Thyroid disorders in female subfertility

Rahman, Dilruba; Fatima, Parveen; Banu, Jesmine

doi:10.3329/jcmcta.v19i2.3871

Cited by 14 publications

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“…Sharma et al 24 in their study in India reported hypothyroidism in 20% and hyperthyroidism in 3% of primary infertile women. Similarly, a study done in 2007 in Bangladesh by Rahaman et al 20 showed hypothyroidism in 33.3% of infertile women and hyperthyroidism in none. Goswani et al 25 performed a study in Delhi in 2007 and found hypothyroidism in 8% infertile women and hyperthyroidism in 5%.…”

Section: Discussionmentioning

confidence: 81%

“…This high prevalence could be because infertile women having tubular endometriosis on diagnostic laparoscopy or hysteroscopy, with genital TB (PCR-positive), with liver, renal or cardiac diseases, those already on treatment for thyroid disorders or hyperprolactinemia or cases where abnormality was found in husband's semen analysis also were excluded from their study. Likewise, Rahaman et al 20 conducted a case control study in 30 infertile women and 30 fertile women in 2007 in Bangladesh excluding the women with organic lesion in uterus or ovary and with history of previous abdominal surgery. They reported the prevalence of thyroid disorder as 33.3% which was higher than the present study.…”

Section: Discussionmentioning

confidence: 99%

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Thyroid Profile in Infertile Women

Manandhar¹,

Manandhar²,

Sharma³

2018

Nepal Med Jor

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Introduction: Infertility is defined as inability to conceive after one year of regular unprotected intercourse. Thyroid disorders can lead to infertility arising from different pathophysiological mechanisms. The aim of this study is to determine the prevalence and type of thyroid disorder in infertile women and to compare the prevalence of thyroid disorder in primary and secondary infertility. Methods: A hospital-based descriptive cross-sectional study conducted in the Department of Obstetrics and Gynecology, Tribhuvan University Teaching Hospital, Kathmandu, Nepal from 1st Baishak 2068 to 30th Chaitra 2068 (14th April 2011 to 12th April 2012). Results: Among 156 infertile women enrolled and analyzed in the present study, thyroid disorder was found in 12 women giving the prevalence of thyroid disorder in infertile women as 7.7%. Hypothyroidism was more common comprising 6.4% of all infertile women, out of which subclinical hypothyroidism was 3.8% and clinical hypothyroidism was 2.6%. Hyperthyroidism was seen in 1.3% of all infertile women of which subclinical hyperthyroidism was 0.64% and clinical hyperthyroidism was 0.64%. Prevalence of thyroid disorder in primary infertility was 9.8% and in secondary infertility it was 3.7%. Among the 12 infertile women with thyroid disorder, four infertile women (33%) conceived. Three cases of hypothyroidism conceived after treatment and one case of subclinical hyperthyroidism conceived without any treatment. Conclusions: This study shows that thyroid dysfunction shows a significant role in infertility. Proper management of the thyroid dysfunction can result regain of fertility. Therefore, routine screening is required to all cases of infertility for possible thyroid disorders.

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Thyroid Profile in Infertile Women

Manandhar¹,

Manandhar²,

Sharma³

2018

Nepal Med Jor

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“…8,9 Binita et al found the prevalence to be 8% while Sharma et al found the prevalence to be 20%. 6,10 The prevalence of thyroid dysfunction in infertile women was found to be 33.3% in a study by Rahman et al and 23% by Sharma et al 11,12 In this study, thyroid dysfunction was present in 25.5% of the infertile women, where 23.5% had hypothyroidism and 2% had hyperthyroidism. It is obvious from the observation that fertility of female reproductive system is hampered by altered thyroid hormone levels.…”

Section: Discussionmentioning

confidence: 52%

“…7 Hyperprolactinemia which results from a longstanding primary hypothyroidism may result in ovulatory dysfunctions ranging from inadequate corpus luteal progesterone secretion to oligomenorrhoea or ammenorhoea. 11 Amenorrhoea occurs in hypothyroidism due to hyperprolactinaemia, which results from a defect in the positive feedback of oestrogen on LH, and because of the suppression of LH and FSH. 12 Thyroid dysfunction is implicated in a broad spectrum of reproductive disorders, ranging from abnormal sexual development to menstrual irregularities and infertility.…”

Section: Introductionmentioning

confidence: 99%

Analytical study of thyroid and prolactin hormone levels in infertile women with menstrual irregularities

Keerthanaa

Hiremath

2020

Int J Reprod Contracept Obstet Gynecol

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Though there are several factors plays role in the causing infertility, endocrine hormones play a crucial role in it. Among all the hormones, thyroid hormones have profound effects on reproduction and pregnancy. There are several experimental evidences, conducted both in animals and also in humans which proved that there is association of hyperthyroidism or hypothyroidism with ABSTRACT Background: Infertility is the inability of a couple to achieve pregnancy over an average period of one year (in a woman under 35 years of age) or 6 months (in a woman above 35 years of age) despite adequate, regular (3-4 times per week), unprotected sexual intercourse. It is of two types, primary infertility and secondary infertility. It can be due to the woman, the man, or both men and woman. Though there are several factors plays role in the causing infertility, endocrine hormones play a crucial role in it. Among all the hormones, thyroid and prolactin hormone have profound effects on reproduction and pregnancy. Methods: A prospective analytical study was conducted among 200 female patients, of age group 20-40 years, attending the outpatient department of obstetrics and gynecology. Sent for analysis of thyroid profile and prolactin levels. The data of the patients who have been completely followed up after six months was entered in excel sheet and analyzed using SPSS (version 16). Results: In this study the mean age of the study participants were 31.33±4.12 years and 4 of them were below 25 years of age. There is high prevalence of hypothyroidism (23.5%) and hyperprolactinemia (31%) was noted among the infertile females. Conclusions: The assessment of thyroid function and prolactin levels is mandatory in the work up of all infertile women, especially those presenting with menstrual irregularities. Also, early initiation of treatment may help in restoring the fertility among the infertile woman.

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“…3 It is anticipated that globally 60-80 million couples face the problem to conceive every year. 4 The prevalence of infertility in Pakistan has been estimated which is about 21.9%. 5 WHO (World Health Organization) has defined subfertility clinically as "Inability of a couple to achieve a pregnancy after 12 months (under 35 year of age) or within 6 months (above 35 year of age) of regular unprotected sexual intercourse".…”

Section: Introductionmentioning

confidence: 99%

Thyroid Disorders;

Rahman

Saeed

Zia

et al. 2019

TPMJ

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Infertility has been considered as a worldwide global health issue. It is a human nature that every couple wants to have children so that the relationship can become stronger. Defect in thyroid hormone levels is one of the factors which can lead to reproductive cycle disorders and thus infertility results. Objectives: The purpose of current study was to investigate the levels of thyroid hormones in primary infertile and fertile females in order to evaluate the prevalence of thyroid disordsers. Study Design: Case control study. Place of Study: Outdoor of gynecology department of Madinah Teaching Hospital, Faisalabad. Duration of Study: 6 months from July to December 2017. Material and Methods: The study enrolled total 91 females of reproductive age 20-35 years which included 45 primary infertile females and 46 fertile females. They were divided into two groups. Group I: case/primary infertile women group (n= 45) and Group II: control /fertile females group (n= 46). Data was collected by taking history and clinical examination. Hormonal profile including fT3, fT4 and TSH was done by means of chemiluminescentimmunoassay. Results were analyzed by using SPSS version 20. Results: Most of the infertile females were euthyroid and hyperthyroidism was the most common thyroid disorder. The prevalence of hypothyroidism and hyperthyroidism was about 9.3% and 26.7% respectively. The p-value showed the non-significant difference in the levels of fT3, fT4 and TSH between primary infertile and fertile females.Significant positive correlation between fT3 and fT4 while non-significant negative correlation was observed between fT3 & TSH and fT4& TSH in primary infertile females. Conclusion: Infertile females with menstrual irregularities should be advised thyroid profile in order to avoid other unnecessary investigations. Evaluation of thyroid status in the infertile couple is not only important but also easy because its treatment is very simple and often has revocable effects on subfertility.

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Thyroid disorders in female subfertility

Abstract: Key words: thyroid dysfunction; female subfertilitydoi: 10.3329/jcmcta.v19i2.3871Journal of Chittagong Medical College Teachers' Association 2008: 19(2):46-50

Cited by 14 publications

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Thyroid Profile in Infertile Women

Thyroid Profile in Infertile Women

Analytical study of thyroid and prolactin hormone levels in infertile women with menstrual irregularities

Thyroid Disorders;

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