Thyroid Cancer: We Need a Carcinogen-specific Genome Study

Bae, Jong-Myon

doi:10.3346/jkms.2015.30.12.1920

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Radiation- Epigenetic Alteration – (Thyroid) Cancer Occurren1

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2018

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“…The number of cases for the RET/PTC chromosomal rearrangement increased as the level of radiation exposure increased [ 10 , 12 ]. Based on these findings, it would be possible to infer a specific carcinogenesis for each cases of cancer by examining the pattern of genetic changes [ 13 ].…”

Section: Radiation- Epigenetic Alteration – (Thyroid) Cancer Occurrenmentioning

confidence: 99%

Researches of Epigenetic Epidemiology for Infections and Radiation as Carcinogen

Bae

2018

J Prev Med Public Health

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In recent years, a number of studies have been reported on the various types of cancer arising from epigenetic alterations, including reports that these epigenetic alterations occur as a result of radiation exposure or infection. Thyroid cancer and breast cancer, in particular, have high cancer burden, and it has been confirmed that radiation exposure or onco-viral infection are linked to increased risk of development of these two types of cancer, respectively. Thus, the environment-epigenetic alteration-cancer occurrence (EEC) hypothesis has been suggested. This paper reviews the trends in research supporting this hypothesis for radiation exposure and onco-viral infection. If more evidences accumulate for the EEC hypothesis from future research, those findings may greatly aid in the prevention, early diagnosis, treatment, and prognosis of the thyroid cancer and breast cancer.

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Section: Radiation- Epigenetic Alteration – (Thyroid) Cancer Occurrenmentioning

confidence: 99%