Maternal factors and complications of preterm birth associated with neonatal thyroid stimulating hormone

Ryckman, Kelli K.; Spracklen, Cassandra N.; Dagle, John M.; Murray, Jeffrey C.

doi:10.1515/jpem-2013-0366

Cited by 31 publications

(44 citation statements)

References 29 publications

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“…We cannot rule out the potential for null findings in our analyses of TSH being masked by high variability of newborn TH levels shortly after birth. It may be that screening data from even more than 48 hr are required to observe differences, though the trend towards earlier hospital discharge makes this challenging to address in more recent years [Rose et al, ; Ryckman et al, ; Shapira et al, ; Williams et al, ]. Large differences in the TSH‐ASD association by stratification factors were not suggested here.…”

Section: Discussionmentioning

confidence: 76%

Neonatal thyroid hormone levels in association with autism spectrum disorder

et al. 2016

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Thyroid hormones (TH) are critical in early neurodevelopment, but few studies have examined whether neonatal TH levels influence risk of autism spectrum disorder (ASD). This study linked California neonatal screening data with live birth and Department of Developmental Services records to examine newborn TH levels in relation to ASD. Thyroxine (T4) and thyroid-stimulating hormone (TSH) levels were measured in newborn bloodspots as part of routine screening, in 1996 and 2002, respectively. Mean levels of T4 and TSH were compared between ASD cases and non-cases. Four hundred forty-seven thousand, fifty-nine screened, singleton births from 1996 and 446,424 from 2002 were examined, including 4,818 ASD cases. Binomial regression, using categories of T4 and TSH percentiles was used to calculate crude and adjusted risk ratios (RR). Covariates included maternal and child factors, gestational age, and age at blood draw. No significant associations were found with TSH levels and ASD in crude or adjusted analyses. ASD cases had significantly lower mean T4 levels than non-cases, but this association was no longer significant in adjusted analyses (RR in individuals in lowest 5th percentile of T4 levels = 1.13, 95% 0.93-1.37). However, this association appeared stronger in certain subgroup analyses, particularly among neonates with blood draw ≥48 hr from birth (RR = 1.67, 95% CI 1.08, 2.60), when TH levels become more stable. Thus, results from this large, population-based study did not suggest strong associations between neonatal TH and ASD, but certain subgroups of newborns with the lowest T4 levels may have modestly increased ASD risk. Autism Res 2016. © 2016 International Society for Autism Research, Wiley Periodicals, Inc. Autism Res 2017, 10: 585-592. © 2016 International Society for Autism Research, Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 76%

Neonatal thyroid hormone levels in association with autism spectrum disorder

et al. 2016

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“…This combination has expanded the novel application of linking newborn screening results to acquired newborn disease. (36, 37) Our study population included preterm infants from across the broad geographic and socioeconomic regions of California and the results remained robust while controlling for multiple patient demographic factors. In light of these strengths it should also be recognized that there are important limitations to the present study.…”

Section: Discussionmentioning

confidence: 81%

Acylcarnitine Profiles Reflect Metabolic Vulnerability for Necrotizing Enterocolitis in Newborns Born Premature

Sylvester

Kastenberg

Moss

et al. 2017

The Journal of Pediatrics

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Objectives Given the known risk factors for NEC, we hypothesized that metabolic dysfunction reflected in routinely collected newborn screening data would be associated with NEC in an at risk population. Study Design We conducted a retrospective cohort study using discharge records for all preterm neonatal intensive care unit admissions in California from 2005 to 2009. Infants with linked state newborn screening results were included. A model-development cohort of 94,110 preterm births from 2005 to 2008 was used to develop a risk-stratification model that was then applied to a validation cohort of 22,992 births from 2009. Results Fourteen acylcarnitines and acylcarnitine ratios were associated with increased risk of developing NEC. Each log unit increase in C5 and FC/(C16+18:1) was associated with a 78% and a 76% increased risk for developing NEC, respectively (OR 1.78, 95% CI 1.53 – 2.02, and OR 1.76, 95% CI 1.51 – 2.06). Six acylcarnitines, along with birth weight and total parenteral nutrition, were able to identify 89.8% of newborns with NEC in the model-development cohort (AUC=0.898, 95% confidence interval (CI) 0.889 – 0.907) and 90.8% of the newborns with NEC in the validation cohort (AUC=0.908, 95% CI 0.901 – 0.930). Conclusions These findings demonstrate that abnormal fatty acid metabolism is associated with prematurity and the development of NEC. Metabolic profiling through newborn screening may serve as an objective biologic surrogate of risk for the development of disease and thus facilitate disease prevention strategies.

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“…However, in 2013, Torkaman et al [8] reported the association with RDS while analyzing the TSH and free T 4 in premature infants, and in 2014, Ryckman et al [9] reported that there is a strong association between thyroid stimulating hormone and RDS. In addition, Tanaka et al [10] reported in 2007 that the TSH surge caused by the stress during birth improves surfactant production.…”

Section: Introductionmentioning

confidence: 99%

Association between Thyroid Stimulating Hormone and Respiratory Distress Syndrome of Newborn in the Preterm Infants

Kim

Kim³

2020

Preprint

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Abstract Background: Various hormones are known to influence the production and secretion of pulmonary surfactant. But the relationship between respiratory distress syndrome (RDS) and thyroid hormone has yet to be clarified. Methods: 126 infants with gestational age between 24 and 34 weeks who were hospitalized at the neonatal ICU of the Wonju Severance Christian Hospital from April 2017 to February 2019 were included in the study. Infants were divided into 3 groups by gestational age – 24 weeks 0 days to 28 weeks 0 days, 28 weeks 0 days to 31 weeks 0 days, and 31 weeks 0 days to 33 weeks 0 days, each with 18, 34, and 74 subjects, respectively. Among the subjects, there were 56 infants with RDS and 70 infants without RDS.Results: The group with lowest gestational age showed T3 and fT4 level that was lower than those of other groups (p<0.05) on the day of birth but there was no difference in the TSH level (p=0.129). T3 and TSH level were lower in the RDS group compared with the control group on the day of birth (p<0.05). Free thyroxine (fT4) level was higher in the control group on the day of birth but without any significant difference. Multiple logistic regression analysis showed that lower serum TSH levels on the day of birth was associated with a higher incidence of RDS (p<0.05).Conclusion: The incidence of RDS was significantly higher in infants with lower serum TSH levels at birth, but there was no significant difference in RDS incidence according to serum thyroid hormone levels.

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Maternal factors and complications of preterm birth associated with neonatal thyroid stimulating hormone

Cited by 31 publications

References 29 publications

Neonatal thyroid hormone levels in association with autism spectrum disorder

Neonatal thyroid hormone levels in association with autism spectrum disorder

Acylcarnitine Profiles Reflect Metabolic Vulnerability for Necrotizing Enterocolitis in Newborns Born Premature

Association between Thyroid Stimulating Hormone and Respiratory Distress Syndrome of Newborn in the Preterm Infants

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