Thyroid function in relation to burden of PCBs, p,p′-DDE, HCB, mirex and lead among Akwesasne Mohawk youth: a preliminary study

Schell, Lawrence M.; Gallo, Mia V.; DeCaprio, Anthony P.; Hubicki, Lech; Denham, Melinda; Ravenscroft, Julia

doi:10.1016/j.etap.2004.01.010

Cited by 45 publications

(32 citation statements)

References 28 publications

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“…Likewise, inverse associations between PCBs and T 3 levels were also previously observed in the wives of Swedish fishermen (Hagmar et al 2001b) and in German schoolchildren (Osius et al 1999), while another study among Dutch women reported an inverse association with T 3 that was also accompanied by an inverse association with T 4 and a positive association with TSH (Sala et al 2001). Other studies have reported an inverse association between PCBs, and T 4 and/or a positive association between PCBs and TSH, with no association between PCBs and total T 3 (Schell et al 2004;Hagmar 2003;Persky et al 2001;Emmett et al 1988), while another reported no associations between PCBs and thyroid hormones among 160 neonates from North Carolina from 1978 to 1982 (Longnecker et al 2000).…”

Section: Discussionmentioning

confidence: 97%

“…In addition, several human studies have investigated associations between levels of these compounds in the body and thyroid hormone levels (Takser et al 2005;Schell et al 2004;Bloom et al 2003;Hagmar 2003;Pelletier et al 2002;Hagmar et al 2001a;2001b;Persky et al 2001;Sala et al 2000;Longnecker et al 2000;Osius et al 1999;Koopman-Esseboom et al 1994;Emmett et al 1988). However, study populations have differed greatly and results have not been consistent across studies.…”

Section: Introductionmentioning

confidence: 99%

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Serum PCBs, p,p′-DDE and HCB predict thyroid hormone levels in men

Meeker

Altshul²,

Hauser

2007

Environmental Research

123

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Polychlorinated biphenyls (PCBs) and some organochlorine pesticides, which continue to be measurable in a high proportion of samples from the general population, have been found to alter thyroid hormone levels in animals and humans. However, studies of these relationships in adult men are limited and results across studies have been inconsistent. In the present study, we measured serum levels of 57 PCB congeners, dichlorodiphenyldichloroethylene (p,p′-DDE, a stable metabolite of DDT), and hexachlorobenzene (HCB), as well as free T 4 , total T 3 , and TSH, in 341 adult men recruited from an infertility clinic from 2000-2003. In multivariate linear regression, there were positive associations between p,p′-DDE and both free T 4 and total T 3 , and an inverse association between p,p′-DDE and TSH. Conversely, for PCBs there was only a suggestive inverse association between PCB 153 and total T 3 when potential confounding variables were considered. However, when results were additionally adjusted for p,p′-DDE, inverse associations with T 3 were significant for PCB 138, PCB 153, sum of PCBs and three different PCB groupings, and HCB, while the positive associations between p,p′-DDE and T 3 also remained. In conclusion, serum concentrations of PCBs, p,p′-DDE and HCB were associated with circulating thyroid hormone levels in adult men.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Serum PCBs, p,p′-DDE and HCB predict thyroid hormone levels in men

Meeker

Altshul²,

Hauser

2007

Environmental Research

123

View full text Add to dashboard Cite

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“…A second finding from our research partnership with the Akwesasne community addresses the relationship between PCB levels and hormones related to thyroid function (Schell et al, 2004). The 16 PCB congeners found in the majority of study participants were grouped together.…”

Section: Research Results From the Partnershipmentioning

confidence: 97%

Advancing biocultural models by working with communities: A partnership approach

Schell

Ravenscroft

Gallo

et al. 2007

American J Hum Biol

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Culture and human behavior are recognized today as major forces acting on human biological variation around the world. Studies of the relationships between biology and processes, such as modernization, urbanization, and social stratification, are prominent in our journals and meetings. An ongoing study of the interrelationships between toxicant exposure (organochlorines, lead, and mercury), health, and culture among youth of the Mohawk Nation at Akwesasne is located within this context and is used to analyze the strengths and challenges of a partnership approach to biocultural research. To assist in modeling the complex relationships between health, behavior, and culture, we have employed concepts from contemporary social theory, integrated qualitative and quantitative research, and implemented community-based research principles to develop a partnership approach to research in human biology. The community is directly involved in identifying research goals, developing research protocols appropriate for local cultural sensitivities and complexities, implementing the protocols in the field, and collaborating in the analysis and publication of results. We show the utility of this approach for understanding the relationships of toxicants to behavior and biological outcomes (adolescent growth, sexual maturation, and endocrine system alteration); as well as how it facilitates the agency of participants and communities involved in research, and brings greater social engagement to the development of the new human biology.

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“…In subjects from highly PCB-exposed areas, the PCB concentration in blood samples negatively correlated to circulating TH levels (Hagmar et al, 2001a;Persky et al, 2001). However, few studies also demonstrated positive correlation between PCB exposure and TSH (Osius et al, 1999;Schell et al, 2004). By contrast, other studies found no association between PCBs and thyroid secretion (Bloom et al, 2003;Hagmar et al, 2001b;Sala et al, 2001).…”

Section: Polychlorinated Biphenylsmentioning

confidence: 89%