Thyroid hormone regulates the obesity gene <i>tub</i>

Koritschoner, Nicolás P.; Álvarez‐Dolado, Manuel; Kurz, Steffen M; Heikenwälder, Mathias; Hacker, Christine; Vogel, Frank; Múñoz, Alberto; Zenke, Martin

doi:10.1093/embo-reports/kve107

Cited by 49 publications

(27 citation statements)

References 31 publications

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“…It is known that TH can stimulate the expression and activate a number of proteins that are candidates for regulating insulin sensitivity [30,31] . A functional TH response element in the promoter region of the GLUT4 gene, which contributes to impaired insulin-stimulated glucose disposal, has been described and characterized [15] .…”

Section: Discussionmentioning

confidence: 99%

Relationship between Thyroid-Stimulating Hormone and Insulin in Euthyroid Obese Men

et al. 2008

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Background/Aims: Obesity has been associated with hypothyroidism and impaired insulin sensitivity. However, few studies have specifically addressed the association between insulin sensitivity and thyroid function. Our aim was to look for a relation between these 2 factors in a sample of obese males. Methods: One hundred and forty-four euthyroid male obese patients – mean age 42.6 years, mean body mass index (BMI) 41.8 – were enrolled in this cross-sectional study. The hospital study protocol at entrance included baseline serum thyroid-stimulating hormone (TSH), insulin and glucose concentrations. Data were studied using an age-adjusted simple and multivariate linear regression analysis with TSH as the dependent and insulin and BMI as the independent variables. Results: Mean TSH and insulin were 1.6 and 21.2 mU/l, respectively. It was found that their relationship follows a regression model: TSH = 1.725–0.019 (age) + 0.003 (insulin) + 0.017 (BMI). Further data showed a positive correlation between BMI and TSH (r = 0.22; p < 0.05), as well as between serum baseline insulin (>10 mU/l) and TSH concentration (r = 0.27; p < 0.05). This association was stronger in patients with higher insulin values (>21.2 mU/l; r = 0.40; p < 0.01). However, negative correlations between age and insulin (r = –0.14; not significant) and age and TSH (r = –0.35; p < 0.05) were observed. Conclusions: In obese males, insulin resistance is significantly related with impairment of thyroid function, and this situation seems to be attenuated with age.

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Section: Discussionmentioning

confidence: 99%

Relationship between Thyroid-Stimulating Hormone and Insulin in Euthyroid Obese Men

et al. 2008

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“…Indeed, it has been shown in obese diabetic rodents that use of thyroid hormone at non-or subthyrotoxic levels enhanced insulin sensitivity and reduced both hyperinsulinemia and hyperglycemia [9]. By contrast, deprivation of thyroid hormone in animals or genetic mutation of deiodinase, an important regulator of thyroid hormone metabolism, in humans induce an obesity and insulin resistance state [21,22]. In addition, thyroid hormones can also cooperate with catecholamines to enhance lipolysis, decrease visceral fat mass, and improve insulin resistance [23].…”

Section: Discussionmentioning

confidence: 99%

Lower serum free thyroxine levels are associated with metabolic syndrome in a Chinese population

et al. 2005

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“…Experiments on animals have shown a correlation between thyroid hormones and changes in weight. 1 Studies on thyroid hormones in obese adults are inconsistent. [2][3][4] There has been discussion as to whether leptin influences the production of thyroid hormones.…”

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Thyroid hormones before and after weight loss in obesity

Reinehr

2002

Archives of Disease in Childhood

161

181

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Background: Little is known about changes in thyroid function in obese children. An influence of leptin on thyroid hormone synthesis has been proposed. Aims: To examine thyroid function and leptin concentrations in obese children. Methods: Triiodothyronine (T3), thyroxine (T4), thyroid stimulating hormone (TSH), and leptin were measured in 118 obese children (aged 4.5-16 years); thyroid function was also determined in 107 healthy children of normal weight. T3, T4, and TSH were analysed in 55 obese children who had achieved weight reduction and in 13 obese children who had not achieved weight reduction after one year based on normal energy diet. Results: TSH, T3, and T4 were significantly higher in obese children compared to those of normal weight. Twelve per cent of the obese children had TSH, 15% had T3, and 11% had T4 concentrations above the twofold standard deviation of normal weight children. The degree of overweight correlated with T3, T4, and TSH. Thyroid hormones did not correlate significantly with leptin. A reduction in overweight showed a significant decrease in T3, T4, and leptin serum concentrations, but there was no significant change in TSH. Conclusion: Peripheral thyroid hormones (T3, T4) and TSH are moderately increased in obese children; weight reduction leads to a long term decrease in the peripheral thyroid hormones but not in TSH. There is no necessity to treat the increased serum TSH.

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Thyroid hormone regulates the obesity gene tub

Cited by 49 publications

References 31 publications

Relationship between Thyroid-Stimulating Hormone and Insulin in Euthyroid Obese Men

Relationship between Thyroid-Stimulating Hormone and Insulin in Euthyroid Obese Men

Lower serum free thyroxine levels are associated with metabolic syndrome in a Chinese population

Thyroid hormones before and after weight loss in obesity

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