Thyroid cartilage involvement in patient affected by IgA multiple myeloma: Case report

Abstract

Neoplasms originating from plasma cell are rare in the head and neck region. A correct clinical evaluation is very important in order to formulate a differential diagnosis as well as to distinguish local from metastatic disease. We report a case of larynx involvement by an IgA multiple myeloma in a 69-year-old female diagnosed in October 2004 and treated with chemotherapy; the 1 year control do not show progression of disease and the laryngeal lesion is unchanged. We highlight the radiological findings and clinical features to suspect plasma cell tumors in cases with a similar presentation. #

Myeloma of Laryngeal Cartilage: Literature Review and Case Study

“…14 Since then, multiple radiological images characterized by thin and expanded cartilage lamina of laryngeal cartilage have also suggested a primary mass originating within the cartilage. 11,13,21 However, there have not been any further cases with histological confirmation of osseous metaplasia with myelomatous involvement. This may again be due to the rarity of these conditions or due to biopsies of insufficient depths that miss the osseous metaplasia center within the cartilage.…”

“…There was only one female reported among the cases analyzed. 11 Myeloma of laryngeal cartilages were more commonly encountered as a manifestation of MM (81%) as shown in Table 3. This could be due to the presence of systemic symptoms in MM that warrant more comprehensive investigation, thus increasing likelihood of detection compared to EMP.…”

“…Where reported, mucosa overlying the mass was always normal in appearance. 5,[10][11][12]17 Additionally, ipsilateral vocal cord edema and palsy were also observed in some cases 4,7,9,20 Thus far in the literature, there have been no reports of lymph node involvement in MLC. In one case, 23 a possible malignant involvement of lymph nodes was suspected on CT; however, this was excluded on further investigation.…”

“…Computed tomography, with or without contrast, used to evaluate local extensions identified lowdensity masses 18,21 varying in size from 2 cm to 5 cm. 12,[17][18][19][20] They were often characterized by thin expansion of cortical cartilage 5,11,13,17,21 with presence of small punctate calcifications. 12,13,22 In some cases, invasion of adjacent structures were also observed.…”

“…This article presents a review of 16 known MLC cases from 15 published articles 5,[10][11][12][13][14][15][16][17][18][19][20][21][22][23] (Table 1) and one case from institutional records. Since patient management, as well as prognosis, vary widely depending on different PCN entities, accurate diagnosis is vital for optimal management.…”