Thymectomy for Tumor and Myasthenia Gravis

Fifty‐four patients with thymoma were seen at Memorial Hospital from 1928 to 1972. There were 18 benign and 36 malignant thymomas. Benign tumors were completely encapsulated. Malignant tumors were non‐encapsulated or incompletely encapsulated and invasive. All patients with benign thymoma were treated by resection alone. None had recurrent disease or died with tumor for periods ranging from 5 to 17 years after resection. Patients with malignant thymoma treated by resection alone had recurrent tumor within 5 years and subsequently died of their disease. All malignant thymoma patients who were alive free of disease for 5 or more years had radiation therapy and resection. Clinicopathologic features indicating a poor prognosis were: a non‐encapsulated tumor of a predominantly epithelial cell type, superior vena caval syndrome, malignant pleural effusion, supraclavicular lymph node involvement, dysphagia, hoarseness, myasthenia gravis, erythroid hypoplasia, and hypogammaglobulinemia.

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Thymomas: Clinicopathologic features, therapy, and prognosis

Batata

Martini

Huvos

et al. 1974

Cancer

211

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The role of radiotherapy in the management of malignant thymoma

Penn

Hope-Stone

1972

Journal of British Surgery

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SUMMARYA series of 18 cases of malignant thymoma referred for radiotherapy during a 21-year period is reviewed. The presentation, treatment policy, and results are examined. Of the 7 cases treated with a full radical dose all were alive at 3 years, all 4 cases followed for 5 years survived that period, and 3 of the 4 cases followed for 10 years were alive at that time. Of these, only 3 cases had had macroscopically complete excision of the tumour at thoracotomy. These findings suggest that postoperative radiotherapy should be of benefit in all cases of invasive thymoma whether operable or otherwise.

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Surgical Management of Myasthenia Gravis

Wolfe¹,

Sealy²,

Young³

1972

The Annals of Thoracic Surgery

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Thymectomy for Tumor and Myasthenia Gravis

Cited by 5 publications

References 10 publications

Thymomas: Clinicopathologic features, therapy, and prognosis

Thymomas: Clinicopathologic features, therapy, and prognosis

The role of radiotherapy in the management of malignant thymoma

Surgical Management of Myasthenia Gravis

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