Thyroid autoantibodies in pregnancy are associated with hypertensive disorders of pregnancy: Ma'anshan Birth Cohort Study

Yan, Han; Mao, Leijing; Ge, Xing; Huang, Kun; Yan, Shuangqin; Ren, Lingling; Hong, Shikai; Gao, Hui; Sheng, Jie; Xu, Yuanyuan; Pan, Weijun; Zhu, Peng; Hao, Jiahu; Zhu, Dawei; Tao, Fangbiao

doi:10.1111/cen.13590

Cited by 12 publications

(13 citation statements)

References 38 publications

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“…One study found that the abnormal elevation of titers of both TPOAbs and TgAbs in the first trimester of pregnancy were linked to an increase in morbidity due to hypertensive disorders of pregnancy, which was mainly caused by an increased risk of gestational hypertension, and the complications had no relationship with thyroid function. However, an association between the abnormal elevation of TgAbs and the risk of gestational hypertension or preeclampsia in the second trimester was not found [ 92 ]. Their results have been supported by another study that included 5805 women from 12 to 20 weeks of gestation, and the study did not find an association between abnormal elevations of thyroid antibodies (TPOAbs or TgAbs) and preeclampsia [ 93 ].…”

Section: Clinical Significance Of Trabs Tpoabs and Tgabsmentioning

confidence: 99%

“…The variation of TPOAbs and TgAbs over time are similar to those of TRAbs. Many researchers have observed that serum levels of TPOAbs and TgAbs gradually decrease during pregnancy but rebound after delivery [ 92 , 113 – 116 ]. Their findings are the same as those we observed in the patients in Ruijin hospital (Figures 2 and 3 ).…”

Section: The Variation In Trabs Tpoabs and Tgabs During And Aftementioning

confidence: 99%

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The Clinical Value and Variation of Antithyroid Antibodies during Pregnancy

Zhou

Huang

et al. 2020

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Antithyroid antibodies, which include thyroid-stimulating hormone receptor antibodies (TRAbs), thyroid peroxidase antibodies (TPOAbs), and thyroid globulin antibodies (TgAbs), are widely known for their tight association with thyroid autoimmune diseases. The variation in all three kinds of antibodies also showed different trends during and after pregnancy (Weetman, 2010). This article reviewed the the physiological changes, while focusing on the variation of thyroid antibodies concentration in women during and after pregnancy, and adverse consequences related to their elevation. Since abnormal elevations of these antithyroid antibodies may lead to adverse outcomes in both mothers and fetuses, special attention must be paid to the titer of the antibodies during pregnancy. The molecular mechanisms of the variations in those antibodies have yet to be explained. The frequency and timing of thyroid antibody measurement, as well as different reference levels, also remain to be elucidated.

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Section: Clinical Significance Of Trabs Tpoabs and Tgabsmentioning

confidence: 99%

Section: The Variation In Trabs Tpoabs and Tgabs During And Aftementioning

confidence: 99%

The Clinical Value and Variation of Antithyroid Antibodies during Pregnancy

Zhou

Huang

et al. 2020

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“…1 Several studies have shown that thyroid dysfunction is associated with hypertensive disorders during pregnancy. [2][3][4] Hypertensive disorders of pregnancy include chronic hypertension, gestational hypertension (GH), preeclampsia, and eclampsia, with an estimated prevalence of 4% to 11% among pregnant women in China. 5,6 GH is a major cause of maternal and infant morbidity and mortality.…”

Section: Introductionmentioning

confidence: 99%

Association between thyroid hormone parameters during early pregnancy and gestational hypertension: a prospective cohort study

2020

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Objective: Thyroid dysfunction may play a role in the development of gestational hypertension. However, this relationship remains unclear. This study was performed to evaluate the association between thyroid hormone parameters during early pregnancy and gestational hypertension. Methods: Women with singleton pregnancies were recruited into this prospective cohort study at 9 to 13 gestational weeks, and their serum thyroid-stimulating hormone, free thyroxine, and free triiodothyronine concentrations were measured using electrochemiluminescence immunoassays. In total, 1226 participants were included in the final analysis. Results: Of the 1226 participants, 81 subsequently developed gestational hypertension (overall incidence of 6.6%). Compared with women with euthyroidism, both pregnant women with hypothyroidism and those with subclinical hypothyroidism had an increased risk of gestational hypertension (adjusted odds ratio [OR], 3.61; 95% confidence interval [CI], 1.52-8.57 and OR, 2.24; 95% CI, 1.06-4.72, respectively). When the thyroid-stimulating hormone and free thyroxine concentrations were analyzed by quintiles, the women in the highest thyroid-stimulating hormone quintile had a higher risk of gestational hypertension (adjusted OR, 4.22; 95% CI, 1.78-9.05) than the women in the middle quintile. Conclusion: Our results suggest that hypothyroidism, subclinical hypothyroidism, and a high thyroid-stimulating hormone concentration during early pregnancy are risk factors for gestational hypertension.

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“…Previous researchers have shown that the levels of many different antibodies, including TgAbs, TPOAbs and TRAbs, may decrease during pregnancy and rebound after delivery. 4,[18][19][20][21][22] Regarding TgAbs, the study by Tamaki showed that the average TgAb level of 9 pregnant women in T2 was significantly lower than that in T1 (P<0.01), and The time point of conception respectively. Six weeks postpartum, the TgAb-positive rate of the pregnant group did not change compared with that in the third trimester (0%).…”

Section: Discussionmentioning

confidence: 99%

“…4,[14][15][16] In addition to variations in TRAbs, variations in both TPOAbs and TgAbs have been reported. 3,17,18 However, to date, no study has included all antibody types. In our study, we explored variations in the three antibody types during pregnancy and after delivery.…”

Section: Introductionmentioning

confidence: 99%

Variations in the Antithyroid Antibody Titre During Pregnancy and After Delivery

Li¹,

Zhang²,

Zhou³

et al. 2021

RMHP

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Thyroid autoantibodies in pregnancy are associated with hypertensive disorders of pregnancy: Ma'anshan Birth Cohort Study

Abstract: Our results show that TPOAb positivity and TgAb positivity in the first trimester are associated with an increased risk of HDP. These data demonstrate that these associations are even seen among euthyroid women.

Cited by 12 publications

References 38 publications

The Clinical Value and Variation of Antithyroid Antibodies during Pregnancy

The Clinical Value and Variation of Antithyroid Antibodies during Pregnancy

Association between thyroid hormone parameters during early pregnancy and gestational hypertension: a prospective cohort study

Variations in the Antithyroid Antibody Titre During Pregnancy and After Delivery

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