Thyroid FNA diagnostics in a real‐life setting: Experiences of the implementation of the Bethesda system in Finland

Paajanen, Ilona; Metso, Saara; Jaatinen, Pia; Kholová, Ivana

doi:10.1111/cyt.12513

Cited by 12 publications

(12 citation statements)

References 22 publications

(60 reference statements)

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“…There were also 12 carcinomas and 10 cases of thyroiditis. Despite the low number of cases when compared with others FNAC series, the distribution of the results is similar to those described in the literature …”

Section: Resultssupporting

confidence: 83%

“…Despite the low number of cases when compared with others FNAC series, the distribution of the results is similar to those described in the literature. 21 Lesions from salivary glands were also frequently sampled (n = 308 cases, from which 195 were parotid). The most frequent diagnoses in salivary glands were lympho-epithelial lesions (n = 112), mainly lymphoepithelial cysts.…”

Section: Fnac Of Thyroid Accounted For Only 5% Of All Cases (N = 314)mentioning

confidence: 99%

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Fine needle aspiration cytology in Mozambique: Report of a 15‐year experience

Carrilho

Ismail

Lorenzoni

et al. 2018

Diagnostic Cytopathology

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Background Fine needle aspiration cytology (FNAC) is an important diagnostic tool in a range of medical settings. It is fast, quick and a highly accurate diagnostic method and can be used, in settings with minimal laboratory infrastructures. Methods In this report, we describe the experience in the use of FNAC since it is introduction in 1996 in the Anatomical Pathology Service of the Maputo Central Hospital (MCH), along with more detailed data referring to 2009‐2010. Results The number of FNAC analyses increased gradually from 269 (4.1% of all pathologic tests of the Service) in 1996, when it was introduced in Mozambique, to 3234 (17% of all tests) in 2010. Lymph nodes were the organs most frequently biopsied, followed by breast and soft tissues. Inflammatory conditions, especially tuberculosis, were the most frequent diagnoses (22.2% of the cases), followed by hyperplastic conditions (20.6%), benign tumors (13.4%) and malignant tumors (12.3%). Conclusion Our results clearly demonstrate that even in an environment with poor laboratory resources, it is possible to establish a FNAC clinic that can provide a quick and precise diagnosis for clinicians to aid in early treatment interventions, especially in inflammatory diseases which were the majority of our cases.

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Section: Resultssupporting

confidence: 83%

Section: Fnac Of Thyroid Accounted For Only 5% Of All Cases (N = 314)mentioning

confidence: 99%

Fine needle aspiration cytology in Mozambique: Report of a 15‐year experience

Carrilho

Ismail

Lorenzoni

et al. 2018

Diagnostic Cytopathology

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“…We excluded a further 233 studies and finally selected 38 studies, which included 145,066 thyroid nodules, for meta‐analysis (Fig. ) . Among the included studies, 4 were prospective and 34 were retrospective.…”

Section: Resultsmentioning

confidence: 99%

Differences in surgical resection rate and risk of malignancy in thyroid cytopathology practice between Western and Asian countries: A systematic review and meta‐analysis

Vuong

Ngo

Bychkov

et al. 2019

Cancer Cytopathology

101

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There is increasing evidence showing that clinicians employ different management strategies in their use of The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). In this meta-analysis, we investigated the differences in diagnosis frequency, resection rate (RR), and risk of malignancy (ROM) between Western (ie, American and European) and Asian cytopathology practices. We searched PubMed . Proportion and 95% CIs were calculated using a random-effect model. We used independent sample t tests to compare frequencies, RR, and ROM between Western and Asian practices. We analyzed a total of 38 studies with 145,066 fine-needle aspirations. Compared with Asian practice, Western series had a significantly lower ROM in most of TBSRTC categories, whereas the RR was not statistically different. Focusing on indeterminate nodules, the RR in Western series was significantly higher (51.3% vs 37.6%; P = .048), whereas the ROM was significantly lower (25.4% vs 41.9%; P = .002) compared with those in Asian series. The addition of Asian cohorts increased ROM for most of diagnostic categories compared with the original TBSRTC. In conclusion, this study demonstrates a difference in Western and Asian thyroid cytology practice, especially regarding the indeterminate categories. Lower RR and higher ROM suggest that Asian clinicians adopt a more conservative approach, whereas immediate diagnostic surgery is favored in Western practice for indeterminate nodules. The addition of Asian series into a meta-analysis of TBSRTC altered ROM for several categories, which should be considered in future revisions of TBSRTC.

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“…The thyroid nodules could be detected by their imaging modalities (CT, MRI and US), but they could not accurately differentiate malignant and benign. FNA/FNB biopsy, an invasive and expensive method, are only applied to the suspected nodules [3].…”

Section: Introduction/backgroundmentioning

confidence: 99%

Elastography reduces over-medical procedures in thyroid nodules: a systematic review and meta-analysis

Ke¹,

Cheng²,

Jian-cang³

et al. 2020

Preprint

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Background To evaluate the diagnostic performance of elastography in the differentiating the malignancy from thyroid nodule. Methods The literature published in English or Chinese prior to December 2019 which diagnosed by elastography in thyroid nodules were reviewed and summarized. According the inclusion and exclusion criteria, the elegant theses were reserved. Quality of each study was evaluated by the qu ality a ssessment of d iagnostic a ccuracy s tudies tool (QUADAS). Comprehensive Meta-Analysis Version 2.0 was used to describe primary results and explore homogeneity. Publication bias analysis was evaluated by Review Manager 5.3. Meta-Disc version 1.4 was applied to explore threshold effect, and pool sensitivity and specificity. A Summary ROC curve was constructed to calculate the area under the curve. Results As the heterogeneity was mild, we performance on random effect model. The publication bias was negligible. The elastography showed high accuracy in the diagnosis of malignant. The pooled sensitivity and specificity with corresponding 95% confidence interval were 0.80 (0.78, 0.82) and 0.80 (0.79, 0.81) respectively. AUC of sROC was 0.9087. Sensitivity analysis demonstrated that the pooled estimates were stable and reliable. Conclusions The elastography has obvious sensitivity and specificity in differentiate malignant from the thyroid nodule. Several different types of elastography could achieve the same aim, but the cut-off value is associate with the purpose of the screen program and the subtypes of the technique.

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Thyroid FNA diagnostics in a real‐life setting: Experiences of the implementation of the Bethesda system in Finland

Cited by 12 publications

References 22 publications

Fine needle aspiration cytology in Mozambique: Report of a 15‐year experience

Fine needle aspiration cytology in Mozambique: Report of a 15‐year experience

Differences in surgical resection rate and risk of malignancy in thyroid cytopathology practice between Western and Asian countries: A systematic review and meta‐analysis

Elastography reduces over-medical procedures in thyroid nodules: a systematic review and meta-analysis

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