Hormonal effects of tetrabromobisphenol A using a combination of in vitro and in vivo assays

Effects of steroid hormones on reproduction- and detoxification-related gene expression in adult male mosquitofish, Gambusia affinis

“…Sexually mature male mosquitofish, Gambusia affinis, were obtained in December 2009 from the Liuxi River, which is located at nearby Conghua town in Guangzhou city (southern China) and protected from pollution (Huang et al, 2013). Fish were transported back to the laboratory and kept indoor in circulating fresh water tanks at a constant temperature (24 ± 1°C) with a 12 h:12 h light/dark photoperiod.…”

“…By contrast, Vtg genes are generally silent in male fish and poorly expressed in juvenile fish, but they may be induced in juvenile and male fish including mosquitofish in response to E2 or other estrogenic compounds (Del Giudice et al, 2011;Xuereb et al, 2011;Huang et al, 2013). Indeed, induction of Vtg synthesis in males and juveniles is a well-known biomarker for estrogenic exposure (Henry et al, 2009;Xuereb et al, 2011).…”

“…Mosquitofish are sexually dimorphic and small fish species with a short generation time (Huang et al, 2013). The induction of secondary sex characteristics such as development of male-like gonopodium, and altered reproductive behavior in mosquitofish has been utilized widely for environmental toxicity studies (Xie et al, 2010;Kamata et al, 2011).…”

Ferrate(VI) oxidation of tetrabromobisphenol A in comparison with bisphenol A

“…w a t e r r e s e a r c h 6 2 ( 2 0 1 4 ) 2 1 1 e2 1 9 Huang et al, 2013). During Fe(VI) oxidation process, the determined androgenic and antiandrogenic activities decreased with increasing reaction time, and the reduction of the androgenic and antiandrogenic activities was in proportion to the decreasing residual TBBPA concentrations ( Fig.…”

iTRAQ-based quantitative proteomic analyses on the gender-specific responses in mussel Mytilus galloprovincialis to tetrabromobisphenol A

“…Szymanska et al (1999) reported the hepatotoxicity of TBBPA in rat liver, indicated by the significant changes of biochemical indicators including glutathione (GSH), malondialdehyde (MDA) and 5-aminolevulinate (ALA-D). In addition, the endocrine disrupting effects induced by TBBPA were also found in different models including mammalian and fish (Meerts et al, 2000;Huang et al, 2013). The tissue of hepatopancreas is an important digestive and immune organ in bivalve functioning as innate immunity and detoxification (Du et al, 2013).…”