Thyroid associated components in serum during normal pregnancy

Skjöldebrand, Lottie; Brundin, Jan; Carlström, Anders; Pettersson, Tom

doi:10.1530/acta.0.1000504

Cited by 63 publications

(37 citation statements)

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“…During normal pregnancy, there is an overall increase in thyroid-related activity including a two-to three-fold increase in TBG concentrations, sharp increases in TT4 and TT3 concentrations early in pregnancy, an increase in serum thyroglobulin and an increase in renal iodide clearance [22]. The normal increases in TT4 plateau early in the second trimester at approximately 50% greater concentrations than pre-pregnancy values, often outside the normal nonpregnant reference interval.…”

Section: Discussionmentioning

confidence: 99%

Trimester-specific reference intervals for thyroxine and triiodothyronine in pregnancy in iodine-sufficient women using isotope dilution tandem mass spectrometry and immunoassays

Soldin

Hilakivi‐Clarke

Weiderpass

et al. 2004

Clinica Chimica Acta

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Background-Accurate assessment of the pregnant woman's thyroid status is critical, for both the initiation of thyroid hormone therapy and for the adjustment of thyroid hormone dose in those already receiving thyroid hormone. Trimester-specific intervals are especially important during pregnancy when thyroid insufficiency may be associated with adverse obstetric outcome and fetal neurodevelopmental deficits. We defined pregnancy-specific reference intervals for thyroxine (T4) and 3,5,3′-triiodothyronine (T3). We used a novel isotope dilution tandem mass spectrometry (LC/MS/MS) method, and compare these to reference intervals obtained by immunoassays (IAs) performed on the same samples.Methods-Concentrations of circulating T4 and T3 were measured simultaneously during first, second and third trimesters and postpartum in iodine-sufficient, healthy, singleton pregnancies using API-3000 LC/MS/MS with deuterium-labeled internal standard (L-thyroxine-d 2 ). Immunoassays were conducted on the same samples (T4 Dade Behring RxL, T3 DPCImmunolite).Results-Linear regression is reported for method comparisons; for T4, the slope decreased from r=0.900 in nonpregnant women to 0.802-0.820 during pregnancy. For T3, correlations between LC/MS/MS and immunoassays were weaker in all cases (r=0.407-0.574).Conclusion-In this longitudinal study, we established trimester-specific reference intervals for T4 and T3 by LC/MS/MS and compare these to intervals obtained by immunoassays.

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Section: Discussionmentioning

confidence: 99%

Trimester-specific reference intervals for thyroxine and triiodothyronine in pregnancy in iodine-sufficient women using isotope dilution tandem mass spectrometry and immunoassays

Soldin

Hilakivi‐Clarke

Weiderpass

et al. 2004

Clinica Chimica Acta

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“…For example, it is well known that T3 and T4 steadily increase during the first trimester and remain at high levels thereafter (Chan et al, 1975;Yamamoto et al, 1979;Skjoldebrand et al, 1982).…”

Section: Discussionmentioning

confidence: 99%

Serum thyroglobulin concentration in normal pregnancy.

et al. 1984

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We measured the levels of serum thyroglobulin (Tg) in 52 pregnant females at various stages and compared them with those of 15 age-matched nonpregnant females. Serum Tg was measured by a solid-phase immunoradiometric assay. In pregnant females, mean serum Tg levels at the first, second, early third, and late third trimesters were 8.4 (range; 1.3-18.0), 9.2 (1.7-25.6), 10.1 (1.8-22.8), and 12.1ng/ml (5.3-25.2), respectively. The statistical comparison was made after logarithmic transformation of the data. The mean value only at the late third trimester was significantly higher than that of controls (mean; 6.0ng/ml, range; 1.5-23.6), but each value was within the normal range. Although serum Tg levels have been reported to be high at the end of pregnancy, our results indicate that the Tg levels in females could be clinically interpreted without regard to the coexistence of pregnancy.

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“…There are many reports arguing the reason o f antibodies stimulate the maternal thyroid and inducing the elevated of T4 and T3 during pregnancy are partly due to thyroid abnormalities afterward. direct effect of elevation of TBG in maternal blood (Golinor, 1997;Skjoldebrand et al, 1982;Guillamue et al, HYPERTHYROIDISM AND HYPOTHYROIDISM 1985; Glinoer et al, 1990).…”

Section: Introductionmentioning

confidence: 99%

Thyroid Function Tests During First-trimester of Pregnancy: A Review of Literature

Mansourian¹

2010

Pakistan J. of Biological Sciences

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This literature review was conducted to summarize the main points of maternal thyroid function tests, with particular attention in the first trimester of pregnancy which accompanied with significant biochemical and metabolic alteration. The evaluation of thyroid function of either hyperthyroidism and hypothyroidism should be assessed by determination of serum Thyroid Stimulating Hormone (TSH), Thyroxine (T4), Triiodothyronine (T3), Iodine and Thyroid Autoantibodies. Glomerular filtration rate is increased during pregnancy; therefor iodine deficiency should be evaluated during the pregnancy to prevent hypothyroidism. The role which can be played by Human Chronic Gonadotropin (hCG) on stimulating the thyroid gland to become over-active was investigated. Serum level of thyroglobulin (Tg) and Thyroxin Binding Globulin (TBG) should be assessed for proper assessments of thyroid gland during pregnancy. Thyroid function tests during first-trimester of pregnancy and particularly the reference interval for thyroid function tests for pregnant women in each region has to be established, to prevent mis-diagnosis and irreversible mental and physical adverse affect for growing fetus.

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Thyroid associated components in serum during normal pregnancy

Cited by 63 publications

References 0 publications

Trimester-specific reference intervals for thyroxine and triiodothyronine in pregnancy in iodine-sufficient women using isotope dilution tandem mass spectrometry and immunoassays

Trimester-specific reference intervals for thyroxine and triiodothyronine in pregnancy in iodine-sufficient women using isotope dilution tandem mass spectrometry and immunoassays

Serum thyroglobulin concentration in normal pregnancy.

Thyroid Function Tests During First-trimester of Pregnancy: A Review of Literature

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