Thyroid Activity and Cold Adaptability

Suzuki, Mitsuo

doi:10.1007/978-3-642-93010-2_13

Cited by 8 publications

(5 citation statements)

References 83 publications

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“…This idea is supported by the observations of Reichlin et al (1972) and Suzuki (1972) who demonstrated an increase in TSH concentration following exposure to cold in man. The location of the receptors responsible for controlling the secretion of thyroxine in relation to ambient temperature has not yet been fully determined, but in the pig it is likely that those in the peripheral regions of the nervous system are most important.…”

Section: Discussionsupporting

confidence: 78%

“…Anderson, Brook & Ekman (1965) found that local cooling of the hypothalamus increased the protein bound S. E. EVANS AND D. L. INGRAM iodide in the plasma. More recently, exposure of subjects to reduced ambient temperatures was shown to increase the TSH level in the plasma (Suzuki, 1972;Reichlin, Martin, Mitnick, Boshans, Grimm, Bollinger, Gordon & Malacara, 1972).…”

Section: Introductionmentioning

confidence: 99%

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The effect of ambient temperature upon the secretion of thyroxine in the young pig.

Evans¹,

Ingram²

1977

The Journal of Physiology

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SUMMARY1. Fluctuations in the rate of secretion and metabolism of thyroxine in the pig were observed whilst the ambient temperature was reduced from 32 to 80 C. The quantity of food supplied was either maintained constant or doubled when the animals were exposed to the lower temperature.2. It was found that the rate of disappearance of [1251]thvroxine did not change when the animal was exposed to the cold, unless the animal's food intake was altered.3. The secretion of thyroxine increased temporarily after exposure to the cold. This was shown by a rise in the concentration of thyroxine in the plasma and a simultaneously increased loss of 1311 from the thyroid gland. The increase in secretion of thyroxine was not maintained throughout the exposure to cold when the food intake of the animal was kept constant.

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Section: Discussionsupporting

confidence: 78%

Section: Introductionmentioning

confidence: 99%

The effect of ambient temperature upon the secretion of thyroxine in the young pig.

Evans¹,

Ingram²

1977

The Journal of Physiology

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“…Histological changes occur in the thyroid gland within 1 h of the change in ambient temperature (Kajihara, Onaya, Yamada, Takemura & Kotani, 1972), and the level of TSH in the plasma increases (Suzuki, 1972;Reichlin, Martin, Mitnick, Boshans, Grimm, Bollinger, Gordon & Malacara, 1972). The present study, however, was concerned with the extent to which the increased activity of 435 D. L. INGRAM AND H. KACIUBA-USCILKO the thyroid gland is maintained over a period of between 4-7 d after the change in ambient temperature.…”

Section: Discussionmentioning

confidence: 99%

The influence of food intake and ambient temperature on the rate of thyroxine utilization.

Ingram¹,

Kaciuba-Uściłko²

1977

The Journal of Physiology

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SUMMARYYoung growing pigs of both sexes were subjected to changes in (1) energy intake, (2) ambient temperature, and (3) bulk of food. The rate of disappearance of injected 125I-labelled thyroxine from the plasma (K) was measured. An analysis of variance revealed that the effect attributable to changes in the energy content of the food intake was statistically significant (P < 0.01). A change in ambient temperature had no statistically significant effect on K, nor did a change in the bulk of food when energy intake was constant (P > 0.05).

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“…When animals are exposed to a cold environment, or the hypothalamic region of the brain is cooled, the thyroid gland is stimulated via an increase in thyroid releasing hormone (TRH) and thyroid stimulating hormone (TSH) (Suzuki, 1972;Reichlin, Martin, Mitnich, Boshans, Grimm, Bollinger, Gorden & Malacara, 1972;Evans & Ingram, 1974). The rates of metabolism of thyroid hormones and their plasma concentrations are also modified by the animal's energy supply, and the time since the last meal in pigs (Ingram & Dauncey, 1980;Ingram & Ramsden, 1981;Dauncey, Ramsden, Kapadi, Macari & Ingram, 1983b) and by food deprivation in man (O'Brien, Bybee, Burman, Osburne, Ksaizek, Wartofsky & Georges, 1980;Utiger, 1982).…”

Section: Introductionmentioning

confidence: 99%

Thyroid Hormone Nuclear Receptors in Skeletal Muscle as Influenced by Environmental Temperature and Energy Intake

Dauncey¹,

Ingram²,

Brown³

et al. 1988

Exp Physiol

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Young litter‐mate pigs were kept at either 10 or 35 °C and fed either a high (H) or a low (L) food intake producing four groups: 10 H, 10 L, 35 H and 35 L. The numbers of receptors for thyroid hormone in the nuclei of skeletal muscle were estimated and found to be greatest in the 35 H group and least in the 10 L group. The numbers of receptors in the 10 H and 35 L groups were similar and took intermediate values. It is suggested that the differences in receptor numbers represent an adaptation which regulates the tissue response to thyroid hormone. Some possible consequences of this adaptation are discussed.

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Thyroid Activity and Cold Adaptability

Cited by 8 publications

References 83 publications

The effect of ambient temperature upon the secretion of thyroxine in the young pig.

The effect of ambient temperature upon the secretion of thyroxine in the young pig.

The influence of food intake and ambient temperature on the rate of thyroxine utilization.

Thyroid Hormone Nuclear Receptors in Skeletal Muscle as Influenced by Environmental Temperature and Energy Intake

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