Study of thyroid profile in malnourished children (6 months - 5 years) admitted in the nutritional rehabilitation centre and paediatric ward NSCB Medical College Jabalpur, India

Lazarus, Monica; Kashyap, Alok Kumar; Borkar, Rahul; Ajmariya, Manish

doi:10.18203/2349-3291.ijcp20181545

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…7 The previous study showed that malnutrition affected the thyroid function in children as malnutrition children have lower thyroid serum levels. 12 Malnutrition is one of the main manifestations of TB, which may explain the abnormalities of thyroid function in TB. In malnutrition, as an adaptive response, the thyroid structure changes, which causes disturbance in thyroid gland function, resulting in reduced thyroid hormone in circulation.…”

Section: Discussionmentioning

confidence: 99%

Thyroid Profile of Childhood Tuberculosis Treated with Anti Tuberculosis Drug During Intensive Phase

Anam

Mahmudah

Cayami

et al. 2022

J. Biomed. Transl. Res.

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Background: Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. The incidence is 10 % in children. Tuberculosis has high morbidity and mortality which needs adequate treatment. The side effects of FDC is thyroid hormone dysfunction which can interfere children's quality of life. However, research about the effect of FDC therapy on thyroid hormone profile in children with TB are very limited. Objective: To determine the effect of anti-tuberculosis drug treatment on thyroid hormone profile in paediatric tuberculosis. Methods: A one group pretest-posttest design study of 50 patients was conducted at the Semarang Health Center for the period January 2021-June 2021. Thyroid function tests of TSH, FT4 and T3, in TB children were measured before FDC therapy and 2 months after administration. The data were analysed descriptively and a comparative test was performed using SPSS 25.Results: There were no significant differences in TSH, FT4 and T3 serum levels before FDC therapy and 2 months of FDC administration. Thyroid hormone levels before treatment and 2 months after administration of FDC, respectively, euthyroid in 44 vs 42 patients.Conclusion: Two months of tuberculosis treatment in children decreased the serum FT4 and T3 level but no changes in the serum TSH level before and after the treatment.

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Section: Discussionmentioning

confidence: 99%

Thyroid Profile of Childhood Tuberculosis Treated with Anti Tuberculosis Drug During Intensive Phase

Anam

Mahmudah

Cayami

et al. 2022

J. Biomed. Transl. Res.

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“…Our results was comparable with the study conducted by Lazarus M et al, which report the mean value of T3, T4 and TSH were 99.3ng/dl, 6.0ug/dl and 2.0 mIU/I respectively. 13 We estimate that majority of patients (47.…”

Section: Operational Definitionsmentioning

confidence: 99%

Screening for Hypothyroidism in children with severe acute malnutrition at Nutrition Rehabilitation Center, Children’s Hospital and Institute of Child Health Multan.

Khan

Fayyaz

et al. 2021

TPMJ

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Objective: To determine the percentage of Hypothyroidism in children with severe acute malnutrition. Study Design: Cross Sectional study. Setting: Nutrition Rehabilitation Center, Children’s Hospital and Institute of Child Health Multan. Period: January 2019 to December 2019. Material & Methods: A total of 255 malnourished patients (as per inclusion criteria) were included in current study. A written Performa was designed to collect history, anthropometric measurements and systemic examination. Taking aseptic measures venous blood was sent for baseline tests as well as for T3, T4 and TSH, total serum protein albumin and total ferritin levels to hospital laboratory. Correlation between serum thyroid concentrations and total protein, albumin, hemoglobin and serum ferritin were estimated by using t-test and p-vlaue less than 0.05 was considered as significant. Total collected data was entered and analyzed in SPSS version 21.0. Results: A total of 255 malnourished children were included in this study. Majority of studied subjects were male (52.5%) with 83.92%, 3-5 years of age. Amongst the 255 children mean values of T3 in MAM and SAM patients were 105.4 ng/dl and 89.7 ng/dl respectively. There was a statistically significant (p <0.001) association between decreased T3 and type of malnutrition. Similarly, mean values of T4 in MAM and SAM patients were 6.3 ug/dl and 5.7 ug/dl respectively that was statistically significant (p <0.05). Lower values of T4 were higher among SAM children in 1 to 3 years age group compared to respective MAM children with p value .0.05 and high T4 value in 3-5 years age group of MAM children were both statistically insignificant. Higher mean Values of TSH was found in SAM compared to MAM children both age groups. Conclusion: Severe acute malnutrition (SAM) is associated with reduction in T3 and T4 levels and higher levels of TSH in SAM children as compared to MAM. The altered thyroid hormone status in children with PEM is perhaps a protective phenomenon to limit protein catabolism and lower energy requirements.

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Haematological Parameters and Thyroid Profile in Severely Malnourished Children: A Cross Sectional Study

Dhakad¹,

Gogia²,

Tripathi³

2022

Global Journal for Research Analysis

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INTRODUCTION: ). SAM and India has the highest prevalence of severe acute malnutrition (SAM) anaemia have an interplay association, the latter being the commonest comorbid medical problem. But now literature suggests that SAM is also associated with marked changes in secretion and metabolism of thyroid hormone as well as in the structure. METHOD AND MATERIAL: A cross-sectional study was conducted in 60 children between the age group of 6 months to 5 years fullling the criteria of SAM over a period of 2 months admitted at NRC, ABVGMC and District Hospital Vidisha. Detailed history of the child was obtained; complications were noted and managed accordingly. Blood sample was collected and was subjected to complete blood count, peripheral smear examination and thyroid prole. RESULTS: Out of 60 children of SAM, 11.67% had leukocytopenia and the same percent of children had leukocytosis. Thrombocytopenia was reported in 13.34% of the children and thrombocytosis was seen in 15%. TSH levels in children of age 6 month to 1 year of study population were in the normal range. Children of age 1 year to 5 years had values above normal in 7.31% and below normal in 2.43%. CONCLUSION: Megaloblastic anemia and dimorphic anemia along with high TSH level are prevalent in children with SAM along with iron deciency anemia but more specic studies are required to associate hypothyroidism with malnutrition and low serum protein.

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Study of thyroid profile in malnourished children (6 months - 5 years) admitted in the nutritional rehabilitation centre and paediatric ward NSCB Medical College Jabalpur, India

Cited by 3 publications

References 8 publications

Thyroid Profile of Childhood Tuberculosis Treated with Anti Tuberculosis Drug During Intensive Phase

Thyroid Profile of Childhood Tuberculosis Treated with Anti Tuberculosis Drug During Intensive Phase

Screening for Hypothyroidism in children with severe acute malnutrition at Nutrition Rehabilitation Center, Children’s Hospital and Institute of Child Health Multan.

Haematological Parameters and Thyroid Profile in Severely Malnourished Children: A Cross Sectional Study

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