Thyroid disorders and inflammatory bowel diseases: Retrospective evaluation of 909 patients from an Italian Referral Center

Cesarini, Monica; Angelucci, E.; Rivera, M.; Pica, Roberta; Paoluzi, P.; Vernia, Piero; Corazziari, E.

doi:10.1002/ibd.20964

Cited by 12 publications

(9 citation statements)

References 6 publications

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“…Treatmentrefractory colitis in the context of inflammatory bowel disease and hyperthyroidism has been described; remission was achieved once anti-thyroid medications were commenced [49]. These findings are consistent with another study that reported doubling of the risk of thyroid disease in patients with inflammatory bowel disease compared with healthy western populations [50].…”

Section: Inflammatory Bowel Diseasesupporting

confidence: 69%

Thyroid disorders and gastrointestinal and liver dysfunction: A state of the art review

Kyriacou

McLaughlin

Syed

2015

European Journal of Internal Medicine

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Section: Inflammatory Bowel Diseasesupporting

confidence: 69%

Thyroid disorders and gastrointestinal and liver dysfunction: A state of the art review

Kyriacou

McLaughlin

Syed

2015

European Journal of Internal Medicine

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“…In this study Hashimoto thyroidis rates are reported as 1.98% in all IBD patients, 2.15% in CD patients and 1.8% in UC patients. As a result of this study it has been concluded that thyroid disorder rate is twice in IBD patients than that in healthy European population [3]. Subclinical hyperthyroidism also has been reported in patients with in ulcerative colitis [11].…”

Section: Discussionmentioning

confidence: 58%

“…Ulcerative colitis and CD are associated with a wide range of extraintestinal complications that influence the course and therapy of the disease. Although extrain-testinal complications of IBD including rheumatologic, ocular, dermatologic and hepatobiliary complications are well understood, the data regarding the relationship between IBD and thyroid disorders are not completely established [1][2][3]. Epidemiological investigations showed an increased prevalence of hyperthyroidism and IBD.…”

Section: Introductionmentioning

confidence: 99%

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Thyroid Disorders in Patients with Inflammatory Bowel Diseases

Yakut¹,

Üstün²,

Kabacan³

et al. 2011

IJCM

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Background: The rate of thyroid disorders is reported to be increased in patients with Ulcerative Colitis (UC) and Crohn’s disease (CD) than the normal population. The purpose of this study is to evaluate the prevalance of Thyroid disorders in a group of patients with inflammatory bowel diseases (IBD). Material and Methods: 146 IBD patients (113 UC and 33 CD patients) and 66 healthy control subjects were enrolled into the study. Serum free T4 (FT4), free T3 (FT3), TSH and anti TPO levels of the patients were analyzed retrospectively and and compared with a control group. These cases were also investigated with thyroid ultrasound and nuclear (scintigraphy) imaging. Results: The mean age of IBD patients (76 women) was 42.9 ± 12.4 years. Among the control group 42 were female and their mean age was 40.9 ± 12.1 years. Thyroid gland disease was found in 14 (9.5%, 8 female, 6 male) of 146 IBD patients. The frequency of thyroid disorders has been found to be higher than the control group in patients with control group (14/146 vs. 1/66, p = 0.042). No statistically significant difference has been observed at the thyroid disorder rates between the UC and CD patients (11/113 vs. 3/33, p = 0.912). Hashimoto thyroiditis has been found at 4 (2.7%) of the IBD patients. Conclusion: In accordance with several works published in literature, we have found a higher rate of thyroid disease apperance at IBD patients

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“… 15 Recent experimental studies have indicated that LT3S is associated with inflammation and nutritional status. 3 , 16 What is more, previous studies have recognized the association of LT3S and chronic inflammatory diseases, such as inflammatory bowel disease, 17 , 18 and raised the possibility that inflammatory cytokines may be predisposing factors for LT3S. 19 Based on these aspects, we hypothesize that LT3S might be associated with RE.…”

Section: Introductionmentioning

confidence: 85%

Low Triiodothyronine Syndrome in Patients With Radiation Enteritis

Fan

Wang

et al. 2016

Medicine

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The implications of low triiodothyronine syndrome (LT3S) in patients with radiation enteritis (RE) have not been properly investigated. As such, we conducted this cohort study to investigate the association between LT3S and RE, to explore the etiology of LT3S in RE, to evaluate the clinical features and clinical outcomes of LT3S patients, and to inspect the correlation of clinical variables and LT3S in RE.This prospective study included 39 RE patients. Medical records and various laboratory parameters (including thyroidal, tumorous, nutritional, and radiotherapy variables) were collected in all participants.Our results showed that the incidence of LT3S was 84.6% in patients with RE. Total protein (71.7 ± 5.7 vs 63.2 ± 9.6 g/L, P = 0.04) and albumin (ALB, 46.0 ± 4.6 vs 38.7 ± 5.3 g/L, P = 0.01) were significantly lower in LT3S group compared with those in euthyroid group. Standard thyroid-stimulating hormone index (−0.89 ± 2.11 vs −2.39 ± 1.33, P = 0.03) and sum activity of deiodinases (19.74 ± 4.19 vs 12.55 ± 4.32 nmol/L, P = 0.01) were significantly lower in LT3S group. Patients with LT3S suffered longer duration of hospitalization (48.25 ± 23.29 days in LT3S vs 26.75 ± 10.56 days in euthyroid, P = 0.036). Low serum ALB (β = 0.694, 95% CI = 0.007–0.190, P = 0.037) was the only significant predictor of LT3S.LT3S was common in RE patients. A hypodeiodination condition and a potential pituitary-thyrotroph dysfunction might play a role in the pathophysiology of LT3S in RE. Worse nutritional status and clinical outcomes were confirmed in RE patients with LT3S. Furthermore, total protein and ALB were observed as protective and differentiating parameters of LT3S in RE. In summary, this was the 1st investigation to evaluate the clinical correlation between RE and LT3S, investigate the prevalence of LT3S in RE, and explore the pathogenesis of LT3S, despite the limitation of a relatively small sample size. These results will hopefully encourage future research to place greater emphasis on early identification of LT3S in RE patients.

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Thyroid disorders and inflammatory bowel diseases: Retrospective evaluation of 909 patients from an Italian Referral Center

Cited by 12 publications

References 6 publications

Thyroid disorders and gastrointestinal and liver dysfunction: A state of the art review

Thyroid disorders and gastrointestinal and liver dysfunction: A state of the art review

Thyroid Disorders in Patients with Inflammatory Bowel Diseases

Low Triiodothyronine Syndrome in Patients With Radiation Enteritis

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