Thyroid Function, Prevalent Coronary Heart Disease, and Severity of Coronary Atherosclerosis in Patients Undergoing Coronary Angiography

Abstract

This study investigated if free T4 and TSH concentrations or thyroid function categories were associated with prevalent CHD and the severity of coronary atherosclerosis in a population undergoing coronary angiography. This was a cross-sectional study including 1799 patients who were consecutively admitted and underwent coronary angiography. We evaluated the severity of coronary atherosclerosis using Gensini score. In the entire study population, free T4 level was inversely associated with prevalent CHD (OR = 0.95, 95% CI 0.91–0.99, P = 0.01) and the natural log-transformed Gensini score (ln(Gensini score)) (β = −0.03, 95% CI −0.05–−0.01, P = 0.005). The odds of CHD increased gradually across hyperthyroidism, subclinical hypothyroidism, and overt hypothyroidism groups using the euthyroid group as the reference, and the trend is borderline significant (P for trend = 0.051). When comparing to the euthyroid group, ln(Gensini score) of the overt hypothyroidism group was significantly higher (P = 0.009), but the trend was not significant (P for trend = 0.08). A significant association of thyroid function with CHD or ln(Gensini score) in euthyroid patients was not observed. The present study demonstrated an association of thyroid function with prevalent CHD and the severity of coronary atherosclerosis in a population undergoing coronary angiography. However, this association was not observed in euthyroid individuals.

Comparing Levels of Metabolic Predictors of Coronary Heart Disease between Healthy Lean and Overweight Females

“…The elevated level of 1-arachidonoyl-GPC (20:4n6), shown previously to be linked with increased CHD risk [ 15 ], was associated with increased cholesterol, alkaline phosphatase and T4, but lower homocysteine, LDL-cholesterol, total cholesterol and chloride. Elevated serum alkaline phosphatase and T4 were shown previously to be associated with the risk of CHD [ 39 , 40 ], possibly contributing to the increased CHD risk associated with the higher BMI group. Linolenate (18:3n3 or 6) was associated with elevated c-peptide, DBP, T3 and total iron-binding capacity.…”

Hyperthyroidism in patients with ischaemic heart disease after iodine load induced by coronary angiography: Long‐term follow‐up and influence of baseline thyroid functional status

“…Hintze et al observed a rate of 3.8% of subclinical hyperthyroidism in 788 patients with IHD before undergoing coronary angiography, while another study from Germany observed 0.3% . More recently, Marraccini et al reported that hyperthyroidism was 2% of 1572 patients admitted for coronary angiography, and Ling et al studied 1799 consecutive adults over 30 who underwent coronary angiography for suspected IHD who showed less than 1% of spontaneous hyperthyroidism at baseline.…”

Impact of persistent subclinical hypothyroidism on clinical outcomes in non‐ST‐segment elevation acute coronary syndrome undergoing percutaneous coronary intervention

“…However, there are other studies that drew the opposite conclusion that neither FT4 nor TSH was related to ln (Gensini score). 26 It is worth noting that Lee et al 9 found that SCH was associated with re-PCI after in-stent restenosis, suggesting that SCH may aggravate coronary lesions by increasing stent intimal hyperplasia. We also observed that the severity of coronary artery lesions in patients with SCH was significantly higher than that in patients with ET.…”