Paraneoplastic Syndromes: An Approach to Diagnosis and Treatment

Pelosof, Lorraine; Gerber, David E.

doi:10.4065/mcp.2010.0099

Cited by 569 publications

(584 citation statements)

References 157 publications

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“…The suspicion of these manifestations -which depends on the type of tumor and may preceed the diagnosis of cancer -enables the diagnosis of the oncological pathology even in earlier stages. The successful treatment of the underlying disease leads to the improvement of the PNS (2).…”

Section: Introductionmentioning

confidence: 99%

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The coexistence of hypercalcemia and hypoglycemia in a patient with a renal tumor and B cell lymphoma

Soutelo¹,

Moldes²,

Frisone³

et al. 2017

Arch. Endocrinol. Metab.

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SUMMARYParaneoplastic syndromes are a heterogeneous group of malignant diseases caused by events which involve endocrine, immune and metabolic aspects and whose symptoms vary according to the substance produced and the primary tumor. Hypercalcemia is a frequent complication in cancer patients. Prognosis of cancer patients with hypercalcemia is usually poor. A factor called parathyroid hormone related peptide, whose actions are similar to those of the parathyroid hormone, is thought to be the most common cause of malignancy associated hypercalcemia. Non-islet hypoglycemic cell tumor consists of a rare syndrome characterized by the presence of a solid tumor and severe fasting hypoglycemia determined by an insulin-independent pathway. We report a case of a 59-year-oldman with a renal tumor and a T-cell rich large B cell lymphoma who was hospitalized due to severe hypercalcemia and hypoglycemia. The laboratory examination reported hypercalcemia with inhibited PTH and hypoglycemia with inhibited insulin secretion, arriving to the conclusion of tumoral peptide production. He received denosumab and corticoid therapy. The patient died one month later despite initial improvement after medical treatment. While a single paraneoplastic manifestation may be expected in most tumors, the coexistence of two or more of them is rare, except in hepatocellular carcinomas, and it has not yet been described in renal tumors. Arch Endocrinol Metab. 2017;61(1):98-102

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Section: Introductionmentioning

confidence: 99%

“…The most common endocrine manifestations are the inappropriate antidiuretic hormone secretion, Cushing's syndrome, hypercalcemia and hypoglycemia as well as hypocalcemia, osteomalacia, hypercholesterolemia and hyperuricemia (2).…”

Section: Introductionmentioning

confidence: 99%

The coexistence of hypercalcemia and hypoglycemia in a patient with a renal tumor and B cell lymphoma

Soutelo¹,

Moldes²,

Frisone³

et al. 2017

Arch. Endocrinol. Metab.

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“…The patient died after a total of 11 months disease. Discussion PNS is relatively rare and occurs in up to 8% of all cancer patients [2] . It is known that some rheumatological diseases are associated with increased incidence of cancer.…”

Section: Case Reportmentioning

confidence: 99%

“…Paraneoplastic rheumatic syndromes (PRS) are rheumatologic diseases that are triggered by a malignant disease. Symptoms of PRS can not be explained by the anatomical location of the tumor or metastases, and they often remit following treatment of the underlying disease [2] .…”

Section: Introductionmentioning

confidence: 99%

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Severe Joint Pain as a Manifestation of Paraneoplastic Rheumatic Syndrome in a Patient with a Malignant Lymphoma: A Case Report and Review of the Literature

2015

Itch Pain

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A Common Purpuric Rash With Uncommon Association in a Woman With Pedal Edema

Akhtar

Mangla

2019

JAMA Oncol

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A 70-year-old Indian woman presented with a generalized rash over the lower extremity associated with pedal edema extending up to the shins. The onset was gradual and started on the lower extremities and gradually extended to involve the lower trunk. The rash was associated with mild discomfort. The patient denied itching, weeping, or bleeding from the rash. She denied any constitutional symptoms (weight loss, fever, night sweats), joint pains, history of blood in urine, periorbital edema, and recent intake of medications or herbal medications. Social history was significant for 25 pack-years of smoking. Physical examination revealed multiple well-defined, coalescent, erythematous, palpable, purpuralike lesions that were predominantly present over the trunk and lower extremities (Figure , A and B). Laboratory test results at presentation included a hemoglobin level of 11.2 g/dL (to convert to g/L, multiply by 10), mean corpuscular volume of 84 fL, erythrocyte sedimentation rate of 72 mm/h, and a lactate dehydrogenase level of 412 IU/L. Hepatic and renal function levels were within normal limits. Complement levels were normal. Hepatitis B and C and HIV profiles were negative. A chest radiograph showed a 2-cm lesion in the upper lobe of the left lung. A computed tomographic scan of the chest showed a spiculated mass in the same region along with mediastinal lymphadenopathy. An ultrasound of the abdomen showed bilateral adrenal masses. A lesional skin biopsy specimen was obtained (Figure , C).

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Paraneoplastic Syndromes: An Approach to Diagnosis and Treatment

Cited by 569 publications

References 157 publications

The coexistence of hypercalcemia and hypoglycemia in a patient with a renal tumor and B cell lymphoma

The coexistence of hypercalcemia and hypoglycemia in a patient with a renal tumor and B cell lymphoma

Severe Joint Pain as a Manifestation of Paraneoplastic Rheumatic Syndrome in a Patient with a Malignant Lymphoma: A Case Report and Review of the Literature

A Common Purpuric Rash With Uncommon Association in a Woman With Pedal Edema

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