Thymoquinone reduces hepatic glucose production in diabetic hamsters

Fararh, Khalid; Shimizu, Yasutake; Shiina, Takahiko; Nikami, Hideki; Ghanem, Mohamed M.; Takewaki, Tadashi

doi:10.1016/j.rvsc.2005.01.001

Cited by 82 publications

(59 citation statements)

References 13 publications

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“…Nigella sativa has radical scavenging and anti-inflammatory properties through their thymoquinone and phenolic compounds [35], 2) the partial regeneration and proliferation of β-cells [22], which was confirmed in our study, 3) the hypoglycemic effect of nigella sativa oil which was found to improve insulin insensitivity in diabetic rats [36] and decreased liver gluconeogenesis [37]. In addition nigella sativa was also dose dependently able to reduce glucose absorption from intestine, through inhibition of sodium dependent glucose transport across isolated rat jejunum [38].…”

Section: Discussionsupporting

confidence: 82%

The Antidiabetic Effect of Mesenchymal Stem Cells vs. Nigella sativa Oil on Streptozotocin Induced Type 1 Diabetic Rats

Mohamed¹,

Ali²,

Hosny³

2015

J Cell Sci Ther

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Introduction: Diabetes is a chronic metabolic disorder that has no definitive cure till present. Currently; regenerative medicine using Mesenchymal Stem Cells (MSCs) offers promising treatment. Meanwhile, Nigella Sativa Oil (NSO) shows effectiveness for medication of various illnesses.Objective: This study compares the antidiabetic effect of MSCs vs. NSO on streptozotocin induced type 1 diabetes (T1D) in rat model. Methods:Human cord blood samples were collected. Isolated mononuclear cells were cultured and incubated to isolate MSCs. For experimental animals; after induction of T1D using multiple low dose streptozotocin (MLD-STZ), diabetic rats were divided into 6 groups (n =10); diabetic group 1 and 2 (sacrificed 15 and 30 days post-induction, consequently), NSO treated groups 1 and 2 (received daily NSO I.P. injection, sacrificed 15 and 30 days postinduction, consequently), MSCs treated groups 1 and 2 (72 hours post-induction, animals were treated with twice intravenous injection of 1×106 cells/rat, 24 hours apart, without immunosuppression, sacrificed 15 and 30 days of induction, consequently).Results: Low blood glucose levels were detected in both MSCs and NSO groups, which reached near normal levels within 15 days. This was accompanied by improvement of the histopathological changes and increase in the immunreactive insulin secreting cells, obviously detected after 30 days.

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Section: Discussionsupporting

confidence: 82%

The Antidiabetic Effect of Mesenchymal Stem Cells vs. Nigella sativa Oil on Streptozotocin Induced Type 1 Diabetic Rats

Mohamed¹,

Ali²,

Hosny³

2015

J Cell Sci Ther

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“…Thirty days after TQ treatment, hepatocytes were isolated to determine liver glucose production. Glucose production after 2 h incubation of the isolated hepatocytes with gluconeogenic precursors (alanine, glycerol and lactate) was significantly lower in hamsters treated with TQ [50]. These results demonstrate that the antidiabetic action of TQ is at least partially mediated through a decrease in hepatic gluconeogenesis.…”

Section: Antidiabetic Activity In Stz Induced Diabetic Hamstersmentioning

confidence: 60%

Antidiabetic Properties of a Spice Plant Nigella sativa

Mathur

2011

J Endocrinol Metab

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Seeds of Nigella sativa (black cumin/kalonji) used in pickles as spice, have also been traditionally used in treatment of many diseases including diabetes and hypertension. Among many activities exhibited by N. sativa and its constituents in animal experiments, antidiabetic property is most important. Thymoquinone (TQ), a volatile oil, is one of its active constituents but antidiabetic activity has also been shown by its aqueous extract and defatted extract. N. sativa may be beneficial in diabetic individuals and those with glucose intolerance as it reduces appetite, glucose absorption in intestine, hepatic gluconeogenesis, blood glucose level, cholesterol, triglycerides, body weight and simulates glucose induced secretion of insulin from beta-cells in pancreas; improves glucose tolerance as efficiently as metformin; yet it has not shown significant adverse effects and has very low toxicity. In streptozotocin (STZ) induced diabetic rats it causes gradual partial regeneration of pancreatic beta-cells, increases the lowered serum insulin concentrations and decreases the elevated serum glucose. N. sativa has antioxidant activity and protective role of TQ against development of type I diabetes may be via NO inhibitory pathway. It also exerts an insulin-sensitizing action in hepatocytes. Seeds of N. sativa have been safely consumed by human patients in many clinical trials which however were not aimed to assess its antidiabetic activity. In future clinical studies may show potential of N. sativa, its constituents or their synthetic analogues, in prevention and control of diabetes.

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“…TQ (2-isopropyl-5-methyl-1,4-benzoquinone), the main active component of the essential oil of Nigella sativa seeds, has various pharmacological effects. It has been reported to display various pharmacological activities such as antioxidant (7), antidiabetic (8), cardioprotective (9), hepatoprotective (10), neuroprotective (11), nephroprotective (12), anti-infl ammatory (13), anti-mutagenic (14), and anticancer (15) effects. TQ is of low toxicity (LD50 2.4 g/kg) and is well tolerated when given subchronically till 90 mg/ kg/day for 90 days (16).…”

Section: Introductionmentioning

confidence: 99%

The protective effect of thymoquinone over olanzapine-induced side effects in liver, and metabolic side effects

Bilğiç¹,

Korkmaz²,

Azırak³

et al. 2018

BLL

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OBJECTIVES: The aim of the study was to investigate the possible protective qualities of thymoquinone (TQ) against the side-effects of olanzapine (OLZ) in an experimental model in rat liver with histologic and biochemical assessments. METHODS: Experimental procedures were performed on 35 female Sprague Dawley rats. Rats were randomly divided into fi ve groups as: group 1: control; group 2: OLZ; group 3: OLZ+TQ-1; group 4: OLZ+TQ-2; and group 5: OLZ+TQ-3. RESULTS: The results showed that a 2-week administration of OLZ (4 mg/kg, once a day for the fi rst week, 8 mg/kg once a day for the second week, p.o.) and treatment with TQ (25, 50, 100 mg/kg, once daily, p.o.) signifi cantly reduced weight gain induced by OLZ. In addition, TQ increased the total antioxidant status (TAS), high-density lipoprotein cholesterol (HDL), insulin levels and decreased serum oxidative stress index (OSI), total oxidant status (TOS), alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transpeptidase (GGT), low density lipoprotein cholesterol (LDL), glucose, triglycerides (TG) and total cholesterol (CH) levels signifi cantly (p < 0.05). CONCLUSION: This study revealed that treatment with TQ might protect liver tissue against the side-effects of OLZ. TQ could be an effective course of therapy to enhance therapeutic effi cacy (Tab. 4, Fig. 4, Ref. 47). Text in PDF www.elis.sk.

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Thymoquinone reduces hepatic glucose production in diabetic hamsters

Cited by 82 publications

References 13 publications

The Antidiabetic Effect of Mesenchymal Stem Cells vs. Nigella sativa Oil on Streptozotocin Induced Type 1 Diabetic Rats

The Antidiabetic Effect of Mesenchymal Stem Cells vs. Nigella sativa Oil on Streptozotocin Induced Type 1 Diabetic Rats

Antidiabetic Properties of a Spice Plant Nigella sativa

The protective effect of thymoquinone over olanzapine-induced side effects in liver, and metabolic side effects

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