Thyroid disruptors and their possible clinical implications

Murthy, Mangala Bhaskar; Murthy, Bhaskar K

doi:10.4103/0253-7613.99351

Cited by 9 publications

(7 citation statements)

References 3 publications

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Section: Pathogenetic Interconnections At the Basis Of Vitiligo Anmentioning

confidence: 99%

“…We suggest that an important role in determining these events might be played also by heavy metals, pollutants, ionizing radiations, and other chemical substances [ 77 ] that induce the production of ROS and are considered endocrine disruptors [ 78 ]. These agents indeed are able to unfavorably affect thyroid or other endocrine gland functions through a wide range of molecular toxic mechanisms [ 78 ]. Therefore, an increased ROS accumulation due to environmental exposure could induce modifications of both melanocytic structures and thyroid proteins, leading to the frequently reported association of vitiligo and thyroid diseases [ 77 ].…”

Section: Pathogenetic Interconnections At the Basis Of Vitiligo Anmentioning

confidence: 99%

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Oxidative Stress and Immune System in Vitiligo and Thyroid Diseases

Colucci

Dragoni

Moretti

2015

Oxidative Medicine and Cellular Longevity

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Vitiligo is an acquired dermatological disease frequently associated with autoimmune thyroid disorders. Several theories have been proposed so far to unravel the complex vitiligo pathogenesis. Currently, the autocytotoxic and the autoimmune theories are the most accredited hypothesis, since they are sustained by several important clinical and experimental evidences. A growing body of evidences shows that autoimmunity and oxidative stress strictly interact to finally determine melanocyte loss. In this scenario, associated thyroid autoimmunity might play an active and important role in triggering and maintaining the depigmentation process of vitiligo.

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Section: Pathogenetic Interconnections At the Basis Of Vitiligo Anmentioning

confidence: 99%

Section: Pathogenetic Interconnections At the Basis Of Vitiligo Anmentioning

confidence: 99%

Oxidative Stress and Immune System in Vitiligo and Thyroid Diseases

Colucci

Dragoni

Moretti

2015

Oxidative Medicine and Cellular Longevity

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“…There is a growing interest about these agents and current literature shows that beside their induction of ROS, they are also considered as endocrine disruptors, because they are able to alter the structure or function of the endocrine system, causing adverse effects in the organism . In particular, their effect is noteworthy on thyroid , whose disorders are the most common comorbidities of vitiligo . It might be possible that an increased ROS accumulation due to environmental agents could induce a modification of both melanocytic structures and thyroid proteins, determining the frequently reported appearance of both vitiligo and thyroid diseases.…”

Section: Introductionmentioning

confidence: 99%

Commentary from the Editorial Board to Vitiligo: interplay between oxidative stress and immune system (Laddha et al.)

Colucci

Böhm

Moretti

2013

Experimental Dermatology

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Vitiligo pathogenesis is very puzzling, and novel mechanisms possibly involved in the development of this disorder are frequently explored. Recently, some authors proposed an interplay between oxidative stress and immune system at the basis of melanocyte loss. According to the experimental evidence, they suggest that exposition to environmental agents might lead to an association between vitiligo and other autoimmune diseases. Accordingly, it is proposed that increased reactive oxygen species due to environmental agents could induce a modification of both melanocytic structures and other tissue proteins, or might disregulate the immune system, influencing the appearance of vitiligo and autoimmune comorbidities.

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“…Azadirachta indica A. Juss (locally known as neem), prevalent in the tropical countries of the world, has been reported to possess anti-inflammatory, anti-pyretic, hypoglycaemic, antimicrobial and anti-cancerous activities [14][15][16][17][18][19]. The insecticidal properties of different parts of neem tree have been well documented.…”

Section: Introductionmentioning

confidence: 99%