Thyroid Hormone Role and Economy in the Developing Testis

Hernández, Arturo

doi:10.1016/bs.vh.2017.06.005

Cited by 27 publications

(21 citation statements)

References 141 publications

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“…In the early 21st century, T3 was revealed to regulate the growth and maturation of the testis of mammals, including influencing the proliferation and differentiation of Sertoli cells and Leydig cells (Holsberger et al, 2005;Mendis-Handagama and Siril Ariyaratne, 2005). T3 also participates in the steroidogenesis (e.g., the synthesis of T and E2) (Maran et al, 2000;Fallah-Rad et al, 2001;Hernandez, 2018). For a long time, T3 is mainly recognized to function during early testis development at prepubertal age.…”

Section: Discussionmentioning

confidence: 99%

A Deep Insight of Spermatogenesis and Hormone Levels of Aqua-Cultured Turbot (Scophthalmus maximus)

Liu

et al. 2021

Front. Mar. Sci.

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Turbot (Scophthalmus maximus) is an important marine fish both in Europe and North China. Although there are plenty of studies on the reproduction of turbot, the complete cytological process of spermatogenesis remains unclear. In this study, we investigated the submicroscopic structure of total 23 types of male germ cells throughout the breeding season, with a relatively complete process of the primary spermatocytes. We found that the spermatid tail formed early at Spermatid II, and there were at least 16 spherical mitochondria in the spermatozoa. The hepatosomatic index (HSI) and gonadosomatic index (GSI) both peaked during the breeding season. Preliminary analysis showed that the vitality of mature sperm was negatively correlated with the proportion of sperm deformity. The serum 3,5,3′-triiodothyronine (T3), 5-hydroxytryptamine (5-HT), testosterone (T), 17α,20β-Dihydroxy-4-pregnen-3-one (17α,20β-DHP), and 17β-estradiol (E2) all increased during the maturity period, with the change of T content most noticeable. Whereas in the testis, an overall high level of 11-ketotestosterone (11-KT) was more remarkable. The expression and localization of androgen receptor (AR) mRNA showed that the AR was highly expressed at the stages of II (15 – 70 g), with a slight rebound at the mature stages [IV(2200 g) to V(2500 g)], whose change was ahead to the changes of T and 11-KT. Fluorescence in situ hybridization (FISH) analysis showed that the AR mainly distributed in but not limited to Sertoli cells. This study represents the most complete overview of the reproductive cycle and spermatogenesis of turbot, which provides an important reference for the reproduction research and the guidance of flatfish breeding.

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Section: Discussionmentioning

confidence: 99%

A Deep Insight of Spermatogenesis and Hormone Levels of Aqua-Cultured Turbot (Scophthalmus maximus)

Liu

et al. 2021

Front. Mar. Sci.

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“…Among these biological processes, hormone and metabolic processes play an important role in spermatogenesis. Thyroid abnormalities (hyperthyroidism or hypothyroidism) can affect testicle size and the proliferation and differentiation of testicular cells such as Sertoli, Leydig, and germ cells, thereby affecting spermatogenesis and fertility (Wajner et al 2009;La Vignera et al 2017;Hernandez 2018). In fact, oligozoospermia and teratozoospermia are often observed in patients with thyroid abnormalities (Abalovich et al 1999; La Vignera and Vita Figure 4.…”

Section: Discussionmentioning

confidence: 99%

Comparison of proteomic profiles from the testicular tissue of males with impaired and normal spermatogenesis

Liang

Zheng

Zeng

et al. 2020

Systems Biology in Reproductive Medicine

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“…Developmental hypothyroidism also leads to consistent abnormalities in testis development and the hormonal pathophysiology of the gonadal axis (Hernandez 2018b). The occurrence and severity of these abnormalities may vary depending on the degree and length of the hypothyroidism and the stage of development affected (from early neonatal to pubertal age).…”

Section: Hypothyroidismmentioning

confidence: 99%

“…In this context of testis development and intergenerational transmission of epigenetic information, thyroid hormones (TH) have pleiotropic effects in mammalian systems, and the developing testis is also a critical target organ (Hernandez 2018b). Alterations in TH status and signaling have profound effects on multiple cellular processes and functions of the testis, especially during development, ultimately impacting male fertility.…”

Section: Introductionmentioning

confidence: 99%

Thyroid hormone action in the developing testis: intergenerational epigenetics

Hernández

Martı́nez

2020

Journal of Endocrinology

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Male fertility involves the successful transmission of the genetic code to the next generation. It requires appropriately timed cellular processes during testis development, adequate support of spermatogenesis by hormonal cues from the reproductive axis and cellular cross-talk between germ and somatic cells. In addition to being the vessel of the father’s genome, increasing evidence shows that the mature sperm carries valuable epigenetic information – the epigenome – that, after fecundation, influences the development of the next generation, affecting biological traits and disease susceptibility. The epigenome of the germ line is susceptible to environmental factors, including exogenous chemicals and diet, but it is also affected by endogenous molecules and pathophysiological conditions. Factors affecting testis development and the epigenetic information of the germ line are critical for fertility and of relevance to the non-genetic but heritable component in the etiology of complex conditions. Thyroid hormones are one of those factors and their action, when untimely, produces profound effects on the developing testis, affecting spermatogenesis, steroidogenesis, testis size, reproductive hormones and fertility. Altered thyroid hormone states can also change the epigenetic information of the male germ line, with phenotypic consequences for future generations. In the context of past literature concerning the consequences of altered thyroid hormone action for testis development, here we review recent findings about the pathophysiological roles of the principal determinants of testicular thyroid hormone action. We also discuss limited work on the effects of thyroid hormone on the male germ line epigenome and the implications for the intergenerational transmission of phenotypes via epigenetic mechanisms.

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Thyroid Hormone Role and Economy in the Developing Testis

Cited by 27 publications

References 141 publications

A Deep Insight of Spermatogenesis and Hormone Levels of Aqua-Cultured Turbot (Scophthalmus maximus)

A Deep Insight of Spermatogenesis and Hormone Levels of Aqua-Cultured Turbot (Scophthalmus maximus)

Comparison of proteomic profiles from the testicular tissue of males with impaired and normal spermatogenesis

Thyroid hormone action in the developing testis: intergenerational epigenetics

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