Thyroid Function and Exercise

Bernet, Victor; Wartofsky, Léonard

doi:10.1007/978-1-59259-016-2_6

Cited by 5 publications

(10 citation statements)

References 97 publications

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“…explained by the status of negative energy balance caused by strenuous physical exercise (39). The negative energy balance is shown by the clear decrease in body weight that was recorded in our study as well as in other studies in subjects at HA (10,11).…”

Section: Discussionsupporting

confidence: 81%

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Endocrine and metabolic responses to extreme altitude and physical exercise in climbers

Benso

Broglio

Aimaretti

et al. 2007

European Journal of Endocrinology

106

103

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Context: Chronic hypoxia induces complex metabolic and endocrine adaptations. High-altitude (HA) exposure is a physiological model of hypoxia. Objective: To further investigate the endocrine and metabolic responses to extreme HA. Methods: We studied nine male elite climbers at sea level and at 5200 m after climbing Mt. Everest. Results: After 7 weeks at HA, body weight was reduced (P!0.05); regarding endocrine variables we observed: a) an increase of 2-h mean GH concentration (P!0.05) as well as of total IGF-I and IGF binding protein-3 levels (P!0.05 for both); b) a prolactin increase (P!0.05) coupled with testosterone decrease (P!0.01) and progesterone increase (P!0.05) without any change in estradiol levels: c) no change in cortisol, ACTH, and dehydroepiandrosterone sulfate (DHEAS) levels; d) an increase in free thyroxine (P!0.05) and free tri-iodothyronine (T 3 ) decrease (P!0.05) but no change in TSH levels; e) a plasma glucose decrease (P!0.05) without any change in insulin levels; f) an increase in mean free fatty acid levels (P!0.05); g) despite body weight loss, leptin levels showed non-significant trend toward decrease, while ghrelin levels did not change at all. Conclusions:The results of the present study in a unique experimental human model of maximal exposure to altitude and physical exercise demonstrate that extreme HA and strenuous physical exercise are coupled with specific endocrine adaptations. These include increased activity of the GH/IGF-I axis and a low T 3 syndrome but no change in ghrelin and leptin that was expected taking into account body weight decrease. These findings would contribute to better understanding human endocrine and metabolic physiology in hypoxic conditions. European Journal of Endocrinology 157 733-740

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Section: Discussionsupporting

confidence: 81%

“…The effects of HA, hypoxia, and physical exercise on the thyroid axis have been more extensively studied (12)(13)(14)39). Although physical exercise per se is not considered as having a significant influence on thyroid function (39), environmental conditions have been reported to play a relevant role.…”

Section: Discussionmentioning

confidence: 99%

Endocrine and metabolic responses to extreme altitude and physical exercise in climbers

Benso

Broglio

Aimaretti

et al. 2007

European Journal of Endocrinology

106

103

View full text Add to dashboard Cite

show abstract

“…It controls how quickly the body burns energy, makes proteins, and how sensitive the body should be to other hormones. These hormones regulate the rate of metabolism and affect the growth and rate of function of many other systems in the body (Wartofsky, 1995;Bernet and Wartofsky, 2000;McMurray and Hackney, 2000).…”

Section: Introductionmentioning

confidence: 99%

“…Its primary functions are to increase protein breakdown, inhibite glucose uptake and increase lipolysis. The level of serum cortisol is effected by many factor such as intensity, duration and timing of exercise, type of exercise, age, altitude, environmental temperature and psychology (Bernet and Wartofsky, 2000;Deligiannis et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

The effects of maximal aerobic exercise on cortisol and thyroid hormones in male field hockey players

Beyleroğlu¹

2011

Afr. J. Pharm. Pharmacol.

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Some metabolic and endocrine functions might be influenced by exercise and it leads to changed concentrations of hormone secretions in humans. In order to determine the changes of thyroid hormones (THs) related to shuttle run exercise (SRE), 14 field hockey players and their thyroid stimulating hormones (TSH) free T3 (fT3), free T4 (fT4) were included in this study, and cortisol levels were measured three times; before the exercise, just after the exercise and one hour later after exercise. The results of this study showed that there were no statistically significant differences among three measurements in the serum levels of TSH and thyroid hormones. However, both fT3 and TSH were significantly decreased in one hour later after exercise, whereas no change was observed in fT4. Cortisol concentrations were slightly increased immediately after SRE. In conclusion, serum levels of thyroid stimulating hormone and thyroid hormones were affected by maximal aerobic exercise.

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“…Atletas com perda de peso excessiva e amenorréia podem apresentar, juntamente com outras alterações pituitárias, a síndrome do T3 baixo, onde existe predomínio do rT3 (49). Existem evidências de que a produção e utilização de Triiodotironina (T3) apresenta forte correlação com a quantidade de massa muscular em atletas (50).…”

Section: Efeitos Do Exercício No Eixo Hipotálamo-hipó -Fise-tireóideunclassified

Alterações hormonais da mulher atleta

Pardini¹

2001

Arq Bras Endocrinol Metab

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RESUMOO propósito desta revisão é focalizar o exercício como modulador da reprodução humana, resumir e integrar os dados atuais referentes ao eixo hipotálamo-hipófise-gonadal na mulher atleta. A prevalência de disfunção menstrual, tal como fase lútea deficiente, oligomenorréia, amenorréia e retardo puberal, é maior entre o grupo de mulheres atletas quando comparado à população geral. Vários fatores podem predispor e contribuir para o desenvolvimento das irregularidades menstruais durante o programa de atividade física, sendo considerados fatores de risco, entre eles, baixo peso, teor de gordura corporal e estados hipoestrogênicos. O hipoestrogenismo pode afetar o pico de massa óssea na puberdade e acarretar perda óssea prematura irreversível. O artigo revisa os efeitos fisiológicos do treinamento físico nos vários sistemas endócrinos e aborda informações clínicas a respeito dos distúrbios hormonais especí-ficos da mulher atleta. ABSTRACTThe purpose of this review is to focus the exercise as a modulator of human reproduction and to summarize and integrate current data concerning the hypothalamus-pituitary-gonadal axis in exercising women. The prevalence of menstrual dysfunctions, as the luteal phase deficiency, oligomenorrhea, amenorrhea and menarcheal delay are greater among athletes than in the general population. Many factors undergo changes during the course of an athletic training program and any or all of these may contribute to disturbances in menstrual cyclicity. A number of risk factors have been identified as predisposing women to the development of menstrual irregularities, such as low body weight, body fat and hypoestrogenic status. Hypoestrogenism may affect peak bone mass in the puberty and lead to irreversible premature bone loss. This paper reviews the physiologic effects of fitness training on various endocrine systems and provides clinical information about specific endocrine disturbances in athlete women. (Arq Bras Endocrinol Metab 2001;45/4:343-351) Keywords: Fitness training; Amenorrhea; Osteoporosis; Eating disorders; Endocrine disturbances. ALTERAÇÕES HORMONAIS DA MULHER ATLETAA participação em competições esportivas e programas de atividade física tem adquirido importância crescente na vida da maior parte das crianças e adolescentes. Nos últimos 20 anos o número de mulheres atletas, em particular, tem aumentado consideravelmente. A participação feminina cresceu cerca de 600% abrangendo um total de mais de 1,9 milhões de mulheres atletas (1). Uma conseqüência inevitável e talvez lamentável desse fenômeno tem sido a revisão Alterações Hormonais da Mulher Atleta

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Thyroid Function and Exercise

Cited by 5 publications

References 97 publications

Endocrine and metabolic responses to extreme altitude and physical exercise in climbers

Endocrine and metabolic responses to extreme altitude and physical exercise in climbers

The effects of maximal aerobic exercise on cortisol and thyroid hormones in male field hockey players

Alterações hormonais da mulher atleta

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