Thyroid hormonal changes among women with polycystic ovarian syndrome in Baghdad – a case-control study

Moustafa, Mayada M.; Jamal, Mohammed Y.; Al-Janabi, Rawaa Dawood

doi:10.12688/f1000research.18572.1

Cited by 5 publications

(4 citation statements)

References 13 publications

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“…The BMI of the PCOS hypothyroid women shows significantly higher values when compared to control groups with (P = 0.013). These results are similar to the others results 7,12] Over weight and obesity are commonly observed in both PCOS and hypothyroidism, so there was a significant increase in the BMI in PCOS and hypothyroid groups 13 .…”

Section: Discussionsupporting

confidence: 92%

“…The PCOS euthyroid group values were within the normal range but significantly higher than the control group where the p value was 0.001 and the PCOS hypothyroid group was very high compared to the control and the PCOS euthyroid groups. Many studies have been done to find out the association between the TSH and PCOS, but few studies reported an association between the control and PCOS groups as the TSH values were significantly higher in PCOS group compared to control groups 8,12,13 .…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of thyroid function status in polycystic ovary syndrome

Shareefa¹

2020

MIJOPHY

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Background: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy seen in reproductive age women. Recent literature suggests an increase in the incidence of thyroid disorders in females with polycystic ovary syndrome. The aim of this study is to evaluate the occurrence of thyroid dysfunction in subjects with polycystic ovarian syndrome as compared to controls of same age group. The study was a case control study conducted on 90 women, in whom 60 women were diagnosed with PCOS euthyroid and PCOS hypothyroid each and 30 normal healthy women with regular menstrual cycles as the control group within the age group of 20 to 40 years. The study was conducted at the department of Physiology, Kakatiya medical college, Warangal. The study revealed that the thyroid dysfunction was observed in the PCOS groups when compared to the control group. The PCOS hypothyroid women had significantly increased levels of TSH levels when compared to the PCOS euthyroid and control women. The T3 levels were significantly reduced in the PCOS hypothyroid women when compared to PCOS euthyroid and control groups. T4 levels were similar in all the groups. The FSH levels did not show any significant difference between the PCOS euthyroid and PCOS hypothyroid groups, but LH levels showed statistically significant difference between the PCOS euthyroid and PCOS hypothyroid groups. There was an association between the PCOS and the thyroid dysfunction as the TSH levels of the PCOS euthyroid were significantly higher than the control groups and very high in the PCOS hypothyroid groups.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Evaluation of thyroid function status in polycystic ovary syndrome

Shareefa¹

2020

MIJOPHY

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“…showed a significantly higher prevalence of autoimmune thyroiditis and goiter in PCOS patients than that in control subjects [26]. In another study, 20 (40%) of 50 patients with PCOS showed subclinical hyperthyroidism [27]. In a study, Michalakis et al reported prevalence of SCH was 23% among patients seeking treatment for infertility [28].…”

Section: Discussionmentioning

confidence: 91%

Thyroid Disorders in Women with Polycystic Ovary Syndrome

Pervin¹,

Kazal²,

Rahman³

et al. 2020

JBM

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Background: Polycystic ovary syndrome (PCOS) is one of the common endocrinopathies of women in the reproductive age group. Thyroid hormones have various effects on the reproductive system of female. PCOS and thyroid dysfunction are linked to each other since several years. Objective: To evaluate and detect the thyroid dysfunction in patients with PCOS attending in a tertiary care hospital in Bangladesh. Methodology: This was a prospective cross sectional study conducted from

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“…11 Moreover, most of the target population is teenagers and women of reproductive age, and they may be unavailable for transvaginal ultrasound evaluation because of their virginal status or obesity. 12 In addition to unclear diagnostic criteria, the presence of different phenotypes with PCOS further complicates the diagnosis. The technical advances in imaging have led to an artificial increase in PCOM resulting in confusion over its use as diagnostic criteria.…”

Section: Discussionmentioning

confidence: 99%

Role of anti mullerian hormone (AMH) in diagnosis of polycystic ovarian syndrome (PCOS) in Indian women

Gupta,

Pandey,

Jain

et al. 2023

IJOGR

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: Transvaginal ultrasound is an important part of the Rotterdam criteria, which are commonly used to diagnose polycystic ovary syndrome (PCOS). Specifically, the presence of polycystic ovarian morphology (PCOM) is a key factor in the criteria. Another useful indicator of PCOM is the Anti-Mullerian hormone (AMH) level.The objective is to evaluate the diagnostic accuracy of serum Anti-Mullerian hormone (AMH) in identifying polycystic ovary syndrome (PCOS) and determine whether it can be used as a substitute for polycystic ovarian morphology (PCOM) in the Rotterdam criteria. Additionally, we aim to investigate the relationship between AMH levels and hyperandrogenism in PCOS patients.A study was out in SSH BHU various parameters will be used in diagnosis. Serum AMH Radiology: By Transvaginal Sonography single observer obtained dimensions for ovarian volume and the maximum number of follicles in one section. AMH levels will be estimated using commercially available Gen-II ELISA assay. Biochemical evaluation will be done in the Department of Bio-Chemistry IMS BHU. The Anti-Mullerian hormone (AMH) serum levels will be measured using a commercially available ultra-sensitive Gen-II enzyme-linked immunosorbent assay (ELISA) kit from Beckman Coulter, CA. The ELISA has a lower limit of detectability (LoD) of 0.08 ng/ml, a lower limit of quantification (LoQ) of 0.17 mg/ml, and an intra-assay coefficient of variation of 5.8%. The unit of measurement is ng/mL (1ng/mL=7.14 pmol/L). The study showed that Anti-Mullerian hormone (AMH) levels were markedly higher in individuals with polycystic ovary syndrome (PCOS) than in controls. While AMH alone was not a reliable diagnostic marker for PCOS, the findings suggested that incorporating AMH levels as an additional factor in the existing Rotterdam criteria could improve the accuracy of PCOS diagnosis. Therefore, AMH levels have the potential as a useful adjunct marker for the diagnosis of PCOS.

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Thyroid hormonal changes among women with polycystic ovarian syndrome in Baghdad – a case-control study

Cited by 5 publications

References 13 publications

Evaluation of thyroid function status in polycystic ovary syndrome

Evaluation of thyroid function status in polycystic ovary syndrome

Thyroid Disorders in Women with Polycystic Ovary Syndrome

Role of anti mullerian hormone (AMH) in diagnosis of polycystic ovarian syndrome (PCOS) in Indian women

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