Thyroid gland and radiation (Ukrainian-American Thyroid Project)

Тronko, М.D.; Bobylyova, Olga O.; Bogdanova, T; Epshtein, Ovsiy V.; Likhtaryov, Illya A.; Markov, Valentyn V.; Oliynyk, Valery A.; Tereshchenko, Valery P.; Shpak, Victor; Beebe, Gilbert W.; Bouville, André; Brill, A.B.; Burch, David; Fink, Daniel; Greenebaum, Ellen; Howe, Geoffrey R.; Luckyanov, Nickolas; Masnyk, Ihor J.; McConnell, Robert J.; Robbins, Jacob; Thomas, Terry L.; Voilleque, P.G.

doi:10.1016/s0531-5131(03)01216-0

Cited by 5 publications

(6 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[18][19][20] From 1998 through 2000, 13,243 participants underwent the first cycle of screening, which included examination by an endocrinologist, an ultrasound examination, determination of thyroid-stimulating hormone level, urinary iodine, and, if indicated, fine-needle aspiration (FNA) biopsy. 18,19 Ultrasound examinations using a 7.5-megahertz probe routinely targeted the thyroid gland and perithyroid regions, including the jugular (lateral) lymph nodes. FNA biopsy was undergone by all patients who had focal thyroid lesions that measured 10 mm in greatest dimension detected either on palpation or on ultrasound and by all patients who had sonographically suspicious lesions (based on hypoechogenicity, irregular shape/contour, microcalcifications, extension through thyroid capsule, interval growth, abnormal adenopathy) that measured from 5 mm to 10 mm in greatest dimension.…”

Section: Methodsmentioning

confidence: 99%

“…Members of the cohort under study had direct measurements of thyroid radioactivity in May to June 1986, allowing calculation of their individual thyroid doses of 131 I. [18][19][20] From 1998 through 2000, 13,243 participants underwent the first cycle of screening, which included examination by an endocrinologist, an ultrasound examination, determination of thyroid-stimulating hormone level, urinary iodine, and, if indicated, fine-needle aspiration (FNA) biopsy. 18,19 Ultrasound examinations using a 7.5-megahertz probe routinely targeted the thyroid gland and perithyroid regions, including the jugular (lateral) lymph nodes.…”

Section: Methodsmentioning

confidence: 99%

“…[18][19][20] Cohort members are examined at least every 2 years, and individuals who have nodules identified that are suspicious for cancer are sent to surgery. In this report, we provide a detailed characterization of the pathology of the thyroid cancers detected as a result of the first cycle of screening (from 1998 to 2000) and an analysis of their pathology related to tumor latency.…”

mentioning

confidence: 99%

“…The Ukrainian American Cohort Study was established to evaluate the risk of thyroid disorders in a welldefined group of individuals younger than age 18 years at the time of the accident and who had thyroid radioactivity measurements within the next few weeks. [18][19][20] Cohort members are examined at least every 2 years, and individuals who have nodules identified that are suspicious for cancer are sent to surgery. In this report, we provide a detailed characterization of the pathology of the thyroid cancers detected as a result of the first cycle of screening (from 1998 to 2000) and an analysis of their pathology related to tumor latency.…”

mentioning

confidence: 99%

See 3 more Smart Citations

A cohort study of thyroid cancer and other thyroid diseases after the Chornobyl accident

Bogdanova

Zurnadzhy

Greenebaum

et al. 2006

Cancer

Self Cite

View full text Add to dashboard Cite

BACKGROUND. The Ukrainian American Cohort Study evaluated the risk of thyroid disorders in a group of individuals who were younger than age 18 years at the time of the Chornobyl (Chernobyl) accident. In this article, the authors describe the pathology of thyroid carcinomas detected in the first screening. METHODS. From 1998 to 2000, 13,243 individuals completed the first cycle of screening examinations. Eighty patients underwent surgery between 1998 and 2004. Intraoperative and postoperative pathologic studies were performed at the Institute of Endocrinology and Metabolism, Kyiv. RESULTS. Pathologic analysis revealed 45 thyroid carcinomas, including 43 papillary thyroid carcinomas (PTCs) (95.6%) and 2 follicular thyroid carcinomas (FTCs) (4.4%). TNM classification (5th edition) of the PTCs included 8 T1 tumors (18.6%), 16 T2 tumors (37.2%), and 19 T4 tumors (44.2%). Fifteen PTCs (34.9%) were N1a,N1b, and 3 PTCs (7.0%) were M1. Among the PTCs, 8 exhibited the classical papillary histologic pattern (18.6%), 14 exhibited a follicular histologic pattern (32.6%), 5 exhibited a solid histologic pattern (11.6%), and 16 exhibited a mixed histologic pattern (37.2%). Both FTCs had a microfollicular‐solid structure. Eleven of 20 cohort members who underwent surgery before the first screening had PTCs. Regional metastases (63.6%) and distant metastases (18.2%) were more common in this group. CONCLUSIONS. Multifocal growth, lymphatic and blood vessel invasion, extrathyroid spread, and regional and distant metastases were more frequent in less differentiated PTCs (>30% solid structure). Small carcinomas (≤10 mm) comprised 23.3% of PTCs, and most of those (8 of 10 small carcinomas; 80%) were of the papillary‐follicular subtype and therefore were more differentiated. The solid subtype of PTC was associated with shorter latency, especially in individuals who were diagnosed before the first screening. The histology of post‐Chornobyl cancers is changing with time. Cancer 2006. Published 2006 by the American Cancer Society.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

A cohort study of thyroid cancer and other thyroid diseases after the Chornobyl accident

Bogdanova

Zurnadzhy

Greenebaum

et al. 2006

Cancer

Self Cite

View full text Add to dashboard Cite

show abstract

“…Mabuchi, Cardis, Preston, Ivanov, Okeanov, & Prisyazhniuk (1998) presented projections of substantial lifetime excess of thyroid cancer in inhabitants of the most contaminated regions that amounted to from 6 to 300 % depending on the average dose received. While realization of the dramatic scenario has been thoroughly studied and reported in those exposed as children (Cardis, Kesminiene, Ivanov, Malakhova, Shibata, Khrouch, et al, 2005;Kazakov, Demidchik, & Astakhova, 1992;Likhtarev, Kairo, Shpak, Tronko, & Bogdanova (1999) ;Tronko, Bobylyova, Bogdanova, Epstein, Likhtaryov, Markov, et al, 2003) only partial information on thyroid cancer in adults affected by the accident is available Ivanov, Tsyb, Ivanov, & Pokrovsky, 2004).…”

Section: Introductionmentioning

confidence: 99%

Thyroid Cancer in Ukrainian Population Groups Affected by the Chernobyl Accident

Prysyazhnyuk¹,

Romanenko²,

Gudzenko³

et al. 2009

Data Sci. J.

View full text Add to dashboard Cite

The study goal was to investigate thyroid cancer morbidity in population groups affected by the Chernobyl catastrophe. The study period comprised 1994-2006 for clean-up workers and 1990-2006 for Chernobyl evacuees and residents of contaminated territories. A significant increase of thyroid cancer incidence was registered in all observed population groups. The most significant excess over the national level was identified in clean-up workers. This amounted to a factor of 5.9, while it was 5.5 for the evacuees and 1.7 for the residents. The highest thyroid cancer risk was observed in persons exposed to radioiodine in childhood and adolescence.

show abstract

Screening effects in risk studies of thyroid cancer after the Chernobyl accident

Kaiser

Jacob

Blettner

et al. 2009

Radiat Environ Biophys

View full text Add to dashboard Cite

In this article scenarios have been developed, which simulate screening effects in ecological and cohort studies of thyroid cancer incidence among Ukrainians, whose thyroids have been exposed to (131)I in the aftermath of the Chernobyl accident. If possible, the scenarios were based on directly observed data, such as the population size, dose distributions and thyroid cancer cases. Two scenarios were considered where the screening effect on baseline cases is either equal to or larger than that of radiation-related thyroid cancer cases. For ecological studies in settlements with more than ten measurements of the (131)I activity in the human thyroid in May-June 1986, the screening bias appeared small (<19%) for all risk quantities. In the cohort studies, the excess absolute risk per dose was larger by a factor of 4 than in the general population. For an equal screening effect on baseline and radiation-related cancer (Scenario 1) the excess relative risk was about the same as in the general population. However, a differential screening effect (Scenario 2) produced a risk smaller by a factor of 2.5. A comparison with first results of the Ukrainian-US-American cohort study did not give any indication that a differential screening effect has a marked influence on the risk estimates. The differences in the risk estimates from ecological studies and cohort studies were explained by the different screening patterns in the general population and in the much smaller cohort. The present investigations are characterized by dose estimates for many settlements which are very weakly correlated with screening, the confounding variable. The results show that under these conditions ecological studies may provide risk estimates with an acceptable bias.

show abstract

Thyroid gland and radiation (Ukrainian-American Thyroid Project)

Cited by 5 publications

References 6 publications

A cohort study of thyroid cancer and other thyroid diseases after the Chornobyl accident

A cohort study of thyroid cancer and other thyroid diseases after the Chornobyl accident

Thyroid Cancer in Ukrainian Population Groups Affected by the Chernobyl Accident

Screening effects in risk studies of thyroid cancer after the Chernobyl accident

Contact Info

Product

Resources

About