Thyroid Function in the Prenatal and Neonatal Bovine

Hernández, Marcelino; Etta, K. M.; Reineke, E. P.; Oxender, W. D.; Hafs, H. D.

doi:10.2527/jas1972.345780x

Cited by 29 publications

(18 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Available literature on the histological, ultrastructural studies on the development of the thyroid gland in several exotic wild and domestic animal species including cattle are abundant (Fujita, 1975;Fujita, 1988;Hernandez et al, 1972;Schafie and Mashaly, 1974;Roy et al, 1978;Pardehi, 1981;Baishya et al, 1985;Sawicki and Zabel, 1997;Sawicki and Zabel, 1999;Hajovska, 2002;Jelinek et al, 2003;Peksa et al, 2011). Although, these studies exist on thyroid morphology, there is scant published literature on morphology of thyroid of our indigenous domestic animals of the humid tropical environment.…”

mentioning

confidence: 99%

Histologic and ultrastructural observations on the thyroid gland of the White Fulani (Zebu) cattle in Northern Nigeria

Igbokwe¹,

Ezeasor²

2015

Afr. J. Biotechnol.

View full text Add to dashboard Cite

mentioning

confidence: 99%

Histologic and ultrastructural observations on the thyroid gland of the White Fulani (Zebu) cattle in Northern Nigeria

Igbokwe¹,

Ezeasor²

2015

Afr. J. Biotechnol.

View full text Add to dashboard Cite

“…In cattle, iodide trapping in the thyroid gland of the fetus begins at about 60 days [4]. Blood T 4 levels begin to increase in the middle fetal stage, and increase until twice the level of the dams in the late fetal stage [3]. With regard to T 3 levels, these are low in the fetal stage, but increase until they reach the level of the dams at birth [13].…”

mentioning

confidence: 99%

“…This stimulation is transmitted by TRH in the hypothalamus, leading to increased secretion of TSH, and subsequently increased secretion of T 4 in the thyroid [14]. Further, the basal metabolic rate of newborn calves increases rapidly after birth, attains a peak at 2-4 days after birth, decreases rapidly until 8 days, and thereafter decreases gradually and stabilizes after 21 days [3]. Calves spend the stored thyroid hormone on active energy metabolism just after birth.…”

mentioning

confidence: 99%

Changes in Serum Thyroid Hormone Levels in Newborn Calves as a Diagnostic Index of Endemic Goiter.

Takahashi

Ducusin

et al. 2001

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

ABSTRACT. Maximum serum thyroxine (T 4 ) and triiodothyronine (T 3 ) levels of healthy calves were seen at 1 day after birth, and thereafter rapidly decreased until 5 days after birth. They stabilized until 2 weeks after birth, then gradually decreased until 4 weeks after birth. Serum T 4 levels of calves with endemic goiter tended to be lower than those of healthy ones, but showed similar levels to those of adult cows. T 3 levels of calves with goiter were similar to those of healthy ones, but showed higher variation. T 4 /T 3 ratio of calves with goiter were significantly lower than those of healthy ones and adult cows. While individual levels of serum T 4 and T 3 at just after birth could not be considered as a diagnostic index, the T 4 /T 3 ratio could be adopted as a diagnostic index of endemic goiter. The histopathological changes of an enlarged thyroid gland together with other evidence of hypothyroidism are necessary to diagnose endemic goiter in newborn calves [6,9,11]. However, since the energy metabolic rate is higher in newborn calves, thyroid hormone levels may be more variable just after birth. In this paper, the thyroid hormone levels of calves with goiter were compared with those of healthy calves and adult cows to investigate a possible diagnostic index of endemic goiter in calves.Six healthy Holstein calves were examined. Newborn Holstein calves with goiter (n=34) found at 3 farms in the Tokachi district in Hokkaido were also examined. The diagnosis of endemic goiter was based on histopathological findings of enlarged thyroid glands. The blood of healthy calves was collected from the jugular vein at the following times: just after birth, 1, 3, 5, 7 days after birth, 2, 3, 4 weeks after birth, and 2 months after birth. The blood of calves with endemic goiter was collected just after birth (n=13), 1 (n=8) and 3 (n=5) days after birth, and at 2 (n=4) and 4 (n=4) weeks after birth. As a control, the blood of healthy 18-21 month-old adult cows (n=6) was also examined. Serum was separated quickly from collected blood then frozen at -20°C until determination of the thyroid hormone levels.Serum thyroxine (T 4 ) and serum triiodothyronine (T 3 ) of healthy calves, calves with goiter and healthy adult cows were determined by the RIA method (SPAC T 4 RIA Kit and SPAC T 3 RIA Kit, Daiichi RI institute) and the T 4 /T 3 ratio was calculated. Differences of thyroid hormone levels among healthy calves, calves with goiter and healthy adult cows were considered significant if p values were <0.05 or <0.01 by Student's t test. Figure 1 shows the changes in serum levels of thyroxine (T 4 ), triiodothyronine (T 3 ) and the T 4 /T 3 ratio in healthy calves and calves with goiter. These were compared with those of adult cows. Serum T 4 levels of healthy calves until 7 days after birth were significantly (p<0.01) higher than those of adult cows, and showed the maximum levels at 1 day after birth. Thereafter, they decreased rapidly until 5 days after birth. The levels at 2 weeks after birth were significantly (p<0.05) ...

show abstract

“…The thyroid status of neonatal calves, presented by blood TH concentrations, was studied by many authors [27][28][29][30]. It was established that serum T 4 and T 3 in calves aged up to 7 days, are signifi cantly higher than in adult cows [11].…”

Section: Discussionmentioning

confidence: 99%

Placental Iodothyronine Deiodinases Expression in Pregnant Cows Exposed to Propylthiouracil (Ptu) and Thyroid Axis Activity of their Calves

et al. 2016

View full text Add to dashboard Cite

The aim of our study was to investigate if the thyroid axis of newborn calves is affected by prenatal application of propylthyouracil (PTU). The study included 20 late pregnant Holstein cows. One group (n=10) was treated with PTU (4 mg/kg of BW daily) from day 20 before expected calving until the day of calving. The other group (n=10) was non-treated. Placental samples of dams were obtained for measuring mRNA expression of iodothyronine deiodinases type I (D1), type II (D2) and type III (D3). After parturition calves were separated from the dams and included in the study. Blood samples were taken daily from each calf starting on the day of birth until day 7 of age. Blood T 3, T 4 and TSH concentrations were measured. PCR analysis of the placental tissue revealed an abundance of all three types of placental deiodinases in non-treated cows, and a signifi cant elevation of mRNA levels for all three types of deiodinases after PTU treatment. Calves that originated from dams treated with PTU had signifi cantly lower T 3 and T 4 and signifi cantly higher TSH concentrations compared to non-treated calves during the fi rst 2 days of life. Starting from day 4 until day 6 of life the opposite effect was observed meaning that calves prenatally exposed to PTU had signifi cantly higher T 3 and T 4 and slightly lower TSH. Our study, for the fi rst time, provides information related to iodothyronine deiodinases mRNA expression in bovine placenta, and confi rm that PTU treatment of pregnant dams provokes depression of thyroid function in newborns during the fi rst days of life.

show abstract

Thyroid Function in the Prenatal and Neonatal Bovine

Cited by 29 publications

References 7 publications

Histologic and ultrastructural observations on the thyroid gland of the White Fulani (Zebu) cattle in Northern Nigeria

Histologic and ultrastructural observations on the thyroid gland of the White Fulani (Zebu) cattle in Northern Nigeria

Changes in Serum Thyroid Hormone Levels in Newborn Calves as a Diagnostic Index of Endemic Goiter.

Placental Iodothyronine Deiodinases Expression in Pregnant Cows Exposed to Propylthiouracil (Ptu) and Thyroid Axis Activity of their Calves

Contact Info

Product

Resources

About