Thymoquinone a Potential Therapeutic Molecule from the Plant Nigella sativa: Role of Colloidal Carriers in its Effective Delivery

Negi, Poonam; Rathore, Charul; Sharma, Gajanand; Singh, Bhupinder; Katare, O. P.

doi:10.2174/1872211311666171129121128

Cited by 28 publications

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“…Thymoquinone (TQ, 2‐methyl‐5‐isopropyl‐1,4‐benzoquinone), a bioactive component extracted from the seeds of Nigella sativa , has been proved to exert wide‐ranging pharmacological activities, with anti‐tumor, anti‐inflammatory, anti‐oxidant, anti‐microbial, anti‐convulsant and anti‐diabetic properties . Therefore, TQ has been regarded as a promising agent for numerous diseases.…”

Section: Introductionmentioning

confidence: 99%

“…has been proved to exert wide-ranging pharmacological activities, with anti-tumor, anti-inflammatory, anti-oxidant, anti-microbial, anti-convulsant and anti-diabetic properties. [6][7][8][9] Therefore, TQ has been regarded as a promising agent for numerous diseases. Previous studies have revealed that TQ may exhibit high anti-tumor efficiency against various cancers, such as breast cancer, gastric cancer, cervical cancer, colon cancer, central nervous system cancer, ovarian cancer, prostate cancer, bladder cancer and renal cell cancer.…”

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confidence: 99%

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Thymoquinone inhibits the metastasis of renal cell cancer cells by inducing autophagy via AMPK/mTOR signaling pathway

et al. 2018

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Thymoquinone (TQ, 2‐methyl‐5‐isopropyl‐1,4‐benzoquinone), a bioactive constituent extracted from the seeds of Nigella sativa, has been proved to exert anti‐tumor efficiency in various cancers. Autophagy is a self‐digestion phenomenon, and its role in tumor formation and progression remains controversial. In the present study, we investigated the effects of TQ on renal cell cancer (RCC) cell lines (786‐O and ACHN) using wound healing assay, transwell assay and western blot analysis. We found that TQ effectively inhibited the metastatic capacity of RCC cells in vitro, which was also verified in a xenograft model. Meanwhile, we observed LC3 puncta and detected the expression of LC3 in TQ‐treated RCC cells, and then found that autophagy was induced by TQ in 786‐O and ACHN cell lines. In addition, TQ inhibited the migration and invasion as well as the EMT in RCC cells in an autophagy‐dependent manner. To further explore the underlying mechanism, we detected the AMPK/mTOR signaling pathway. The results indicated that TQ inhibited the metastasis of RCC cells by inducing autophagy via AMPK/mTOR signaling pathway. In conclusion, our findings provide a novel therapeutic strategy that aims at TQ‐induced autophagy in RCC treatment.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Thymoquinone inhibits the metastasis of renal cell cancer cells by inducing autophagy via AMPK/mTOR signaling pathway

et al. 2018

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“…Prevention of the side effects of cisplatin is one of the major issues in treating cancer patients [9,10] and so various methods have been tested to prevent these side effects of cisplatin, such as combined use of free radical scavengers [6,7]. Therefore, the present study was designed to elucidate the availability of using some types of antioxidants of natural sources to alleviate these side effects upon cisplatin treatment [9,10]. In this study, TQ and Vit E were used either separately or in their combination form to declare their role in ameliorating the adverse effects of cisplatin induced nephropathy and hepatotoxicity.…”

Section: Discussionmentioning

confidence: 99%

“…Thymoquinone (the main constituent of Nigella sativa seed volatile oil) possesses strong antioxidant properties that protect against oxidative damage resulting from free radical-generating agents [8]. It was reported to have anti-inflammatory actions, an analgesic and a protective effect against chemical induced carcinogenesis [9,10]. Thymoquinone also have a protective effect against diabetic nephropathy [11].…”

Section: Introductionmentioning

confidence: 99%

Potential synergistic antioxidant effect of thymoquinone and vitamin E on cisplatin-induced acute nephropathy in rats

Alghamdi

Al‐Seeni

Ghoneim

2020

Clinical Nutrition Experimental

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“…TQ sebagai antioksidant dapat meningkatkan sekresi insulin dengan meningkatkan metabolisme energi di mitokondria dan meningkatkan jalur intraseluler pada reseptor insulin. Efek hipoglikemik pada TQ tidak hanya berkaitan dengan kerja insulin, tetapi juga kemampuan TQ untuk menurunkan glukoneogenesis dengan menekan sintesis enzim glukoneogenik (Negi, Rathore, Sharma, Singh, & Katare, 2018).…”

Section: Worldunclassified

Pemberian Ekstrak Biji Jintan Hitam pada Diabetes Melitus Tipe 2 sebagai Terapi

Pandiangan

Ginting²

2019

farmasetis

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Diabetes melitus atau DM merupakan kelompok penyakit metabolic dengan karakteristik hiperglikemia yang terjadi akibat kelainan sekresi insulin, kelainan kerja insulin atau kedua-duanya. Prevalensi diabetes melitus pada penduduk usia>15 tahun sebesar 6,9%, Toleransi Glukosa Terganggu atau TGT sebesar 29,9% dan Gula Darah Puasa Terganggu atau GDPT sebesar 36,6%. Diabetes mellitus merupakan silent killer. Adapun gejala-gejala klasik pada diabetes adalah polifagi, polidipsi dan poliuri. Penanganan pasien diabetes terbagi atas terapi farmakologi dan non farmakologi. Literatur review ini bertujuan mengetahui efek pemberian ekstrak biji jintan hitam terhadap pasien diabetes mellitus tipe 2 sebagai terapi alternatif yang sudah dilakukan oleh peneliti sebelumnya. Metode yang digunakan dalam artikel ini adalah penelusuran artikel melalui database NCBI dan Google Scholar. Tahun penerbitan sumber pustaka adalah dari tahun 2001 sampai 2019 dengan 32 sumber pustaka. Berbagai penelitian eksperimental yang dilakukan menunjukkan bahwa kandungan bioaktif pada biji jintan hitam bermanfaat sebagai anti diabetes. Kandungan biji jintan hitam sebagai antioksidan dapat meningkatkan sekresi insulin dengan meningkatkan metabolism energi di mitokondria, meningkatkan jalur intraseluler pada reseptor dan menurunkan glukoneogenesis dengan menekan sintesis enzim glukoneogenik. Kata kunci: diabetes melitus, thymoquine, anti diabetes EFFECT OF BLACK SEED EXTRACT FOR DIABETES MELLITUS TYPE 2 AS ALTERNATIVE THERAPY ABSTRACT Diabetes mellitus or DM is an group metabolic disease with the hyperglycemia characteristic because of insulin secretion disorder, insulin activity or both of them. The prevalence of diabetes mellitus at the age > 15 years old, is 6.9 percent, 29.9 percent ImpairedGlucoseTolerance or IGT and 36.6 percent ImpairedFastingGlycaemia or IFG.. Diabetes mellitus is a silent killer. As for classic symptoms of diabetes are polyphagia, polydipsia and polyuria. Intervention for patient diabetes divided by pharmacological and non pharmacological intervention. This literature review aims to find out which effect of Black Seed for patient of diabetes mellitus type 2 as alternative therapythat have been done by previous researchers. The method used in this article is the search of articles through the NCBI and Google Scholar databases. The year of publication of library sources is from 2009 to 2018 with 29 library sources.Various experimental research conducted showed part bioactive component useful as antidiabetic. Bioactive component as antioxidant can increase insulin secretion by increasing energy metabolism at mitochondria and increasing intraceluler pathway on insulin receptor and reduce gluconeogenesis by reduce synthesis gluconeogenic enzyme. Keywords: diabetes mellitus, thymoquinone, anti diabetic

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Thymoquinone a Potential Therapeutic Molecule from the Plant Nigella sativa: Role of Colloidal Carriers in its Effective Delivery

Cited by 28 publications

References 0 publications

Thymoquinone inhibits the metastasis of renal cell cancer cells by inducing autophagy via AMPK/mTOR signaling pathway

Thymoquinone inhibits the metastasis of renal cell cancer cells by inducing autophagy via AMPK/mTOR signaling pathway

Potential synergistic antioxidant effect of thymoquinone and vitamin E on cisplatin-induced acute nephropathy in rats

Pemberian Ekstrak Biji Jintan Hitam pada Diabetes Melitus Tipe 2 sebagai Terapi

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