Impact of persistent subclinical hypothyroidism on clinical outcomes in non‐ST‐segment elevation acute coronary syndrome undergoing percutaneous coronary intervention

Abstract

Background: Data on the association of subclinical hypothyroidism (SCH) with the severity of coronary artery disease and major adverse cardiovascular and cerebral events (MACCE) in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS) after percutaneous coronary intervention (PCI) are limited and conflicting. Objective: We established the baseline rate of SCH and followed the trajectory of thyroid-stimulating hormone (TSH) values during and after hospitalisation for PCI for up to six months and determined whether persistent SCH was associated with the severity of coronary artery disease and MACCE in patients with NSTE-ACS after PCI. Design: Population-based prospective cohort study. Patients: We included patients with NSTE-ACS who underwent PCI with simple balloon angioplasty or stent implantation for coronary heart disease. Measurements: Thyroid function tests of patients before PCI and 1 day, 1 week, 1 and 6 months after PCI were performed. Cases showing transient SCH were excluded. Patients were divided into two groups based on the results of four TSH tests: 0.27-4.2 mIU/L (n = 1472, 89.7%) and >4.2 mIU/L (n = 170, 10.4%). The risk factors for the severity of coronary artery lesions were estimated using multinomial logistic regression analysis. Univariate and multivariate Cox regression analyses were used to study the relationship between TSH and MACCE.Results: Among 1642 patients, there were 1070 males (65.2%) and 572 females (34.8%), with an average age of 62.5 ± 9.6 years. SCH patients had a wider range of diseased vessels and a higher number of diseased vessels (p < .05). TSH level was an

Risk Factors Leading to ST Elevation Myocardial Infarction in Young Patients Presenting to a Tertiary Care Hospital, Islamabad Pakistan

“…Also proven from previous study showing that STEMI is associated with HTN, Family history and obesity in young adults specially in males it is found to be prevalent. 11,12,13 American heart association also showed that young adults having Higher blood pressure were more prone to develop Myocardial infarction with higher ST segment elevation. STEMI also found to be associated with obesity and male gender and younger individuals al these results are in accordance with results of this study.…”

A Rare Encounter: Unstable Vasospastic Angina Induced by Thyrotoxicosis

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“…Numerous studies compared the thrombolytic therapy with coronary intervention and found that the later one is more effective in terms of reduced mortality rate, stroke, and reinfarction [19,20]. In a study conducted by Han et al [21], increasing rate of mortality were observed in AMI patients with RBBB treated with angioplasty.…”