Thyroid hormonal activity of the flame retardants tetrabromobisphenol A and tetrachlorobisphenol A

Kawa, Shigeyuki; Jinno, Norimasa; Ohta, Shigeru; Kuroki, Hiroaki; Fujimoto, Nariaki

doi:10.1016/s0006-291x(02)00262-0

Cited by 299 publications

(180 citation statements)

References 23 publications

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“…LC 50 concentrations reported include 0.51 mg/l (0.9 M) in bluegill sunfish, 0.40 mg/l (0.7 M) in rainbow trout (WHO/IPCS 1995), and a relatively high 3 mg/l (5.5 M) in zebrafish (Lee et al 1993). Evidence for TBBPA toxicity at lower doses is limited and points to modulation of the thyroid and reproductive hormonal systems: TBBPA competes with the in vitro binding of thyroxin to its human plasma-transporter protein, transthyretin (Meerts et al 2000;Hamers et al 2004), and the rat thyroid receptor (Kitamura et al 2002), and increases the response to T3 in cultured GH3 rat pituitary adenoma cells (Kitamura et al 2005a). However, 10 −8 M (54 ng/l) TBBPA and higher may suppress T3-dependent tail shortening in Rana rugosa tadpoles, indicating anti-thyroid activity (Kitamura et al 2005b).…”

Section: Introductionmentioning

confidence: 99%

Toxicity of tetrabromobisphenol A (TBBPA) in zebrafish (Danio rerio) in a partial life-cycle test

et al. 2006

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Toxicological effects of the widely used flame retardant, tetrabromobisphenol A (TBBPA) were assessed in a partial life-cycle test with zebrafish (Danio rerio). Exposure of adult fish during 30 days to water-borne TBBPA in nominal concentrations ranging from 0 (control) to 1.5 M was followed by exposure of the offspring in early life stages up to 47 days posthatching (dph) to the same concentrations. Adults exposed to 3 and 6 M showed severe disorientation and lethargy shortly after beginning of exposure and were euthanized. Because semistatic exposure resulted in fluctuating water concentrations, pooled fish samples were chemically analyzed for internal dose assessment. Egg production was decreased in fish exposed to TBBPA concentrations of 0.047 M and higher, and a critical effect level of 7.2 g/g lipid with a lower 5% confidence limit of 3.9 g/g lipid for 50% decreased egg production was calculated. Histology of adult ovaries indicated a relative increase of premature oocytes in two surviving females exposed to 1.5 M. Hatching of TBBPA-exposed larvae was decreased except in animals exposed to 0.375 M. In the highest exposure concentration, early posthatching mortality was high (81%) in larvae and the surviving juveniles showed a significant predominance of the female phenotype. Exposure of eggs from control parents up to 6 M TBBPA resulted in increasing malformation and pericardial fluid accumulation from 1.5 M; at higher concentrations, all embryos failed to hatch. The presented results indicate decreased reproductive success in zebrafish at environmentally relevant TBBPA concentrations.

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Section: Introductionmentioning

confidence: 99%

Toxicity of tetrabromobisphenol A (TBBPA) in zebrafish (Danio rerio) in a partial life-cycle test

et al. 2006

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“…In contrast, some studies showed that TBBPA was estrogenic by means of estrogen receptor binding and growth stimulation in estrogen-dependent MCF-7 cells (Samuelsen et al, 2001) and MtT/E2 cells (Kitamura et al, 2002). In another study, Kitamura et al (2005) reported the observed anti-estrogenic activity against E2 for TBBPA in the MCF-7 reporter assay.…”

Section: Endocrine-disrupting Potency Of Tbbpa In Vitromentioning

confidence: 95%

“…Due to the structural resemblance to thyroid hormones (i.e. thyroxine), TBBPA has been shown to disrupt thyroid hormone function by binding to transthyretin and thyroid hormone receptors (Kitamura et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

“…TBBPA has also been reported to exhibit some estrogen-like properties in vitro (Samuelsen et al, 2001;Kitamura et al, 2002). However, its potencies in the MCF-7 human breast cancer cell line were not as great as those of TrBBPA, DBBPA, MBBPA, or BPA (Samuelsen et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

“…But the structural similarity of TBBPA to bisphenol A, a known weak environmental estrogen, suggests that this compound may have the ability to bind to the estrogen receptor and disrupt the signaling process of the endocrine system (Birnbaum and Staskal, 2004). It has been reported that TBBPA can induce estrogen-like properties (Samuelsen et al, 2001;Kitamura et al, 2002). Due to the contradicting results in the literature, it is clear that further research is required to address the effects posed by TBBPA.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Hormonal effects of tetrabromobisphenol A using a combination of in vitro and in vivo assays

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Ying

Liang

et al. 2013

Comparative Biochemistry and Physiology Part C: Toxicology &

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Endocrine Disruption in Toxic Responses

Kawa

Sugihara

Nakamura

et al. 2009

General, Applied and Systems Toxicology

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Many endocrine‐disrupting agents, including industrial materials, pesticides, pharmaceuticals and phytochemicals, have been identified with their use by in vitro assay systems and in vivo studies in laboratory animals. These chemicals are widely distributed in the environment, and are able to mimic or antagonize the biological functions of natural hormones. Indeed, abnormalities thought to be due to such agents have been found in animals throughout the world. There is also thought to be a risk to humans, for example, DES syndrome. Xenoestrogens can accumulate in our environment, and may play a role in the increasing incidences of breast cancer, testicular cancer and other problems of the reproductive system in humans. Risks due to endocrine disruptors in the environment are discussed in this chapter.

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Thyroid hormonal activity of the flame retardants tetrabromobisphenol A and tetrachlorobisphenol A

Cited by 299 publications

References 23 publications

Toxicity of tetrabromobisphenol A (TBBPA) in zebrafish (Danio rerio) in a partial life-cycle test

Toxicity of tetrabromobisphenol A (TBBPA) in zebrafish (Danio rerio) in a partial life-cycle test

Hormonal effects of tetrabromobisphenol A using a combination of in vitro and in vivo assays

Endocrine Disruption in Toxic Responses

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