Thyroid disorders in women with dysfunctional uterine bleeding

Abstract

Background: Thyroid hormones play a key role in the menstrual and reproductive function of women .It is recognized universally that menstrual disturbances may accompany clinical alteration in thyroid function and every clinician has encountered altered menstrual pattern among women suffering from thyroid disorders. The aim of this study was to find the incidence of thyroid disorders in Dysfunctional uterine bleeding and its correlation with menstrual patterns.Materials and Methods: A hospital based cross-sectional study including 75 cases with dysfunctional uterine bleeding attending the OPD of Nobel Medical College, where incidence of thyroid disorder was evaluated along with its correlation with menstrual patterns and histopathology.Results: The incidence of Gynecological OPD attendance due to abnormal uterine bleeding was 3%.and the incidence of thyroid dysfunction was 10.6% with hypothyroidism being the commonest. (9.3%). The commonest menstrual pattern found was menorrhagia/polymenorrhoea in 8 percent.Conclusion: Prevalence of hypothyroidism was more common in DUB. Thus every woman with menstrual irregularities should undergo thyroid assessment and this will ultimately avoid unnecessary intervention like misuse of hormonal treatment and hysterectomy.

Thyroid Dysfunction in Patient with Abnormal Uterine Bleeding in a Tertiary Hospital of Eastern Nepal: A Descriptive Cross-sectional Study

“…Hypothyroidism is generally known to cause heavy and irregular menstrual bleeding and hyperthyroidism is generally associated with hypo, oligo and amenorrhoea. 1 Our finding is similar to studies done in Nepal and India where researchers also found majority of AUB cases associated with euthyroidism followed by hypothyroidism, Subedi, et al 10 found 89.3% cases were euthyroid and 9.3% hypothyroid; Thakur, et al 11 found 84.9% as euthyroid and 13.9% hypothyroid; Kattel, et al 4 found 80% cases euthyroid and 11.1% as subclinical hypothyroid; Bhavani, et al 12 found 81% cases as euthyroid and 10% as subclinical hypothyroid; Gowri M, et al 13 found 77.6% cases as euthyroid and 17.6% cases as hypothyroid. In contrast according to Ajmani, et al 14 44% of the patients with menstrual disorder had thyroid disorders.…”

“…Bhavani, et al 12 found the incidence of menorrhagia to be 54%. Recent similar study in Nepal by Thakur, et al 11 also showed menorrhagia to be present among 40.5% cases of AUB. Second most common finding was metrorrhagia in our case which is similar to study done by Muzaffer, et al (35.4 %).…”

“…Second most common finding was metrorrhagia in our case which is similar to study done by Muzaffer, et al (35.4 %). 15 This is in contrast to study by Thakur, et al 11 in which polymenorrhoea was second most common finding.…”

Etiological factors of abnormal uterine bleeding according to PALM- COEIN classification in perimenopausal women in a tertiary care centre

“…Thus, there stands an association among non-structural causes of AUB and medical disorders. 13 Menorrhagia was the commonest menstrual disorder encountered in 52 cases (52%), followed by metrorrhagia 16%, menometrorrhagia 12%, hypomenorrhea 10%, polymenorrhea 8%, metropathica hemorrhagica in 2% cases. Our study correlated well with study done by Pillai GS et al 9 In our study 42% cases had leiomyoma which was found to be the leading cause of AUB in perimenopausal patients.…”

Clinico epidemiological profile of abnormal uterine bleeding in reproductive womens: a cross sectional study

“…Komathi R et al, also reported in their study that 76% cases had normal BMI followed by overweight in 14% cases. 17,18 Israel et al, also reported that AUB is a disease of multipara. Hamblen observed parity doubtlessly enhances the incidence of irregular bleeding.…”