d 'Albis & Butler-Browne 1993, Herpin et al 1996.…”

Section: Introductionmentioning

confidence: 99%

Differential expression of thyroid hormone receptor isoforms is strikingly related to cardiac and skeletal muscle phenotype during postnatal development

White¹,

Dauncey²

1999

Journal of Molecular Endocrinology

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The genomic actions of thyroid hormones (THs) are mediated by receptors (TRs) that are encoded by two protooncogenes, c-erbA-and c-erbA-. The precise functions of the TR isoforms are unclear and this study focuses on the potential roles of the TR and TR isoforms in mammalian striated muscles postnatally. The porcine TR 1, TR 2 and TR 1 cDNAs were first cloned, sequenced and characterised by Northern blotting. A quantitative analysis of TR isoform expression was then undertaken, using RNase protection analysis with novel riboprobes designed to detect relative expression levels of TR 1, TR 2, TR 1 and TR 2, in functionally distinct muscles from 7-week-old pigs kept under controlled conditions of nutrition and thermal environment. We found a striking musclespecific pattern of TR isoform distribution: in heart the mRNA level of TR 2 (non-TH binding) was markedly greater (P<0·01) than that of TR 1 (TH binding); in longissimus dorsi the opposite pattern of expression occurred (TR 1>TR 2, P<0·001); in soleus, diaphragm and rhomboideus there were no differences between the two isoforms. The overall abundance of TR was very much lower than that of TR , and TR 1 was expressed at a higher level than TR 2 in all muscles. Together with recent data from TR gene inactivation studies and the established role of TH in determining myosin heavy chain isoform expression and muscle phenotype, these results suggest a role for differential expression of TR isoforms in acquisition and maintenance of optimal cardiac and skeletal muscle function.

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Thyroid hormones and thermogenesis

Cited by 86 publications

References 73 publications

Effects of high temperature on body temperature and hormonal adjustments in piglets

Effects of high temperature on body temperature and hormonal adjustments in piglets

Different resource allocation strategies result from selection for litter size at weaning in rabbit does

Differential expression of thyroid hormone receptor isoforms is strikingly related to cardiac and skeletal muscle phenotype during postnatal development

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