Thyroid function during pregnancy in women with past Graves' disease

Luton, Dominique; Gac, Isabelle Le; Noël, Michèle; Gadrey, Jean; Polak, Michel

doi:10.1111/j.1471-0528.2005.00736.x

Cited by 10 publications

(5 citation statements)

References 9 publications

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“…Thyroid function changes have been associated with adverse outcomes 1,2 during pregnancy and maternal thyroid dysfunction. Women with hypothyroidism or hyperthyroidism will have a higher risk of low birth weight.…”

Section: Introductionmentioning

confidence: 99%

Establishment of self-sequential longitudinal reference intervals of maternal thyroid function during pregnancy

Wang

Huang

et al. 2010

Exp Biol Med (Maywood)

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The objective of this study is to establish self-sequential longitudinal reference intervals of thyroid function in normal pregnant women. According to the selection criteria, 301 cases were taken as the normal pregnant population to establish a normal reference range. Meanwhile, 150 healthy women were selected as the normal non-pregnant control group. To establish their own self-sequential longitudinal reference intervals, we collected samples five times in every case throughout the gestation (including first trimester, second trimester, third trimester, prenatal and postpartum), and detected the levels of thyroid stimulating hormone (TSH), free thyroxine (FT4), thyroid peroxidase antibodies (TPO-Ab), and then established the self-sequential longitudinal reference intervals. The levels of TSH, FT4 and TPO-Ab were quantified by electrochemistry immunoassay (ECL) and statistically analyzed using SPSS 13.0 software. Serum TSH of normal pregnant women was at a low level in the first trimester (P < 0.05) and began to rise continuously. Not until prenatal phase was it restored to the non-pregnant state (P > 0.05). During pregnancy, serum FT4 of normal pregnant women were consistently lower than non-pregnant levels (P < 0.05) and kept at low levels. Serum TPO-Ab increased significantly in the third trimester and prenatal phase (P < 0.05). Of normal pregnant women, 6.5% were TPO-Ab positive. In conclusion, the reference intervals in our case will reflect the changes of thyroid function in pregnant women more realistically, resulting in a more accurate value for clinical diagnosis and therapy.

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Section: Introductionmentioning

confidence: 99%

Establishment of self-sequential longitudinal reference intervals of maternal thyroid function during pregnancy

Wang

Huang

et al. 2010

Exp Biol Med (Maywood)

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“…A dysfunctional thyroid gland during pregnancy can affect both mother and fetus [1-3]. One example is the maternal hypothyroidism and hyperthyroidism occurring at the beginning and end of pregnancy that may increase the risk of low birth weight and the likelihood of a Caesarean section [4,5].…”

Section: Introductionmentioning

confidence: 99%

Thyroid hormones according to gestational age in pregnant Spanish women

et al. 2009

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BackgroundThyroid function changes during pregnancy and maternal thyroid dysfunction have been associated with adverse outcomes. Our aim was to evaluate thyroid hormones levels in pregnant women resident in Aragon, Spain.FindingsSamples for 1198 pregnant women with no apparent thyroid disorders were analyzed, using paramagnetic microparticle and chemiluminescent detection technologies, in order to determine levels of thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), thyroid peroxidase antibodies (TPO-Ab), and thyroglobulin antibodies (Tg-Ab). Of the women in our sample, 85.22% had normal values for TPO-Ab and Tg-Ab and 14.77% had results revealing the presence of autoimmune diseases of the thyroid. The thyroid hormone reference values obtained according to gestational age (in brackets) were as follows: for free T3, values were 3.38 ± 0.52 pg/mL (<11 weeks), 3.45 ± 0.54 pg/mL (11-20 weeks), 3.32 ± 0.43 pg/mL (21-30 weeks), 3.21 ± 0.53 pg/mL (31-36 weeks), and 3.23 ± 0.41 pg/mL (>36 weeks); for free T4, values were 1.10 ± 0.14 ng/dL (<10 weeks), 1.04 ± 0.14 ng/dL (11-20 weeks), 0.93 ± 0.12 ng/dL (21-30 weeks), 0.90 ± 0.13 ng/dL (31-36 weeks), and 0.80 ± 0.21 ng/dL (>36 weeks); and for TSH, values were (μIU/mL): 1.12 ± 0.69 (<10 weeks), 1.05 ± 0.67 (11-20 weeks), 1.19 ± 0.60 (21-30 weeks), 1.38 ± 0.76 (31-36 weeks), and 1.46 ± 0.72 (>36 weeks).ConclusionPregnant women with normal antibody values according to gestational age had values for FT4 and TSH, but not for FT3, that differed to a statistically significant degree. The values we describe can be used as reference values for the Aragon region of Spain.

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“…Maternal hypothyroidism, even very mild, can have adverse effects on both pregnancy outcome and children's development (2). Maternal thyroid dysfunction or only the presence of thyroid-specific antibodies will increase the risk of early abortion, neonatal morbidity (3,4) and some obstetrical complications (5,6), such as premature delivery, gestational hypertension, pre-eclampsia and placental abruption. Accurate evaluation of thyroid function is therefore very important during pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Clinical Evaluation with Self-sequential Longitudinal Reference Intervals: Pregnancy Outcome and Neonatal Thyroid Stimulating Hormone Level Associated with Maternal Thyroid Diseases

YuanI

Wang²,

Huang³

et al. 2018

West Indian Med J

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Objective: We attempted to evaluate maternal thyroid function in a new self-sequential longitudinal reference interval (SLRI) which we established recently. By this method, we analysed the correlation between pregnancy outcome, neonatal thyroid stimulating hormone (TSH) level and maternal thyroid diseases. Methods: A total of 1744 pregnant women participated in the study and 1747 babies were born from those women (three bore twins). The levels of TSH, free thyroxine (FT4) and thyroid peroxidase antibodies (TPO-Ab) of mothers were quantified by electrochemistry immunoassay (ECL). The levels of neonatal blood TSH were detected by time-resolved fluorescence immunoassay (TRFIA). All data were collected and statistically analysed by SPSS 13.0 software. Results: With our new SLRI method, we found that 0.11%~3.84% pregnant women would get thyroid diseases. Subclinical hypothyroidism was the most common maternal thyroid disorder. Being positive for thyroid peroxidase antibodies was a significant risk factor of subclinical hypothyroidism during pregnancy. The median, P2.5~P97.5, and interquartile range (IQR) of neonatal TSH (N-TSH) of 1747 babies were 2.72 mIU/L, 0.10~8.01 mIU/L and 2.62 mIU/L, respectively; 28.6% of pregnant women with thyroid diseases developed pregnancy complications. The prevalence was significantly higher than in the normal thyroid function group (p < 0.001). The levels of N-TSH were low correlated with maternal TSH levels (p < 0.05), but there were no significant correlations between N-TSH and maternal FT4 and maternal TPO-Ab (p > 0.05). Conclusions: Thyroid disorders, especially subclinical hypothyroidism, are common in pregnant women. These disorders are associated with pregnancy and fetal outcome. Routine maternal thyroid function screening is important and should be recommended.

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Thyroid function during pregnancy in women with past Graves' disease

Cited by 10 publications

References 9 publications

Establishment of self-sequential longitudinal reference intervals of maternal thyroid function during pregnancy

Establishment of self-sequential longitudinal reference intervals of maternal thyroid function during pregnancy

Thyroid hormones according to gestational age in pregnant Spanish women

Clinical Evaluation with Self-sequential Longitudinal Reference Intervals: Pregnancy Outcome and Neonatal Thyroid Stimulating Hormone Level Associated with Maternal Thyroid Diseases

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