Thyroid Function Tests in Preterm Infants Born to Preeclamptic Mothers with Placental Insufficiency

Belet, Nurşen; Imdat, Halit; Yanık, Filiz Bilgin; Küçüködük, Şükrü

doi:10.1515/jpem.2003.16.8.1131

Cited by 21 publications

(12 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…35 In this study, umbilical fT 4 levels in the neonates were lower than in the comparison group, a finding in concordance with literature. 13,14,17,22,26 This low umbilical fT 4 was not related to maternal fT 4 , therefore it is not likely to result from decreased maternal supply of fT 4 or impaired transfer. According to our data, these Because gestational age in the study group was 3 weeks older than in the comparison group, higher concentrations of TT 4 , fT 4 , TT 3 , and TBG were anticipated in the study group, explaining the higher TT 3 levels found.…”

Section: Discussionmentioning

confidence: 81%

“…18 -21 Free T 4 is generally found to be lower in umbilical cord samples from neonates born from preeclamptic pregnancies than in infants from normotensive pregnancies, but reports remain inconclusive. 13,14,17,[22][23][24][25][26] A low fT 4 can be a consequence of lower maternal thyroid hormone levels; however, it can also be caused by impaired transfer of T 4 due to placental insufficiency or fetal disease due to fetal growth restriction (FGR) and fetal acidosis.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Transient Hypothyroxinemia in Severe Hypertensive Disorders of Pregnancy

Buimer

Wassenaer²,

Ganzevoort³

et al. 2005

Obstetrics & Gynecology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 81%

mentioning

confidence: 99%

Transient Hypothyroxinemia in Severe Hypertensive Disorders of Pregnancy

Buimer

Wassenaer²,

Ganzevoort³

et al. 2005

Obstetrics & Gynecology

View full text Add to dashboard Cite

show abstract

“…We also observed an association between higher neonatal TSH levels in infants born to mothers with preeclampsia. Two studies found higher cord blood TSH in preterm neonates born to mothers with preeclampsia; however, other studies, some of which evaluated term infants, have not observed this finding (7, 12, 27, 28). Our findings, in combination with the other studies that found higher neonatal TSH levels in preterm infants born to mothers with preeclampsia, suggest that there may be placental insufficiency and/or fetal hypoxia which in turn triggers higher TSH levels in the neonate.…”

Section: Discussionmentioning

confidence: 95%

Maternal factors and complications of preterm birth associated with neonatal thyroid stimulating hormone

Ryckman

Spracklen

Dagle

et al. 2014

Journal of Pediatric Endocrinology and Metabolism

View full text Add to dashboard Cite

Thyroid hormones are important regulators of fetal neurodevelopment. Among preterm infants, TSH is highly variable. Understanding this variability will further improvements in screening for thyroid disorders in preterm infants. We examined 61 maternal and infant clinical and demographic factors for associations with neonatal TSH levels in 698 preterm neonates. TSH was measured as part of routine State-mandated newborn screening in Iowa. Of the maternal characteristics, nulliparous women (P=8x10−4), women with preeclampsia (P=2x10−3), and those with induced labor (P=3x10−3) had infants with higher TSH levels. TSH levels at the time of newborn screening were associated with respiratory distress syndrome (RDS) (P<0.0001) and sepsis (P=3x10−3). We replicated findings between parity and preeclampsia previously observed in primarily term infants. We also observed strong relationships between neonatal TSH and complications of prematurity including RDS and sepsis, which has implications for future studies examining this relationship both prenatally and longitudinally after birth.

show abstract

“…Placental insufficiency (PI) occurs when functional capacity of the placenta is limited or deteriorates, resulting in reduced transplacental transfer of oxygen and nutrients to the fetus (Gagnon 2003). Reduction or impairment of placental blood flow (Chaddha et al 2004), aberrant fibrin depositions or other thrombo-occlusive damage in the placenta (Chaddha et al 2004), and disruption of maternal-placental THs (Belet et al 2003) are all believed to contribute to PI pathogenesis in women. We provide evidence illustrating pathological and physiological features that are concordant with PI in our experimental mouse model.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Maternal, Embryo, and Placental Effects in CD-1 Mice following Gestational Exposure to Perfluorooctanoic Acid (PFOA) or Hexafluoropropylene Oxide Dimer Acid (HFPO-DA or GenX)

Blake

Cope

Hall

et al. 2020

Environ Health Perspect

162

113

View full text Add to dashboard Cite

BACKGROUND: Perfluorooctanoic acid (PFOA) is a poly-and perfluoroalkyl substance (PFAS) associated with adverse pregnancy outcomes in mice and humans, but little is known regarding one of its replacements, hexafluoropropylene oxide dimer acid (HFPO-DA, referred to here as GenX), both of which have been reported as contaminants in drinking water. OBJECTIVES: We compared the toxicity of PFOA and GenX in pregnant mice and their developing embryo-placenta units, with a specific focus on the placenta as a hypothesized target. METHODS: Pregnant CD-1 mice were exposed daily to PFOA (0, 1, or 5 mg=kg) or GenX (0, 2, or 10 mg=kg) via oral gavage from embryonic day (E) 1.5 to 11.5 or 17.5 to evaluate exposure effects on the dam and embryo-placenta unit. Gestational weight gain (GWG), maternal clinical chemistry, maternal liver histopathology, placental histopathology, embryo weight, placental weight, internal chemical dosimetry, and placental thyroid hormone levels were determined. RESULTS: Exposure to GenX or PFOA resulted in increased GWG, with increase in weight most prominent and of shortest latency with 10 mg=kg=d GenX exposure. Embryo weight was significantly lower after exposure to 5 mg=kg=d PFOA (9.4% decrease relative to controls). Effect sizes were similar for higher doses (5 mg=kg=d PFOA and 10 mg=kg=d GenX) and lower doses (1 mg=kg=d PFOA and 2 mg=kg=d GenX), including higher maternal liver weights, changes in liver histopathology, higher placental weights and embryo-placenta weight ratios, and greater incidence of placental abnormalities relative to controls. Histopathological features in placentas suggested that PFOA and GenX may exhibit divergent mechanisms of toxicity in the embryo-placenta unit, whereas PFOA-and GenX-exposed livers shared a similar constellation of adverse pathological features. CONCLUSIONS: Gestational exposure to GenX recapitulated many documented effects of PFOA in CD-1 mice, regardless of its much shorter reported half-life; however, adverse effects toward the placenta appear to have compound-specific signatures.

show abstract

Thyroid Function Tests in Preterm Infants Born to Preeclamptic Mothers with Placental Insufficiency

Cited by 21 publications

References 6 publications

Transient Hypothyroxinemia in Severe Hypertensive Disorders of Pregnancy

Transient Hypothyroxinemia in Severe Hypertensive Disorders of Pregnancy

Maternal factors and complications of preterm birth associated with neonatal thyroid stimulating hormone

Evaluation of Maternal, Embryo, and Placental Effects in CD-1 Mice following Gestational Exposure to Perfluorooctanoic Acid (PFOA) or Hexafluoropropylene Oxide Dimer Acid (HFPO-DA or GenX)

Contact Info

Product

Resources

About