Thymic epithelial tumors: Comparison of CT and MR imaging findings of low-risk thymomas, high-risk thymomas, and thymic carcinomas

Sadohara, Junko; Fujimoto, Kiminori; Müller, Néstor L.; Kato, Seiya; Takamori, Shinzo; Ohkuma, Kazuaki; Tazaki, Hiroshi; Hayabuchi, Naofumi

doi:10.1016/j.ejrad.2006.05.003

Cited by 191 publications

(226 citation statements)

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“…In this study, tumor size, tumor shape, necrosis or cystic change, capsule integrity, invasion of the adjacent tissue, lymphadenopathy and the presence of pleural effusion were significantly different between the different pathological types of thymic tumors. The malignant characteristics of type B2 and B3 thymomas and thymic carcinomas were obvious, consistent with previous reports (Tomiyama et al, 2002;Han et al, 2003;Sadohara et al, 2006).…”

Section: Discussionsupporting

confidence: 80%

“…The youngest patient in this study was 18 years old. There was no significant difference in age or gender between the different pathological classification groups, consistent with reports in the literature (Sadohara et al, 2006). CT data is an important basis for the selection of treatment for thymic tumors.…”

Section: Discussionsupporting

confidence: 78%

“…Tumor invasiveness increases gradually. CT signs reflect tumor characteristics well (Sadohara et al, 2006;Priola et al, 2010). In this study, tumor size, tumor shape, necrosis or cystic change, capsule integrity, invasion of the adjacent tissue, lymphadenopathy and the presence of pleural effusion were significantly different between the different pathological types of thymic tumors.…”

Section: Discussionmentioning

confidence: 75%

“…In this study, 91% and 74% of type A and type AB thymomas, respectively, were round or oval, while 46%, 75%, and 85% of type B2 thymomas, type B3 thymomas, and thymic carcinomas, respectively, were irregularly shaped, supporting the aforementioned point of view. Sadohara et al (2006) reported that necrosis or cystic change occurred in 67% of thymic carcinomas. In this study, necrosis or cystic change occurred in 67% and 57% of type B3 thymomas and thymic carcinomas, respectively, consistent with the previous study.…”

Section: Discussionmentioning

confidence: 99%

“…Studies have suggested that this WHO classification reflects well the clinical and prognostic features of thymic tumors (Chen et al, 2002;Okumura et al, 2002;Kondo et al, 2004). There have been reports about the CT manifestations of thymic tumors with different WHO pathological classifications, but the number of cases in these reports was limited (Tomiyama et al, 2002;Han et al, 2003;Sadohara et al, 2006). To explore further the relationship between the CT manifestations and the WHO pathological classification, we conducted a retrospective analysis of 105 cases of thymic tumors.…”

Section: Introductionmentioning

confidence: 99%

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Relationship Between Computed Tomography Manifestations of Thymic Epithelial Tumors and the WHO Pathological Classification

Liu

Qu²,

Liao³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Objective: To explore the relationship between computed tomography (CT) manifestations of thymoma and its WHO pathological classification. Methods: One hundred and five histopathologically confirmed cases were collected for their pathological and CT characteristics and results were statistically compared between different pathological types of thymoma. Results: Tumor size, shape, necrosis or cystic change, capsule integrity, invasion to the adjacent tissue, lymphadenopathy, and the presence of pleural effusion were significantly different between different pathological types of thymomas (P <0.05). Type B2, B3 tumors and thymic carcinomas were greater in size than other types. More than 50% of type B3 tumors and thymic carcinomas had a tumor size greater than 10 cm. The shape of types A, AB, and B1 tumors were mostly round or oval, whereas 75% of type B3 tumors and 85% of thymic carcinomas were irregular in shape. Necrosis or cystic change occurred in 67% of type B3 thymomas and 57% of thymic carcinomas, respectively. The respective figures for capsule destruction were 83% and 100% . Increases in the degree of malignancy were associated with increases in the incidence of surrounding tissue invasion: 33%, 75%, and 81% in type B2, type B3, and thymic carcinomas, respectively. Pleural effusion occurred in 48% of thymic carcinomas, while calcification was observed mostly in type B thymomas. Conclusions: Different pathological types of thymic epithelial tumors have different CT manifestations. Distinctive CT features of thymomas may reflect their pathological types.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%