Thyroid Profile in Infertile Women

Manandhar, Rojina; Manandhar, Bekha; Sharma, Jyoti

doi:10.37080/nmj.6

Cited by 4 publications

(13 citation statements)

References 8 publications

(13 reference statements)

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“…In the present study the mean (±SD) age of the participants was 27.7 (±4.2) years which was similar to other studies. 3,8,10 The mean age was significantly high in secondary infertility compared to primary infertility which can be expected due to its selection criteria and was comparable with other study. 11 Among the study population majority were having primary infertility (72.3%) than secondary infertility (27.7%), finding in common with other studies.…”

Section: Discussionsupporting

confidence: 85%

“…11 The prevalence of thyroid disorder among infertile women varies from 4.6% to 25.6% in different studies and in the current study it was 18.4%. 3,4,8,10 Hypothyroidism was the most common thyroid disorder (13.6%) the prevalence of which was similar to study conducted by sharma et al (17%). 14 However other studies have showed higher 6,7,9,10 as well as low prevalence3.…”

Section: Discussionsupporting

confidence: 80%

“…The sample size of 213 was calculated with 95% confidence interval taking 5% allowable error and 10% nonresponse rate, considering 7.7% prevalence of thyroid disorder among infertile women determined in previous study at same institute. 8 Women's records obtained from infertility OPD were reviewed. Detail clinical information such as age, menstrual cycles, type and duration of subfertility, history of thyroid disease, hyperprolactinemia or any medication use were noted.…”

Section: Methodsmentioning

confidence: 99%

“…3,6 It can cause anovulatory cycles, luteal phase defect, high serum prolactin (PRL) levels, and sex hormone imbalances leading to infertility. [4][5][6][7][8][9][10] Therefore, normal thyroid function is necessary for optimal fertility in order to achieve and sustain a healthy pregnancy. Elevated thyrotropin releasing hormone (TRH) levels in hypothyroidism are often associated with increased PRL levels.…”

Section: Introductionmentioning

confidence: 99%

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Thyroid Disorders and Prolactin Hormone and Their Association with Obesity in Infertile Women in a Tertiary Hospital of Nepal

Maskey

Rijal

2020

Journal of Institute of Medicine

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Introduction Thyroid dysfunction has profound effects on menstrual function and female fertility. Hypothyroidism is often associated with increased prolactin level which again worsens the problem. This study was done to evaluate the prevalence of thyroid disorders in infertile women attending infertility outpatient department (OPD) in Tribhuvan University Teaching Hospital (TUTH) and to determine the association of hypothyroidism and hyperprolactenemia with obesity which is not well studied in our population. MethodsA hospital-based cross-sectional study was conducted in infertility OPD of TUTH reviewing women’s records who underwent infertility workup and relevant history, clinical finding and results of investigations including thyroid function test (TFT) and serum prolactin (PRL) level were documented. Descriptive and inferential statistical analyses were used to identify the prevalence and associations of predictors and outcome variables. ResultsOut of 213 participants, the majority of the participants were obese (90; 42.3%) with mean (±SD) body mass index (BMI) being 24.8 ± 4.5 kg/m2. The prevalence of thyroid disorder was 18.4% including hypothyroidism 13.6% and hyperthyroidism 4.8%. There was no significant association of BMI and hyperprolactinemia with thyroid disorder as well as of BMI with hyperprolactinemia however the thyroid stimulating hormone (TSH) had significant positive correlation with prolactin (r=0.23, p<0.001). ConclusionThyroid disorders and hyperprolactinemia are commonly observed in infertile women, so they should be routinely screened during initial evaluation of infertility. As majority of the study population were obese, despite no significant association of BMI with thyroid disorder and hyperprolactinemia, the effect of weight gain on infertility cannot be overlooked.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionsupporting

confidence: 80%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Thyroid Disorders and Prolactin Hormone and Their Association with Obesity in Infertile Women in a Tertiary Hospital of Nepal

Maskey

Rijal

2020

Journal of Institute of Medicine

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“…3 There are limited articles related to aetiological factors of infertility published from Nepal and Dhulikhel Hospital (DH). [4][5][6][7][8][9][10][11][12] As there are adequate numbers of infertility cases being managed in DH, this descriptive cross-sectional…”

Section: Introductionmentioning

confidence: 99%

Study on probable aetiological factors of subfertility in a tertiary care hospital

Lamsal

Tamrakar

2022

J. Kathmandu Med. Coll.

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Background: Subfertility refers to describe women or couple who are not sterile but exhibit decreased reproductive efficiency even after 12 months of regular unprotected intercourse. Objectives: To find probable aetiological factors in subfertile couples attending Dhulikhel Hospital. Methods: This descriptive cross-sectional study was conducted among 140 subfertile couples in Dhulikhel Hospital from March 2016 to December 2017 after ethical clearance. The participants were recruited by convenience sampling, data were entered in Microsoft Excel Sheet and analysed using SPSS v.23. Descriptive statistics like frequency, percent, mean, and standard deviation have been presented. Results: Among 140 subfertile couples, mean duration of subfertility was 5.55 ± 3.96 years. About two-thirds (95, 67.9%) of them were of primary subfertility. Most subfertile clients (both) were of 26-30 years age group and about three-fifths (83, 59.3%) were of Janajati caste. The most common cause of subfertility was female factor (72, 51.4%) only. Ovulatory dysfunction (49, 35%) followed by tubal abnormalities (24, 17.1%) were major female contributory factors. Thyroid disorder was noted in 19 (13.6%) clients and hyperprolactinaemia was observed in 14 (10%) subfertile female clients. Two (1.4%) female clients had diabetes mellitus and 24 (17.1%) had evidence of different forms of genital infection. Only male factor contributed was seen in 16 (11.4%) clients and asthenozoopermia was the commonest abnormal semen parameters. Six (4.3%) males with abnormal semen parameter were working abroad. Conclusion: Ovulatory causes was found to be the commonest cause of subfertility in Dhulikhel Hospital. Asthenooospermia was the most common male factor.

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Community Development for Bote in Chitwan National Park, Nepal: A Political Ecology of Development Logic of Erasure

2023

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The conflict between development and conservation concerns is a perennial topic in sustainable development, and especially significant for marginalized social groups. In Nepal, fortress conservation in protected areas (PA) gave way to a community-based development and natural resource management (CBNRM) narrative of inclusion and participation in so-called buffer zone (BZ) initiatives around national parks. Studies to date show mixed outcomes of the community-based model for marginalized communities, especially for traditional indigenous river and forest dwellers. Academic and government reports of successes and failures of community-based projects in Nepal assume progress is based on traditional indigenous livelihood practices being abandoned and participation in state modernization initiatives in parks and reserves. Thus, despite promises of participation, evidence to date shows a de facto continuation of fortress conservation thinking and erasure of customary knowledge and livelihoods. Based on an ethnographic inquiry informed by political ecology conducted in two villages of Bote IPs (in the buffer zone area) of the Nawalparasi District of Chitwan National Park (CNP), we describe how state interventions and regulations under the guise of community-based participation actively ignore the moral ecology of traditional riverine livelihoods while pursuing a modernization project. Echoing calls by other scholars and stakeholders, we argue that a new approach to conservation and development that respects the environmental ethics of traditional livelihoods is long overdue in Nepal.

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Thyroid Profile in Infertile Women

Cited by 4 publications

References 8 publications

Thyroid Disorders and Prolactin Hormone and Their Association with Obesity in Infertile Women in a Tertiary Hospital of Nepal

Thyroid Disorders and Prolactin Hormone and Their Association with Obesity in Infertile Women in a Tertiary Hospital of Nepal

Study on probable aetiological factors of subfertility in a tertiary care hospital

Community Development for Bote in Chitwan National Park, Nepal: A Political Ecology of Development Logic of Erasure

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