Thyroid disorders in chronic hepatitis C

Antonelli, Alessandro; Ferri, Clodoveo; Pampana, Alessandro; Fallahi, Poupak; Nesti, Claudia; Pasquini, Martina; Marchi, Santino; Ferrannini, Ele

doi:10.1016/j.amjmed.2004.01.023

Cited by 202 publications

(181 citation statements)

References 20 publications

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“…TGAb was determined in 8 studies [7,17,18,[20][21][22][23]25]. The pooled OR was 2.40 (95%CI 1.85-3.13), suggesting that TGAb was more prevalent in HCV group.…”

Section: Association Of Hcv Infection With the Prevalence Of Anti-thymentioning

confidence: 99%

“…Among the 12 studies, hypothyroidism was reported in 11 [7,[15][16][17][18][19][20][21][22][23][24], while hyperthyroidism in 5 studies [16,20,21,23,24]. TGAb was covered in 8 studies [7,15,17,18,[20][21][22][23], TPOAb in 6 studies [16,17,[20][21][22][23] and ATMA in 5 studies [6,7,15,19,22].…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…Study characteristics are shown in Table I. The design of these studies was cross-sectional [17,22], case-control [7,16,[19][20][21]23] or cohort (prospective control) [6,18,24,25]. A total of 1,735 HCV-infected and 1,868 non-HCV infected subjects were involved.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…TGAb was covered in 8 studies [7,15,17,18,[20][21][22][23], TPOAb in 6 studies [16,17,[20][21][22][23] and ATMA in 5 studies [6,7,15,19,22].…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

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Thyroid Disturbance in Patients with Chronic Hepatitis C Infection: A Systematic Review and Meta-analysis

Shen

Wang

Xie

et al. 2016

JGLD

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Background & Aims: The involvement of thyroid autoimmunity and dysfunction in patients with chronichepatitis C virus (HCV) infection before interferon-α (IFN-α) therapy remains controversial. We performedthis meta-analysis to evaluate the association of HCV infection with the presence of anti-thyroid antibodiesand dysthyroidism. Methods: A literature search was carried out to collect articles dated up to August 2015 to identify observationalstudies which compared the prevalence of anti-thyroid antibodies and thyroid dysfunction in IFN-α naïvechronic HCV-infected subjects with non-HCV infected controls. Random-effect or fixed-effect meta-analyseswere applied and results reported as odds ratios (ORs) with 95% confidence intervals (CIs). Results: Twelve studies were included, involving 1,735 HCV-infected and 1,868 non-HCV infected subjects.Pooled anti-thyroid antibody prevalence tended to be higher in HCV-infected subjects. The prevalence ofanti-thyroglobulin antibody (TGAb), anti-thyroid peroxidase antibody (TPOAb), anti-thyroid microsomalantibody (ATMA) were 2.40-fold, 1.96-fold and 1.86-fold higher in HCV-infected subjects than in controls,respectively. The prevalence of hypothyroidism also differed by HCV infection status, with a pooled risk of3.10 (95%CI: 2.19-4.40) in HCV-infected subjects. However, the results did not show a significant differencein the prevalence of hyperthyroidism between the two groups.Conclusion: Chronic HCV infection may be an independent risk factor for thyroid disturbance. It is advisablefor the clinicians to monitor both thyroid antibodies and function in the course of chronic HCV infection,independent of IFN-α treatment. Abbreviations: AITD: autoimmune thyroid disease; ATMA: anti-thyroid microsomal antibody; CHC:chronic hepatitis; GD: Graves’ disease; HCV: hepatitis C virus; HT: Hashimoto’s thyroiditis; IFN-α: interferonalpha;NOS: Newcastle-Ottawa quality assessment scale; T3: triiodothyronine; T4: thyroxine; TGAb: antithyroglobulinantibody; TPOAb: anti-thyroid peroxidase antibody.

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“…TGAb was determined in 8 studies [7,17,18,[20][21][22][23]25]. The pooled OR was 2.40 (95%CI 1.85-3.13), suggesting that TGAb was more prevalent in HCV group.…”

Section: Association Of Hcv Infection With the Prevalence Of Anti-thymentioning

confidence: 99%

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…TGAb was covered in 8 studies [7,15,17,18,[20][21][22][23], TPOAb in 6 studies [16,17,[20][21][22][23] and ATMA in 5 studies [6,7,15,19,22].…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

See 2 more Smart Citations

Thyroid Disturbance in Patients with Chronic Hepatitis C Infection: A Systematic Review and Meta-analysis

Shen

Wang

Xie

et al. 2016

JGLD

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“…Autoimmune thyroid disease HCV infection is associated with a high prevalence of thyroid autoantibodies, but only a proportion of these patients also show thyroid dysfunction [78].…”

Section: T-cell-triggered Autoimmune Diseases During Hcv Infectionmentioning

confidence: 99%

Hepatitis C virus and autoimmunity

Böckle

Sepp

2010

Autoimmun Highlights

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Hepatitis C virus infection is associated with several extrahepatic manifestations. About 60% of patients infected with HCV develop at least one extrahepatic manifestation. The majority of these diseases seem to be triggered through autoimmune mechanisms, such as autoantibody production, autoreactive T cells and complex autoimmune mechanisms leading to systemic autoimmune disorders. In this review we categorize these diseases into three groups according to the main pathogenetic process involved, in particular B-cell-mediated, T-cell-mediated and complex autoimmune systemic diseases.

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