Thyroid Cryotherapy in an Experimental Rat Model

Pomorski, Lech; Bartos, M; M, Matejkowska; Amsolik, Maciej; Kuzdak, Krzysztof

doi:10.1006/cryo.1999.2209

Cited by 6 publications

(3 citation statements)

References 29 publications

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“…Pomoski et al used nitrous oxide-cooled apparatus to freeze the thyroid gland in rats [161]. In two weeks, necrosis and granulomatous inflammation were still present, but in four weeks after freezing, only lymphocytic infiltration and fibrosis were observed in the atrophic gland.…”

Section: Diverse Tissuementioning

confidence: 99%

Experimental cryosurgery investigations in vivo

2009

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Cryosurgery is the use of freezing temperatures to elicit an ablative response in a targeted tissue. This review provides a global overview of experimentation in vivo which has been the basis of advancement of this widely applied therapeutic option. The cellular and tissue-related events that underlie the mechanisms of destruction, including direct cell injury (cryolysis), vascular stasis, apoptosis and necrosis, are described and are related to the optimal methods of technique of freezing to achieve efficacious therapy. In vivo experiments with major organs, including wound healing, the putative immunological response following thawing, and the use of cryoadjunctive strategies to enhance cancer cell sensitivity to freezing, are described.

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Section: Diverse Tissuementioning

confidence: 99%

Experimental cryosurgery investigations in vivo

2009

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“…Therefore, well‐known non‐operative treatments such as levothyroxine (5) and 131 I therapy (6, 7) are being used more and more frequently and in addition new methods are being developed (8, 9). Newly proposed modalities can be divided into two major groups: those with thermal effects, such as thyroid cryotherapy (10, 11) and hyperthermia (12), and those using various chemical agents.…”

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confidence: 99%

Histologic changes in thyroid nodules after percutaneous ethanol injection in patients subsequently operated on due to new focal thyroid lesions

Pomorski

Bartos

2002

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This paper reports macro- and microscopic changes in hyperfunctioning thyroid nodules (HTN), initially diagnosed as solitary, in patients treated with percutaneous ethanol injection (PEI). In 78 patients, benign solitary HTN were diagnosed by clinical and hormonal examination. High resolution ultrasonography confirmed the solitary nodule. The results of fine needle aspiration biopsy (FNAB), performed twice, ruled out malignancy of the nodule. The patients were referred for PEI treatment. At 1-year follow-up, newly formed thyroid nodules, whose volumes increased, were detected in five patients (6.4%) with HTN, initially diagnosed as solitary. Therefore, these patients were operated on. Subtotal thyroidectomy was performed. At the intraoperative macroscopic evaluation, a hard fibrous solid mass was found in place of three nodules (n1, n2, n3) following PEI treatment. The middle area of the cut surface of PEI-treated nodules (n4 and n5) in the other two patients was firm and haemorrhagic, surrounded by a fibrous mass. Histolopathologic examination of n1, n2 and n3 revealed fibrosis and hyalinosis. Examination of n4 and n5 showed haemorrhagic necrosis in the middle of the nodules surrounded by fibrous tissue.

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“…By the end of week two, the highest weight gain was observed in group 4 (cryosurgery). Although few studies have objectively evaluated the effects of cryosurgery in the upper aerodigestive tract, several authors 13,14,16 have reported minimal pain after liquid nitrogen cryosurgery.…”

Section: Discussionmentioning

confidence: 99%