Thyroid hormone status in protein energy malnutrition in Indian children

Abrol, Pankaj; Verma, Ashok; Hooda, H. S.

doi:10.1007/bf02864867

Cited by 9 publications

(9 citation statements)

References 8 publications

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“…Studies conducted by Abrol P et al , Turkey et al and Das BK et al, also showed similar results. 17,18,21 In contrast to present study, study conducted by Orbak Z et al, found that mean TSH levels of children with PEM were higher as compared to controls, study conducted by Kumar S et al, found that mean TSH levels showed a positive increase with increase in severity of PEM with maximum increase been observed in grade III PEM (One-way ANOVA; p= 0.015). 19,20 Normal TSH levels in children with PEM is possibly due to T 4 undergoing intracellular monodeiodination to form T 3 at pituitary level causing negative feedback inhibition of secretion of TSH, central unresponsiveness to low T 3 levels due to low intracellular receptor capacity.…”

Section: Discussioncontrasting

confidence: 89%

“…Studies conducted by Abrol P et al and Turkey et al have showed similar results ( Table 6, Table 7). 17,18 Similar results are reported by study done by Kumar S et al, Orbak Z et al and study conducted by Das BK et al, found that mean T 3 levels was significantly lower in malnourished children as compared to controls, however in their study they found no significant difference in mean T 4 levels of cases and controls. [19][20][21] Low T 3 levels in children with PEM is probably due to low binding proteins, impaired thyroxine monodeiodination in liver which leads to decreased peripheral conversion of T 4 to T 3 and elevated corticosteroids which is often seen in children with malnutrition (acts by inhibiting 5' deiodinase system) and low T 4 levels in children with PEM can be due to fall in thyroid secretion rate, depletion of reserves and failure of the adaptive mechanism.…”

Section: Discussionsupporting

confidence: 77%

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Thyroid hormone status in children with protein energy malnutrition

Sandeep

Krishnamurthy

2016

Int J Contemp Pediatr

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Section: Discussioncontrasting

confidence: 89%

Section: Discussionsupporting

confidence: 77%

Thyroid hormone status in children with protein energy malnutrition

Sandeep

Krishnamurthy

2016

Int J Contemp Pediatr

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“…The levels decreases as the severity of malnutrition increases and the difference between the TSH levels among cases with moderate and severe malnutrition was statistically significant (p <0.001). (16) The result disagreed with another result done by Abrol et al and Turkay et al, in their study found no significant difference in TSH when PEM children were compared to healthy controls (17) (18) The result disagreed with another result which finding confirmed that, TSH levels were similar in both groups (malnourished children and control group). (19) Also this result disagreed with another result which showed that, TSH levels were similar in PEM cases when compared to controls.…”

Section: Male 50%mentioning

confidence: 82%

Evaluation of Thyroid-stimulating hormone in Sudanese children patients with malnutrition

Abubaker¹,

Mohammed²,

Salih³

2018

IJASTR

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BackgroundMalnutrition is defined as a state of nutrition in which a deficiency or imbalance of energy, protein and other nutrients causes measurable adverse effects on tissue, body form (body shape, size and composition) and function. Objective This study was carried out to measure serum levels of Thyroid stimulating hormone in malnutrition children. Materials and Methods:A total of one hundred and twenty subjects were enrolled in this study, divided into three group (thirty of them, moderately malnourished (BMI < 15) , and thirty well nourished (BMI > 18) ) and thirty normal children as control , were collected from period between May to June 2017, chosen randomly from Mohammed AL Amin Hamid Hospital for Pediatric in Khartoum State (Sudan) , to assess Serum thyroid stimulating hormone in Sudanese children patients with malnutrition. Serum thyroid stimulating hormone was measured by using Enzyme Immune Sorbent Assay (ELISA) and results were analyzed using statistical of package social science (SPSS), computer program. ResultsThe study showed that, Children with malnutrition had significantly high level in mean serum thyroid stimulating hormone in moderately malnourished compared to control group(6.91±.97 versus 1.90±1.01 , P value =0.000) and there was significant increase in mean level of TSH hormone in well nourished compared to control group. (2.95 ± 1.38 versus1.90± 1.01, P value =0.001). Also the result showed, there was insignificant different in the mean of serum TSH in males compared to females children patients. Moderately malnourished (6.72 ±0.94) (7.09±0.99) , well nourished (2.95 ±1.46) (2.95±1.34) , with P value (0.990) (0.298) respectively. There was significantly decrease in BMI in patients compared to control group. (Mean ± SD: 15.28 ± 2.28 kg/m2 versus 19.25 ± 2.48 kg/m2). In this study 50% of patient were males and 50% of patients were females. The result showed 28% of patients at age 7 years, 23% of patients at age 6 years, 19% of patients at 5years, 11% of patients at 3 years and 3% of patients at 2 years. Conclusion In conclusion: Children with malnutrition had significantly high levels in means serum thyroid stimulating hormone (TSH) compared to control group.

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“…14 Abrol P et al, Mean T3, T4 and TSH levels in PEM group was 107.7, 8.3 and 2.6 respectively, which were higher than the mean values of the present study. 6 This could be substantiated by the fact that severity of malnutrition is higher in Madhya Pradesh in comparison to other Indian states.…”

Section: Discussionmentioning

confidence: 99%

Study of thyroid profile in malnourished children (6 months - 5 years) admitted in the nutritional rehabilitation centre and paediatric ward NSCB Medical College Jabalpur, India

Lazarus¹,

Kashyap²,

Borkar³

et al. 2018

Int J Contemp Pediatr

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Background: Globally, PEM continues to be a major health problem in developing countries and the most important risk factor for illnesses and death especially among young children. The research was conducted to study the effect of thyroid profile in malnourished children (6 month-5 years) admitted in tertiary care center in Central India.Methods: A cross sectional hospital based observational study was carried out in tertiary care hospital NSCB MCH Jabalpur. 80 malnourished children were included in the study. The cases were categorized into moderate and severe malnutrition as per WHO classification. Detailed clinical assessment of nutritional status followed by anthropometric measurement (weight for height) was recorded in predesigned proforma. Triiodothyronine (T3), Thyroxine (T4), thyroid stimulating hormone (TSH), serum total protein and serum albumin were estimated. The parameters were compared among SAM and MAM groups using appropriate tool.Results: Mean serum protein, serum albumin, T3, T4 were significantly low in SAM group, when compared to the MAM group (p <0.001). while level of TSH was not found significant among SAM and MAM groups.Conclusions: Malnutrition is associated with decrease level of thyroid hormone levels and were positively correlated with serum total protein and albumin levels. The decrease level of thyroid hormone may have a contributory role in retarded growth and development.

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Thyroid hormone status in protein energy malnutrition in Indian children

Cited by 9 publications

References 8 publications

Thyroid hormone status in children with protein energy malnutrition

Thyroid hormone status in children with protein energy malnutrition

Evaluation of Thyroid-stimulating hormone in Sudanese children patients with malnutrition

Study of thyroid profile in malnourished children (6 months - 5 years) admitted in the nutritional rehabilitation centre and paediatric ward NSCB Medical College Jabalpur, India

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