Thyroglobulin autoantibodies before radioiodine ablation predict differentiated thyroid cancer outcome

Trimboli, Pierpaolo; Zilioli, Valentina; Imperiali, Mauro; Giovanella, Luca

doi:10.1515/cclm-2017-0033

Cited by 25 publications

(31 citation statements)

References 26 publications

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“…Multivariate logistic analy-sis defined risk stratification as an independent predictor of IL-12A expression. The frequency of P&R of DTC was 12.9%, which was similar to the rate of 11.4% that was reported by Trimboli et al [21]. We showed that IL-12A was related to P&R of thyroid cancer.…”

Section: Discussionsupporting

confidence: 90%

High Expression of Interleukin-12A and Its Association with the Clinicopathology and Prognosis of Differentiated Thyroid Cancer

et al. 2020

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Background: The inflammatory microenvironment is closely related to the occurrence and development of cancer. Members of the interleukin-12 (IL-12) cytokine family play synergistic or antagonistic roles in the tumor microenvironment, in the form of classic heterodimers or newly discovered monomers or homodimers. Objective: The purpose of this study was to investigate the association between IL-12A and the clinicopathology and prognosis of differentiated thyroid cancer (DTC). Methods: A total of 101 pathologically confirmed DTC patients were included in this study. Immunohistochemistry was performed to assess IL-12A expression in DTC and corresponding paracancerous tissues. The associations of IL-12A with clinicopathology and prognosis were evaluated. Results: IL-12A was expressed in both normal thyroid tissues and DTC, but its expression level was significantly higher in DTC than in normal thyroid tissues (p < 0.001). IL-12A was positively correlated with tumor size (p = 0.027), risk stratification (p = 0.020), and TNM (Tumor-Node-Metastasis) stage (p = 0.024), but not with age, sex, patho-logical type, multifocality, extrathyroid extension, lymph node metastasis, and distant metastasis (all p > 0.05). Lymphocytic thyroiditis was found in 26/101 patients (25.7%), which was negatively associated with IL-12A expression (p = 0.018). Multivariate logistic regression analysis showed that risk stratification was the significant independent predictor of IL-12A expression. The rate of disease persistence or recurrence (P&R) was 13/101 (12.9%), and a positive relationship was found between IL-12A expression and P&R (p = 0.020). Disease-free survival was affected by factors such as tumor size, extrathyroid extension, tumor stage (T stage), and IL-12A expression, with p values of 0.006, 0.048, 0.002, and 0.012, respectively. Multivariate Cox proportional-hazards analysis showed that tumor size ≥2 cm (hazard ratio [HR] = 4.041 [95% CI: 1.144-14.274], p = 0.031) and high IL-12A expression (HR = 4.027 [95% CI 1.014-15.994], p = 0.049) were independent predictors of prognosis of DTC patients. Conclusions: IL-12A is highly expressed in DTC and is associated with disease aggressiveness. In addition, IL-12A is an independent predictor of the outcome of DTC.

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Section: Discussionsupporting

confidence: 90%

High Expression of Interleukin-12A and Its Association with the Clinicopathology and Prognosis of Differentiated Thyroid Cancer

et al. 2020

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“…A study by Trimboli et al [ 46 ] evaluated the prognostic impact of pre-RI TgAb levels on long-term outcomes for TgAb-positive DTC patients. Positive TgAb levels before RI increased the risk of disease recurrence over time (OR, 3.57), and disease-free survival was higher in TgAb-negative patients (hazard ratio, 2.59).…”

Section: Postoperative Tgab Follow-upmentioning

confidence: 99%

Clinical implications of anti-thyroglobulin antibody measurement before surgery in thyroid cancer

Lim

2018

Korean J Intern Med

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Thyroglobulin antibody (TgAb) is a class G immunoglobulin and a conventional marker for thyroid autoimmunity. From a clinical perspective, TgAb is less useful than thyroid peroxidase antibodies for predicting thyroid dysfunction. However, TgAb is found more frequently in differentiated thyroid cancer (DTC) and can interfere with thyroglobulin (Tg) measurements, which are used to monitor the recurrence or persistence of DTC. Recent studies suggested a small but consistent role for preoperative TgAb in predicting DTC in thyroid nodules, and in reflecting adverse tumor characteristics or prognosis, including lymph node metastasis, but this is still controversial. Postoperative TgAb can serve as a biomarker for remnant thyroid tissue, so follow-up measures of TgAb are useful for predicting cancer recurrence in DTC patients. Since high serum TgAb levels may also affect the fine needle aspiration washout Tg levels from suspicious lymph nodes of DTC patients, it is important to use caution when interpreting the washout Tg levels in patients who are positive for TgAb.

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“…Kim et al (10) first reported that TgAb could be used as an independent predictor for TC diagnosis (OR=1.80, 95% CI=1.29–2.58), regardless of the presence of AITD, especially in younger patients (11). Furthermore, TC patients with positive TgAb levels had a worse prognosis after surgery (12,13). However, this issue remains controversial.…”

Section: Introductionmentioning

confidence: 99%

Positive thyroid antibodies and risk of thyroid cancer: A systematic review and meta‑analysis

Yang

Zhou

et al. 2019

mol clin onc

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Previous studies assessing the association between thyroid antibodies and the risk of thyroid cancer (TC) have produced inconsistent results. The present study therefore conducted a meta-analysis of the available data. PubMed, Embase and the Cochrane Library were searched for the retrieval of relevant studies and a meta-analysis was conducted to systematically evaluate the association between positive thyroid antibodies and the risk of TC. This search identified 16 articles containing 17 studies on thyroglobulin antibodies (TgAb), which involved a total of 34,488 patients. Positive TgAb was associated with an increased risk of TC [odds ratio (OR)=1.93, 95% confidence interval (CI)=1.64–2.27, I 2 =67.2%]. Whether to adjust for confounding factors (gender and thyroid nodule number) was the main cause of heterogeneity. A stronger association between positive TgAb and an increased risk of TC was identified in the studies with an unadjusted thyroid nodule number (OR=2.14, 95% CI=1.82–2.52), as compared to those with an adjusted thyroid nodule number (OR=1.61, 95% CI=1.29–2.00; P=0.04). In addition, 12 studies on thyroid peroxidase antibodies (TPOAb) involving 30,007 patients were included. Positive TPOAb was associated with an increased risk of TC (OR=1.50, 95%CI=1.16–1.95, I 2 =83.0%). No significant heterogeneity was observed in the PTC group. Positive TgAb is an independent risk factor for TC. The association between positive TPOAb and increased risk of TC needs to be further studied.

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Thyroglobulin autoantibodies before radioiodine ablation predict differentiated thyroid cancer outcome

Abstract: Positive TgAb before RRA indicates higher risk of poor prognosis, but their significant drop 6-12 months later could be considered a favorable factor.

Cited by 25 publications

References 26 publications

High Expression of Interleukin-12A and Its Association with the Clinicopathology and Prognosis of Differentiated Thyroid Cancer

High Expression of Interleukin-12A and Its Association with the Clinicopathology and Prognosis of Differentiated Thyroid Cancer

Clinical implications of anti-thyroglobulin antibody measurement before surgery in thyroid cancer

Positive thyroid antibodies and risk of thyroid cancer: A systematic review and meta‑analysis

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