2013
DOI: 10.1038/nm.3281
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Thymic stromal lymphopoietin–elicited basophil responses promote eosinophilic esophagitis

Abstract: Eosinophilic esophagitis (EoE) is a food allergy-associated inflammatory disease characterized by esophageal eosinophilia. EoE has become increasingly common, but current management strategies are nonspecific. Thus, there is an urgent need to identify specific immunological pathways that could be targeted to treat this disease. EoE is associated with polymorphisms in the gene that encodes thymic stromal lymphopoietin (TSLP), a cytokine that promotes allergic inflammation, but how TSLP might contribute to EoE d… Show more

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Cited by 353 publications
(410 citation statements)
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References 62 publications
(79 reference statements)
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“…In sharp contrast to our expectations, prurigo-like skin lesions in mice were exacerbated in the absence of STAT6 signaling. In parallel with these findings, histopathologically, basophil infiltration was enhanced, which might be associated with increased IL-33 and TSLP expression (46,51) (36). Eosinophil infiltration in the dermis is a characteristic feature of human prurigo reactions, but the pathogenic role of eosinophils in allergic inflammation is still a matter of disagreement.…”
Section: Discussionmentioning
confidence: 66%
“…In sharp contrast to our expectations, prurigo-like skin lesions in mice were exacerbated in the absence of STAT6 signaling. In parallel with these findings, histopathologically, basophil infiltration was enhanced, which might be associated with increased IL-33 and TSLP expression (46,51) (36). Eosinophil infiltration in the dermis is a characteristic feature of human prurigo reactions, but the pathogenic role of eosinophils in allergic inflammation is still a matter of disagreement.…”
Section: Discussionmentioning
confidence: 66%
“…The TSLP association with eosinophilic esophagitis 53 is another condition highly dependent on T H 2 cells and cytokines. 55,56 Inhibition of TSLP activity by intravenous injection of a human anti-TSLP antibody for up to 3 months attenuated both early and late bronchial reactions to exposure to allergen challenge, supporting the role of this protein in allergic asthma and highlighting its potential as a therapeutic target. 57 The MHC locus has been associated with asthma and asthma-related phenotypes in many studies, and its role in the development and activation of T cells makes HLA alleles key regulators of immunopathology.…”
Section: Functions Of Genes Revealed By Gwa Studiesmentioning
confidence: 93%
“…Une publication récente, qui rassemble certains des plus grands experts de l'EoE des deux côtésd e l'Atlantique, présente désormais l'EoE comme une hypersensibilité alimentaire non-dépendante des IgE, en soulignant son origine immuno-antigénique mais en la distinguant des allergies alimentaires [9]. [29,30,31]. Ces molécules sont aussi connues comme étant directement impliquées dans la différentiation et/ou le recrutement des éosinophiles.…”
Section: Etiologie Et Pathogénieunclassified
“…On aa ussi montré que l'IL-13 avait des activitésd irectes sur les cellules épithéliales de l'oesophage qui pourraient expliquer certaines lésions et symptômes de l'EoE [32]. Et donc ces molécules ont été sélectionnées comme les premiers candidats potentiels pour développer de nouvelles thérapies de l'EoE, notamment à partir de modèles animaux prometteurs [33,34,31,35]. En revanche, il n'a pas encore été démontré que des anticorps anti-IL-5 ou anti-IL-13 utilisésc hez des patients souffrant d'EoE pouvaient entraîner un bénéfice clinique, malgré quelques signes positifs dans des études préliminaires [36,37], alors même que l'anti-IL-5 utilisé (mepolizumab) ar e ç uu na grément aux USAp our traiter l'asthme sévère.…”
Section: Etiologie Et Pathogénieunclassified
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