Positron Emission Tomography–Computed Tomography in Paraneoplastic Neurologic Disorders

Abstract

To evaluate the cancer detection rate of wholebody positron emission tomography-computed tomography (PET-CT) in a paraneoplastic neurologic context.

18F-FDG PET-CT in the evaluation of paraneoplastic syndromes

“…These are similar to figures reported in the literature previously [11]. Our test characteristics for PET-CT showed specificity (82%), NPV (100%) and false-positive rates (42%) comparable to those in the literature [9,11]. Our sensitivity was higher than that reported by some authors but was in keeping with the results of Linke et al [15].…”

“…This is higher than the results of some previous studies from the USA and Europe [9,11] but is concordant with the results of another large reported series from the UK [3].…”

18F-FDG PET-CT in the evaluation of paraneoplastic syndromes

“…These are similar to figures reported in the literature previously [11]. Our test characteristics for PET-CT showed specificity (82%), NPV (100%) and false-positive rates (42%) comparable to those in the literature [9,11]. Our sensitivity was higher than that reported by some authors but was in keeping with the results of Linke et al [15].…”

“…This is higher than the results of some previous studies from the USA and Europe [9,11] but is concordant with the results of another large reported series from the UK [3].…”

Utility of 18F-FDG-PET/CT in patients suspected of paraneoplastic neurological syndrome: importance of risk classification

“…Our test characteristics for PET/CT showed sensitivity (64 %), specificity (71 %), negative predictive and positive predictive values (92 and 28 %) comparable to those in the literature [17,18].…”

CSF complements serum for evaluating paraneoplastic antibodies and NMO-IgG

“…Seronegativity for paraneoplastic antibodies does not exclude a diagnosis of cancer, and testing for occult malignancy should proceed in highly suspicious cases. 5 The low positivity rates for most paraneoplastic antibodies in this study are consistent with their rarity, and reflects the ordering of this testing in patients with diverse neurologic presentations, where no cause has been established. 1 The more frequent detection of NMO-IgG and NMDA receptor antibody is consistent with the more narrow clinical contexts for ordering these 2 tests.…”

18F-FDG PET-CT in the evaluation of paraneoplastic syndromes

“…These are similar to figures reported in the literature previously [11]. Our test characteristics for PET-CT showed specificity (82%), NPV (100%) and false-positive rates (42%) comparable to those in the literature [9,11]. Our sensitivity was higher than that reported by some authors but was in keeping with the results of Linke et al [15].…”

“…This is higher than the results of some previous studies from the USA and Europe [9,11] but is concordant with the results of another large reported series from the UK [3].…”

Utility of 18F-FDG-PET/CT in patients suspected of paraneoplastic neurological syndrome: importance of risk classification

“…Our test characteristics for PET/CT showed sensitivity (64 %), specificity (71 %), negative predictive and positive predictive values (92 and 28 %) comparable to those in the literature [17,18].…”

CSF complements serum for evaluating paraneoplastic antibodies and NMO-IgG

“…Seronegativity for paraneoplastic antibodies does not exclude a diagnosis of cancer, and testing for occult malignancy should proceed in highly suspicious cases. 5 The low positivity rates for most paraneoplastic antibodies in this study are consistent with their rarity, and reflects the ordering of this testing in patients with diverse neurologic presentations, where no cause has been established. 1 The more frequent detection of NMO-IgG and NMDA receptor antibody is consistent with the more narrow clinical contexts for ordering these 2 tests.…”

18F-FDG PET-CT in the evaluation of paraneoplastic syndromes

“…These are similar to figures reported in the literature previously [11]. Our test characteristics for PET-CT showed specificity (82%), NPV (100%) and false-positive rates (42%) comparable to those in the literature [9,11]. Our sensitivity was higher than that reported by some authors but was in keeping with the results of Linke et al [15].…”

“…This is higher than the results of some previous studies from the USA and Europe [9,11] but is concordant with the results of another large reported series from the UK [3].…”

Utility of 18F-FDG-PET/CT in patients suspected of paraneoplastic neurological syndrome: importance of risk classification

“…Our test characteristics for PET/CT showed sensitivity (64 %), specificity (71 %), negative predictive and positive predictive values (92 and 28 %) comparable to those in the literature [17,18].…”

CSF complements serum for evaluating paraneoplastic antibodies and NMO-IgG

“…Seronegativity for paraneoplastic antibodies does not exclude a diagnosis of cancer, and testing for occult malignancy should proceed in highly suspicious cases. 5 The low positivity rates for most paraneoplastic antibodies in this study are consistent with their rarity, and reflects the ordering of this testing in patients with diverse neurologic presentations, where no cause has been established. 1 The more frequent detection of NMO-IgG and NMDA receptor antibody is consistent with the more narrow clinical contexts for ordering these 2 tests.…”