Thyroid function and periodic paralysis

Engel, Andrew G.

doi:10.1016/0002-9343(61)90104-8

Cited by 91 publications

(32 citation statements)

References 33 publications

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“…Although, in general, the prophylactic effect of potassium on an attack of apparent periodic paralysis is questioned, it is not denied that a high potassium intake prevents a mild attack of paralysis. However, the incidence of periodic paralysis in Japan is still high compared with that in the United States and Europe [3]. One of the reasons for this high incidence is genetic predisposition.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Incidence of Association of Periodic Paralysis and Hyperthyroidism in Japan in 1957 and 1991.

et al. 1992

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Abstract. Periodic paralysis has been known to be associated with thyrotoxicosis in Japan. The incidence was 8.6% among male and 0.4% among female thyrotoxic patients according to a survey performed in the three major thyroid clinics in Japan in 1957. To determine the changes in the incidence during the intervening 34 years, the same type of survey was carried out again in 1991 at the same three major thyroid clinics previously involved. The incidence of paralysis in 1991 was 4.3% among male and 0.04% among female thyrotoxic patients, indicating more than a 40% decrease in the incidence. The possible cause of the decrease is related to the changes in food consumption, namely, to the fact that less carbohydrate and more potassium were taken in 1991 than in 1957.

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Section: Discussionmentioning

confidence: 99%

Comparison of the Incidence of Association of Periodic Paralysis and Hyperthyroidism in Japan in 1957 and 1991.

et al. 1992

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“…Consistent with this postulate and the possibility of structural lesions which may persist in a euthyroid environment, is the in triguing but unconfirmed observation that kidneys from thyroxin-treated dogs excrete more urine than kidneys from euthyroid animals when trans planted into normal dogs [22]. [43,90], Although the acute attack is usually accompanied by hypokalemia, the role of disturbed K metabolism in thyrotoxic periodic paralysis is not clear, since plasma K is normal between attacks and Ke is no different from that of thyrotoxic patients free of paral ysis [125].…”

mentioning

confidence: 81%

Thyroid Hormone and the Kidney

Katz

Emmanouel

Lindheimer

1975

Nephron

174

127

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Thyroid hormones affect both renal morphology and function. They are required for kidney growth and development, and thyroid deficiency results in decreased renal plasma flow and glomerular filtration rate and in impaired urinary concentration and dilution. Thyroid hormones also influence membrane transport and electrolyte metabolism, and alterations in mineral metabolism in hyperthyroidism frequently cause calcium nephropathy which affects renal function adversely. The kidney plays an important role in the peripheral metabolism of iodine and thyroid hormones, and thyroid function is altered in certain kidney diseases, particularly chronic renal failure. The pathogenesis of these alterations is currently under active investigation.

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“…The disorder occurs most frequently in Oriental men (1 , 2) in their second and third decades (3,4). Most reported cases are associated with Graves' disease (5).…”

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confidence: 99%

A case of thyrotropin (TSH)-secreting tumor complicated by periodic paralysis.

et al. 1990

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A 27-year-old man had symptoms of hyperthyroidism and periodic paralysis. While hyperthyroid, his serum thyrotropin (TSH) level was inappropriately elevated at 6.4/iU/ml. The serum alpha subunit level was also elevated. MRimaging revealed a pituitary tumor and transsphenoidal adenomectomywas performed. Immunocytochemistry with an antibody directed against the beta-subunit of TSHrevealed a TSH-secreting tumor.This is the first case of hyperthyroidism due to a TSH-secreting pituitary tumor complicated by periodic paralysis. This association indicates that thyrotoxicosis may induce paralysis in susceptible persons by a mechanismwhich is not autoimmune.

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Thyroid function and periodic paralysis

Cited by 91 publications

References 33 publications

Comparison of the Incidence of Association of Periodic Paralysis and Hyperthyroidism in Japan in 1957 and 1991.

Comparison of the Incidence of Association of Periodic Paralysis and Hyperthyroidism in Japan in 1957 and 1991.

Thyroid Hormone and the Kidney

A case of thyrotropin (TSH)-secreting tumor complicated by periodic paralysis.

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